Search results for " Models"

Long-lived particles at the energy frontier: the MATHUSLA physics case

2019

We examine the theoretical motivations for long-lived particle (LLP) signals at the LHC in a comprehensive survey of Standard Model (SM) extensions. LLPs are a common prediction of a wide range of theories that address unsolved fundamental mysteries such as naturalness, dark matter, baryogenesis and neutrino masses, and represent a natural and generic possibility for physics beyond the SM (BSM). In most cases the LLP lifetime can be treated as a free parameter from the $\mu$m scale up to the Big Bang Nucleosynthesis limit of $\sim 10^7$m. Neutral LLPs with lifetimes above $\sim$ 100m are particularly difficult to probe, as the sensitivity of the LHC main detectors is limited by challenging …

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.

2001

Interleukin (IL)-18, initially described as interferon (IFN)-gamma-inducing factor, is expressed in the inflamed mucosa of patients with Crohn's disease. To investigate the role of IL-18 in intestinal inflammation, the effect of neutralizing antimurine IL-18 antiserum in dextran sulfate sodium (DSS)-induced colitis in BALB/c and C57BL/6 mice was examined. During a dose response of DSS, levels of colonic IL-18 increased parallel with clinical worsening. With the use of confocal laser microscopy, the increased IL-18 was localized to the intestinal epithelial layer. Anti-IL-18 treatment resulted in a dose-dependent reduction of the severity of colitis in both BALB/c and C57BL/6 mice. Colon sho…

Transgenerational effects of plant sex and arbuscular mycorrhizal symbiosis

2013

In gynodioecious plants, females are predicted to produce more and/or better offspring than hermaphrodites in order to be maintained in the same population. In the field, the roots of both sexes are usually colonized by arbuscular mycorrhizal (AM) fungi. Transgenerational effects of mycorrhizal symbiosis are largely unknown, although theoretically expected. We examined the maternal and paternal effects of AM fungal symbiosis and host sex on seed production and posterior seedling performance in Geranium sylvaticum, a gynodioe- cious plant. We hand-pollinated cloned females and hermaphrodites in symbiosis with AM fungi or in nonmycorrhizal conditions and measured seed number and mass, and see…

Protective effect of apocynin in a mouse model of chemically-induced colitis.

2013

Apocynin, a constituent of Picrorhiza kurroa, successfully inhibits NADPH oxidase and shows promise as an anti-inflammatory drug. Now, we report anti-inflammatory effects of apocynin in an experimental colitis model induced by dextran sulfate sodium as well as the effects on the mediators involved in this process. Apocynin reduced the colitis induced in mice by administration of 5 % dextran sulfate sodium during 7 days. Mice were fed a control diet or a diet supplemented with 2 % of apocynin or 2 % of rutin. Sulfasalazine (50 mg/kg, p. o.) was used as a positive control. Treatment with apocynin and rutin ameliorated the course of colonic inflammation with results similar to those of the ref…

Minimum Description Length Based Hidden Markov Model Clustering for Life Sequence Analysis

2010

In this article, a model-based method for clustering life sequences is suggested. In the social sciences, model-free clustering methods are often used in order to find typical life sequences. The suggested method, which is based on hidden Markov models, provides principled probabilistic ranking of candidate clusterings for choosing the best solution. After presenting the principle of the method and algorithm, the method is tested with real life data, where it finds eight descriptive clusters with clear probabilistic structures. nonPeerReviewed

Assessment of tools for urban energy planning

2019

Abstract In recent years, studies and policies have encouraged the diffusion of distributed energy supply technologies and large integration of renewable sources. This increases the need for new professionals in energy planning. Several computational tools for energy planning have been developed as described in the technical literature. However, energy planners of urban/district areas engaged in the transition towards smart systems related to buildings energy services require well-documented tools to evaluate the combination of available energy sources by proper conversion technologies. With this, after a scientific review, we selected 17 tools targeted on an urban/districts scale that can …

Tomography Application to Complex Seismic Data of the Tjornes Fracture Zone (Iceland)

2014

The Tjornes Fracture Zone (TFZ) is an active seismic zone in Northeast Iceland. It plays a key role to understand the geodynamic movement and location of tectonic plates. However the seismic experiment can not be performed close to earthquake sources, because sources are mainly located in the Greenland Sea. The unusual geological structure of TFZ and the limited conditions of an experiment lead to significant deviations between real observations and the values that are calculated in accordance with theoretical models. Consequently, there is a loss of adequacy and stability of tomography systems. Outcomes of the method, which takes into account this problem, are analyzed in the present chapt…

Platelet function testing in pigs using the Multiplate® Analyzer.

2019

PLOS ONE 14(8), e0222010 (2019). doi:10.1371/journal.pone.0222010

Vertical movements of the Paris Basin (Triassic-Pleistocene): from 3D stratigraphic database to numerical models

2003

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

2014

Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal …