Search results for " Modeling"
showing 10 items of 2411 documents
Use of new technique of image based aimed to perspective return
2014
The diffusion of Image-based 3D modeling techniques, through image-based free, low cost and open source software, have increased drastically in the past few years, especially in Cultural Heritage domain (Architecture, Archeology, Urban planning) [2, 3]. Computer vision techniques use photographs from dataset collection to rapidly build detailed 3D models. The simultaneous applications of different algorithms (MVS), the different techniques of image matching, feature extracting and mesh optimization are inside an active field of research in computer vision. Computer vision techniques - Structure from Motion (SfM)- allow to fulfill detailed 3D models from photos dataset collections. The resul…
Modélisation d'images agronomiques - application a la reconnaissance d'adventices par imagerie pour une pulvérisation localisée
2009
Plant (crop and weed) identification is a very active field of research in agriculture since the reinforcement of European laws about pesticide applications for a site-specific management of spraying practices. A new crop/weed simulation model was developed to allow the evaluation of crop/weed spatial identification methods from imaging. Considering multiples agronomic parameters – crop location, weed infestation rate, weed spatial distribution – the first step of this model allows the simulation of an infested crop field. Then, in a second step, a world to camera transformation is applied to allow every kind of picture (with or without perspective effect). The validation of this model was …
The role of depression and impulsivity in the psychopathology of bulimia nervosa.
2013
Introduction: The study aimed to analyze the role of depression and impulsivity in the psychopathology of bulimia nervosa (BN). Materials and methods: Seventy female patients with DSM-IV BN, purging subtype, were assessed for eating-related symptoms, body dissatisfaction, affective symptoms, impulsivity, and personality traits. Factor analysis and structural equation modeling methods were used for statistical analysis. Results: BN appeared as a condition which incorporated 5 general dimensions: a) binge eating and compensatory behaviours; b) restrictive eating; c) body dissatisfaction; d) dissocial personality traits; and e) a cluster of features which was called "emotional instability" The…
Indole-substituted 2,4-diamino-5,8-dihydropyrido[2,3-d]pyrimidines from one-pot process and evaluation of their ability to bind dopamine receptors
2018
A series of novel 7-indole substituted 2,4-diamino-5,8-dihydropyrido[2,3-d]pyrimidine analogous to the 2,4-diaminopteridine core were synthesized by the three-component one-pot cyclocondensation between 2,4,6-triaminopyrimidine, 3-(2-cyanoacetyl)indole and aromatic aldehydes. The reactions, which exhibited good performance, proceeded in EtOH using indium (III) chloride as catalyst under microwave irradiation, in short reaction times. On the basis of certain structural similarity of these compounds with known ligands of the D2 dopamine receptors (D2DR), the study of these compounds as possible ligands of dopamine D2 and D1 receptors was carried out. Three of them showed moderate affinity to …
Molecular modeling approaches in the discovery of new drugs for anti-cancer therapy: the investigation of p53-MDM2 interaction and its inhibition by …
2010
The mdm2 oncogene product, MDM2, is an ubiquitin protein ligase that inhibits the transcriptional activity of the tumor suppressor p53 and promotes its degradation. About 50% of all human cancers present mutations or deletions in the TP53 gene. In the remaining half of all human neoplasias that express the wild-type protein, aberrations of p53 regula- tors, such as MDM2, account for p53 inhibition. For this reason, designing small-molecule inhibitors of the p53-MDM2 protein-protein interaction is a promising strategy for the treatment of cancers retaining wild-type p53. The development of inhibitors has been challenging. Although many small-molecule MDM2 inhibitors have shown potent in vitr…
Experiment of Indoor Thermal Optimization of an Old Historic Building of Cluny through Digital Mock-up Simulation
2013
International audience; Improving energy efficiency is the first and most important step toward achieving sustainability in buildings. Buildings designed with sustainable solutions are usually energy-efficient because sustainable design is aimed at producing green buildings. In the case of historic buildings, however, this is quite challenging. Integrated building energy simulation programs have been used in various ways by building professionals to respond to these challenges and to improve building design with respect to sustainability. This poster presents a new approach toward optimizing thermal indoor energy using a digital mock-up simulation of a historical building to explore its pot…
Efeitos das práticas verdes na lealdade: proposta de um modelo para o segmento hoteleiro colombiano
2021
Resumen El propósito de este estudio fue analizar la incidencia de las prácticas verdes como impulsoras para generar confianza, satisfacción y lealtad en los huéspedes. Para ello, a partir de una muestra de 302 huéspedes de hoteles en Bogotá, Colombia, se estimó un modelo de ecuaciones estructurales a través de la regresión de mínimos cuadrados parciales. Los resultados obtenidos evidencian que las prácticas sostenibles contribuyen al aumento de la confianza y la satisfacción de los huéspedes, y que estas, a su vez, influyen positivamente en su lealtad hacia el hotel. Además, dichos resultados ponen de manifiesto que una comprensión más profunda del perfil de los turistas medioambientalment…
Reti: CIB W78: 32nd international conference in “Information Technology for Construction”, Eindhoven, Netherlands, October 2015
2016
Building Information Modeling (BIM) is an emerging methodology in the building industry, since the intelligent digital three-dimensional model-based process of BIM can be used to plan, design, structure, manage, and analysis buildings. The aim of this report paper is to provide information about the latest related topic in BIM field connecting to CIB W78 conferenece.
Empirical Equations for the Direct Definition of Stress–Strain Laws for Fiber-Section-Based Macromodeling of Infilled Frames
2018
Equivalent strut macromodels are largely used to model the influence of infill walls in frame structures due to their simplicity and effectiveness from a computational point of view. Despite these advantages, which are fundamental to carrying out seismic simulation of complex structures, equivalent struts are phenomenological models and therefore have to conventionally account for the influence of really large amounts of geometrical and mechanical variables with a relatively simple inelastic response. Mechanical approaches, generally used to evaluate the force-displacement curve of a strut, are based on hypothesizing the damage mechanism that will occur for an infill-frame system subject to…
Computational methodologies applied to Protein-Protein Interactions for molecular insights in Medicinal Chemistry
2021
In living systems, proteins usually team up into “molecular machinery” implementing several protein-to-protein physical contacts – or protein-protein interactions (PPIs) – to exert biological effects at both cellular and systems levels. Deregulations of protein-protein contacts have been associated with a huge number of diseases in a wide range of medical areas, such as oncology, cancer immunotherapy, infectious diseases, neurological disorders, heart failure, inflammation and oxidative stress. PPIs are very complex and usually characterised by specific shape, size and complementarity. The protein interfaces are generally large, broad and shallow, and frequently protein-protein contacts are…