Search results for " Modeling"
showing 10 items of 2411 documents
Establishing Video Game Genres Using Data-Driven Modeling and Product Databases
2015
Establishing genres is the first step toward analyzing games and how the genre landscape evolves over the years. We use data-driven modeling that distils genres from textual descriptions of a large collection of games. We analyze the evolution of game genres from 1979 till 2010. Our results indicate that until 1990, there have been many genres competing for dominance, but thereafter sport-racing, strategy, and action have become the most prevalent genres. Moreover, we find that games vary to a great extent as to whether they belong mostly to one genre or to a combination of several genres. We also compare the results of our data-driven model with two product databases, Metacritic and Mobyga…
3D survey and modelling of the main portico of the Cathedral of Monreale
2018
3D survey and modelling of Cultural Heritage allow to store a great deal of 3D data that can be managed for different purposes. 3D models can be used for documentation, restoration and knowledge of historic architectures and monuments. In this work, a 3D survey of the main portico of the Cathedral of Monreale (Palermo, Italy) was carried out. The paper presents the data acquisition process and the 3D modelling phase. The work is aimed to reconstruct a 3D model that could be used also to set up an HBIM (Heritage or Historic Building Information Modelling) of the main portico. The result of this study could be considered as a first test to implement an HBIM platform for the whole monumental c…
The possibilities of using broadleaf cattail seeds (Typha latifolia L.) as super absorbents for removing aromatic hydrocarbons (BTEX) from an aqueous…
2018
Sorption of oil-related products (including mainly the propellants) is the very basic process that counteracts spreading these types of pollution into environment. Plenty of synthetic substances (including the monoaromatic hydrocarbons) are both from the surface and underground waters. The aim of this study was to present the research’s results on the possibilities of using the broadleaf cattail (Typha latifolia L.) seeds as a sorbent of monoaromatic hydrocarbons from an aqueous solution. In order to increase sorptive capacity, the seeds biomass was submitted for the process of mercerizing in diversified time and temperature in water and the NaOH solution. The removal of benzene, toluene, e…
E.O.-based estimation of transpiration and crop water requirements for vineyards: a case study in southern Italy
2014
An efficient use of water for irrigation is a challenging task. From an agronomical point of view, it requires establishing the optimal amount of water to be supplied, at the correct time, based on phenological phase and water stress spatial distribution. Indeed, the knowledge of the actual water stress is essential for agronomic decisions, vineyards need to be managed to maintain a moderate water stress, thus allowing to optimize berries quality and quantity. Methods for quickly quantifying where, when and in what extent, vines begin to experience water stress are beneficial. Traditional point based methodologies, such those based on Scholander pressure chamber, even if well established ar…
EFFECTS OF CUSTOMER KNOWLEDGE MANAGEMENT AND CUSTOMER ORIENTATION ON INNOVATION CAPACITY AND MARKETING RESULTS IN SMEs: THE MEDIATING ROLE OF INNOVAT…
2018
Managing customer knowledge is a key of source for SMEs. The principal aim of this paper is to provide empirical evidence on the direct effects of two specific strategic resources: customer orientation and customer knowledge management (CKM), on innovation capacity and marketing results in SMEs. The study also examines the role of innovation orientation as a mediator between customer orientation and CKM. For this purpose, a structural model was proposed and tested through an empirical investigation with variance-based structural equation modeling (PLS) using a sample made up of 210 Spanish SMEs. The findings highlight the relevance of CKM and customer orientation as important strategic res…
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1
2003
Changes in DNA methylation patterns play an important role in tumorigenesis. The DNA methyltransferase 1 (DNMT1) protein represents a major DNA methyltransferase activity in human cells and is therefore a prominent target for experimental cancer therapies. However, there are only few available inhibitors and their high toxicity and low specificity have so far precluded their broad use in chemotherapy. Based on the strong conservation of catalytic DNA methyltransferase domains we have used a homology modeling approach to determine the three-dimensional structure of the DNMT1 catalytic domain. Our results suggest an overall structural conservation with other DNA methyltransferases but also in…
Never Cared for What They Do: High Structural Stability of Guanine-Quadruplexes in the Presence of Strand-Break Damage
2022
DNA integrity is an important factor that assures genome stability and, more generally, the viability of cells and organisms. In the presence of DNA damage, the normal cell cycle is perturbed when cells activate their repair processes. Although efficient, the repair system is not always able to ensure complete restoration of gene integrity. In these cases, mutations not only may occur, but the accumulation of lesions can either lead to carcinogenesis or reach a threshold that induces apoptosis and programmed cell death. Among the different types of DNA lesions, strand breaks produced by ionizing radiation are the most toxic due to the inherent difficultly of repair, which may lead to genomi…
Spatial and temporal changes in Actinobacterial dominance in experimental artificial groundwater recharge.
2008
Abstract Artificial groundwater recharge (AGR) is used in the drinking water industry to supplement groundwater resources and to minimise the use of chemicals in water treatment. This study analysed the spatial and temporal changes of microbial communities in AGR using two test systems: a nutrient-amended fluidized-bed reactor (FBR) and a sand column. Structural changes in the feed lake water (Lake Roine), FBR, and sand column bacterial communities were determined by denaturing gradient gel electrophoresis (DGGE) and the length heterogeneity analysis of amplified 16S rRNA genes (LH-PCR). Two clone libraries were created to link the LH-PCR results to the dominant bacterial groups. The lake w…
Microbial diversity in a thermophilic aerobic biofilm process: analysis by length heterogeneity PCR (LH-PCR).
2003
A two-stage pilot-scale thermophilic aerobic suspended carrier biofilm process (SCBP) was set up for the on-site treatment of pulp and paper mill whitewater lining. The microbial diversity in this process was analyzed by length heterogeneity analysis of PCR-amplified 16S ribosomal DNA. The primer pair selected for PCR amplification was first evaluated by a computational analysis of fragment lengths in ten main phylogenetical eubacterial groups. The fragment contained the first third of the 16S rRNA gene, which was shown to vary naturally between 465 and 563 bp in length. The length heterogeneity analysis of polymerase chain reaction (LH-PCR) profile of the biomass attached to carrier elemen…
Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches
2013
The tyrosinase gene from Ralstonia solanacearum (GenBank NP518458) was subjected to random mutagenesis resulting in tyrosinase variants (RVC10 and RV145) with up to 3.2-fold improvement in kcat, 5.2-fold lower Km and 16-fold improvement in catalytic efficiency for D-tyrosine. Based on RVC10 and RV145 mutated sequences, single mutation variants were generated with all variants showing increased kcat for D-tyrosine compared to the wild type (WT). All single mutation variants based on RV145 had a higher kcat and Km value compared to the RV145 and thus the combination of four mutations in RV145 was antagonistic for turnover, but synergistic for affinity of the enzyme for D-tyrosine. Single muta…