Search results for " Mismatch"

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

2011

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these agents induce a plethora of different DNA lesions, it is firstly important to identify the specific lesions responsible for initiating apoptosis before the apoptotic executing pathways can be elucidated. Here, we describe specific DNA lesions that have been identified as apoptosis triggers, their repair and the signaling provoked by them. We discuss methylating agents such as temozolomide, ionizing radiation and cisplatin, all of them are important in cancer therapy. We show that the potentially lethal events for the cell are O(6)-methylguanine adducts that are converted by mismatch repair into DNA dou…

DNA repair systems

2006

Detergent Properties Influence the Stability of the Glycophorin A Transmembrane Helix Dimer in Lysophosphatidylcholine Micelles

2012

AbstractDetergents might affect membrane protein structures by promoting intramolecular interactions that are different from those found in native membrane bilayers, and fine-tuning detergent properties can be crucial for obtaining structural information of intact and functional transmembrane proteins. To systematically investigate the influence of the detergent concentration and acyl-chain length on the stability of a transmembrane protein structure, the stability of the human glycophorin A transmembrane helix dimer has been analyzed in lyso-phosphatidylcholine micelles of different acyl-chain length. While our results indicate that the transmembrane protein is destabilized in detergents w…

From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring a…

2007

After Golgi-Cajal mapped neural circuits, the discovery and mapping of the central monoamine neurons opened up for a new understanding of interneuronal communication by indicating that another form of communication exists. For instance, it was found that dopamine may be released as a prolactin inhibitory factor from the median eminence, indicating an alternative mode of dopamine communication in the brain. Subsequently, the analysis of the locus coeruleus noradrenaline neurons demonstrated a novel type of lower brainstem neuron that monosynaptically and globally innervated the entire CNS. Furthermore, the ascending raphe serotonin neuron systems were found to globally innervate the forebrai…

Design, assembly and characterization of silicide-based thermoelectric modules

2016

ID: 1143 In: Energy conversion and management, 13-21. Summary: Highlights•Novel silicide-based thermoelectric modules were experimentally investigated.•The modules produced high power of 1.04 W at 405 °C and 3.24 W at 735 °C.•An estimated module efficiency of 5.3% represent the highest reported for silicide systems.AbstractSilicides have attracted considerable attention for use in thermoelectric generators due mainly to low cost, low toxicity and light weight, in contrast to conventional materials such as bismuth and lead telluride. Most reported work has focused on optimizing the materials properties while little has been done on module testing. In this work we have designed and tested mod…

Optimization of photovoltaic energy production through an efficient switching matrix

2013

This work presents a preliminary study on the implementation of a new system for power output maximization of photovoltaic generators under non-homogeneous conditions. The study evaluates the performance of an efficient switching matrix and the relevant automatic reconfiguration control algorithms. The switching matrix is installed between the PV generator and the inverter, allowing a large number of possible module configurations. PV generator, switching matrix and the intelligent controller have been simulated in Simulink. The proposed reconfiguration system improved the energy extracted by the PV generator under non-uniform solar irradiation conditions. Short calculation times of the pro…

A mathematical model to determine the electrical energy production in photovoltaic fields under mismatch effect

2009

Among the electrical energy production systems from renewable sources, the photovoltaic one represents today one of the most efficient and technically tested choice. In this paper the authors present a mathematical model that allows the maximization of the generated power of photovoltaic (PV) plants under unequally radiation conditions. In particular, thanks to the model of a PV plant, unequally radiated, developed in Matlab-Simulink environment, in this paper the mismatch problem of PV plants is dealt with. The simulations curried out allow to assert that by putting into action re-configuration techniques of series-parallel connections of PV plants, under unequally radiation, can allow to …

Isometric Words Based on Swap and Mismatch Distance

2023

An edit distance is a metric between words that quantifies how two words differ by counting the number of edit operations needed to transform one word into the other one. A word f is said isometric with respect to an edit distance if, for any pair of f-free words u and v, there exists a transformation of minimal length from u to v via the related edit operations such that all the intermediate words are also f-free. The adjective 'isometric' comes from the fact that, if the Hamming distance is considered (i.e., only mismatches), then isometric words are connected with definitions of isometric subgraphs of hypercubes. We consider the case of edit distance with swap and mismatch. We compare it…

From Nerode's congruence to Suffix Automata with mismatches

2009

AbstractIn this paper we focus on the minimal deterministic finite automaton Sk that recognizes the set of suffixes of a word w up to k errors. As first result we give a characterization of the Nerode’s right-invariant congruence that is associated with Sk. This result generalizes the classical characterization described in [A. Blumer, J. Blumer, D. Haussler, A. Ehrenfeucht, M. Chen, J. Seiferas, The smallest automaton recognizing the subwords of a text, Theoretical Computer Science, 40, 1985, 31–55]. As second result we present an algorithm that makes use of Sk to accept in an efficient way the language of all suffixes of w up to k errors in every window of size r of a text, where r is the…

Abstract 571: The shared mutation and neoantigen landscape of MMR-deficient colorectal cancers suggests immunoediting during tumor evolution

2019

Abstract The immune system can recognize and attack cancer cells and their precursors, especially those with a high load of mutation-induced neoantigens. Such neoantigens are particularly abundant in DNA mismatch repair (MMR)-deficient cancers. MMR deficiency results in microsatellite instability (MSI), which leads to multiple insertion/deletion mutations at coding microsatellites and to neoantigen-inducing translational frameshifts. The significance of immune selection and immunoediting potentially shaping the neoantigen landscape during the progression from premalignant MMR-deficient lesions into cancers has not yet been analyzed. We hypothesized that the neoantigen landscape of MSI cance…