Search results for " Models"
showing 10 items of 4240 documents
The destiny of the subjectivity and the life of relationship in the globalized financial economic device.
2012
The present contribution intends to introduce to a reflection on the relationship between culture and personality, on the historicity of the contents that structure all the different levels of subjectivity (individual, interpersonal and transpersonal) beginning from the experience of the EATGA Workshop 2011 that took place in Palermo and that hads as its theme “Intersubjective bonds in the globalized economy”. Following studies and research on the role of the cultural phenomena in the formation of the psyche, in the life of relationship and in the work of transcultural analysis, the EATGA Workshop 2011 have introduced important elements of discontinuity. The theme, that structures the exper…
Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma
2002
The p16INK4a gene, localized within chromosome 9p21, has been identified as a cyclin-dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series of 64 untreated patients (median of follow up 53 months) undergoing surgical resection for locally advanced laryngeal squamous-cell carcinomas (LSCCs) has been studied prospectively. Our purpose was to investigate p16 alterations (9p21 allelic loss, hypermethylation and point mutations) and their possible association with clinico-pathological data and flow cytometric variables (DNA-ploidy and S-phase fraction (SPF)…
Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferati…
2023
The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disadvantageous physico–chemical properties, leading to restricted clinical use. In this work, a complex mixture of PEGylated lipid, Glyceryl monoester, 18-β-Glycyrrhetinic Acid and Menthol was designed to entrap Resveratrol (RSV) as the active ingredient and further produce lipid nanoparticles (LNPs) by homogenization followed by high-freq…
Lipid and apoprotein composition of HDL in partial or complete CETP deficiency
2012
Hyperalphalipoproteinemia, as observed in patients who are either homozygous or heterozygous for cholesteryl ester transfer protein (CETP) deficiency, has been shown to be associated with striking changes in apolipoprotein size distribution, namely, of high-density lipoprotein (HDL) and HDL-like particles. We compared the effect of varying degrees of CETP activity on the HDL apolipoprotein profile in Caucasian CETP-deficient subjects and following pharmacological decrease in CETP activity, using Size Exclusion Chromatography followed by Reverse Phase Protein Array (SEC RPA). The main HDL-associated apolipoproteins (Apo), i.e. ApoA-I, ApoA-II, ApoC-I, and ApoC-III, co-eluted with the HDL pea…
The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study
2021
Objectives: In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for heart health (URRAH) study. Methods: Eight thousand URRAH participants aged 65+ were included in the analysis. The predictive role of SUA was assessed using Cox regression models stratified according to the cut-off age of 75. SUA was tested as continuous and categorical variable (age-specific quartiles). The prognostic threshold of SUA for mortality was analysed using receiver operating characteristic …
Decellularized Saphena: Biologic Scaffold for 3D Cellular Growth
2016
Neuroprotective properties of xenon and helium in an in vitro model of traumatic brain injury: one small step or one big jump?
2008
Fiscal Policy and Asset Price Cycles: Evidence from Four European Countries
2014
OS; International audience; We test for non-linear effects of asset prices on the fiscal policy of four major European economies (France, Italy, Spain and UK). We model government spending and revenue as time-varying transition probability Markovian processes (TVPMS), and find that: (i) in France and Italy, the impact of housing prices on government revenue is conditioned by the phase of the stock price cycle; (ii) a similar asymmetric pattern is found for the UK when considering the effect of stock price fluctuations on government revenue and spending vis-à-vis the troughs and peaks of aggregate wealth; and (iii) for Spain, a fall in government revenue is typically associated with a negati…
ESSAYS ON FINANCIAL STRESS: A MIXED FREQUENCY DATA ANALYSIS
Turning a business idea into a real business through an entrepreneurial learning approach based on dynamic start-up business model simulators
2017
In this paper we argue that the use of System Dynamics modelling applied to Business Model design and representation may result in an entrepreneurial learning approach to support potential entrepreneurs in exploring and learn how a business operates and reacts according to alternative strategic choices. As such, a Dynamic Business Modelling approach provides useful insights to start-up entrepreneurs learning processes by capturing and explaining how critical Business Model elements interact to produce enduring competitive advantages over time.