Search results for " Mobility"
showing 10 items of 577 documents
Genetic and Biochemical Analysis of PadR-padC Promoter Interactions during the Phenolic Acid Stress Response in Bacillus subtilis 168
2011
ABSTRACT Bacillus subtilis 168 is resistant to phenolic acids by expression of an inducible enzyme, the phenolic acid decarboxylase (PadC), that decarboxylates these acids into less toxic vinyl derivatives. In the phenolic acid stress response (PASR), the repressor of padC , PadR, is inactivated by these acids. Inactivation of PadR is followed by a strong expression of padC . To elucidate the functional interaction between PadR and the padC promoter, we performed (i) footprinting assays to identify the region protected by PadR, (ii) electrophoretic mobility shift assays (EMSAs) with a modified padC promoter protected region to determine the interacting sequences, and (iii) random mutagenesi…
Conditions of commodification : Russian as a transient commodity in an Arctic tourism resort
2022
Abstract Based on an ethnography incorporating interview, linguistic landscape and observational data, this research illustrates how temporary linguistic value is negotiated and how an Arctic tourism destination is made fit for consumption for a specific audience. Set within a tourism resort in the Finnish Arctic during two weeks in Winter when the region habitually receives a large influx of Russian-speaking visitors, we illustrate how Russian is conceptualized as a means of economic practice by stakeholders in the local tourism industry. While some offer services specifically for a Russian-speaking audience as part of a short-term high-risk/high-reward investment, others regard Russian as…
Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling.
2005
The anti-inflammatory effects of melanocortin peptides have been demonstrated in different inflammation models. This is the first report describing the molecular mechanisms for the beta-MSH-induced suppression of bacterial lipopolisaccharide (LPS)-caused brain inflammation. We found that beta-MSH suppresses LPS-induced nuclear translocation of the transcription factor NF-kappaB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain, in vivo. Moreover, administering the preferentially MC(4) receptor selective antagonist HS014 blocked completely these effects, suggesting a tentative MC(4) receptor mediated mechanism of actio…
Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle.
2004
Two studies were performed to investigate the effects of an acute bout of physical exercise on the nuclear protein kappaB (NF-kappaB) signaling pathway in rat skeletal muscle. In Study 1, a group of rats (n=6) was run on the treadmill at 25 m/min, 5% grade, for 1 h or until exhaustion (Ex), and compared with a second group (n=6) injected with two doses of pyrrolidine dithiocarbamate (PDTC, 100 mg/kg, i.p.) 24 and 1 h prior to the acute exercise bout. Three additional groups of rats (n=6) were injected with either 8 mg/kg (i.p.) of lipopolysaccharide (LPS), 1 mmol/kg (i.p.) t-butylhydroperoxide (tBHP), or saline (C) and killed at resting condition. Ex rats showed higher levels of NF-kappaB b…
Photoreactive Liquid Crystals in the Series of Dendritic and Cyclic Stilbenoid Compounds
2000
The dendrimers 1 and 2 and the areno-condensed annulenes 3 and 4 represent new mesogens for the generation of discotic mesophases. The stilbenoid building blocks of these compounds provide the molecular basis for interesting photochemical and photophysical effects like dimerisation, oligomerisation or the formation of charge carriers.
Coping with the costs of car dependency : A system of expedients used by low-income households on the outskirts of Dijon and Paris
2018
International audience; Living on low incomes and in a car-dependent area is often interpreted as a double burden for households, even if the two characteristics are often interdependent. While their capacity for mobility is lower, low-income households in outer suburban areas are nonetheless mobile. Their capacities in this domain should not be underestimated or overlooked. They can command a set of alternative practices or expedients to deal with car-related economic stress by a set of resources derived essentially from spatial proximity. This article aims to present and analyse the diversity of these expedients for the case of outer suburban areas around Paris and Dijon. The analysis of …
Reversibly stable thiopolyplexes for intracellular delivery of genes.
2006
Novel polyaspartamide non-viral carriers for gene therapy were synthesized by introducing, on the same polymer backbone, positively charged groups, for electrostatic interactions with DNA, and thiol groups for the formation of disulfide bridges between polymer chains. The introduction of thiols was aimed to have a vector with low redox potential sensitivity: disulfide crosslinking in fact, being stable in extracellular environment, allowed either to have stable complexes in plasma, that can protect DNA from metabolism, or to be reduced inside the cell, where the excess of glutathion in reduced form maintains a low redox potential. The consequent destabilization of the complex after disulfid…
Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation …
2006
Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S-adenosylmethionine, the main methyl donor. Two MAT-encoding genes (MAT1A, MAT2A) are found in mammals. The latter is expressed in proliferating liver, dedifferentiation and cancer, whereas MAT1A is expressed in adult quiescent hepatocytes. Here, we report studies on the molecular mechanisms controlling the induction of MAT2A in regenerating rat liver and in proliferating hepatocytes. The MAT2A is up-regulated at two discrete moments during liver regeneration, as confirmed by RNApol-ChIP analysis. The first one coincides with hepatocyte priming (i.e. G0-G1 transition), while the second one tak…
Personal goals and changes in life-space mobility among older people
2015
Abstract Objective Life-space mobility – the spatial extent of mobility in daily life – is associated with quality of life and physical functioning but may also be influenced by future orientation expressed in personal goals. The aim of this study was to explore how different personal goals predict changes in older people's life-space mobility. Methods This prospective cohort study with a 2-year follow-up included 824 community-dwelling people aged 75 to 90 years from the municipalities of Jyvaskyla and Muurame in Central Finland. As part of the Life-Space Mobility in Old Age study (LISPE), which was conducted between 2012 and 2014, the participants responded to the Life-Space Assessment an…
Perceived and objective entrance-related environmental barriers and daily out-of-home mobility in community-dwelling older people
2017
Abstract Purpose We studied whether entrance-related environmental barriers, perceived and objectively recorded, were associated with moving out-of-home daily in older people with and without limitations in lower extremity performance. Methods Cross-sectional analyses of the “Life-space mobility in old age” cohort including 848 community-dwelling 75–90-year-old of central Finland. Participants reported their frequency of moving out-of-home (daily vs. 0–6 times/week) and perceived entrance-related environmental barriers (yes/no). Lower extremity performance was assessed (Short Physical Performance Battery) and categorized as poorer (score 0–9) or good (score 10–12). Environmental barriers at…