Search results for " Models"
showing 10 items of 4240 documents
Non-Linear Hysteretic Instability in Rotating Machinery
2013
Droghe leggere e criminalità organizzata: una relazione problematica
2022
Il contributo analizza il tema dei rapporti tra trattamento penale delle droghe c.d. “leggere” e contrasto alla criminalità organizzata dedita al narcotraffico, con riguardo all’ordinamento europeo, internazionale e di alcuni Paesi dell’UE (Spagna, Portogallo, Grecia, Germania e Italia). Seguendo un approccio di tipo integrato, all’analisi del dato normativo si affianca la descrizione della fenomenologia dei traffici e la valutazione dei primi effetti che le riforme antiproibizioniste entrate in vigore in alcuni ordinamenti del Nord e del Sud America hanno prodotto sul fronte del mercato illecito. Il fine è di evidenziare i punti di forza e di debolezza dei modelli di depenalizzazione, tene…
La cattedrale di Palermo
2015
Il volume ripercorre le principali vicende architettoniche della cattedrale di Palermo dalle origini fino al Novecento, individuandone nella sua complessa storia plurisecolare i committenti, gli artefici e i modelli di riferimento.
On the Influence of Technology on Learning Processes
2014
Probabilistic computations and frequency computations were invented for the same purpose, namely, to study possible advantages of technology involving random choices. Recently several authors have discovered close relationships of these generalizations of deterministic computations to computations taking advice. Various forms of computation taking advice were studied by Karp and Lipton [1], Damm and Holzer [2], and Freivalds [3]. In the present paper, we apply the nonconstructive, probabilistic, and frequency methods to an inductive inference paradigm originally due to Gold [4] and investigate their impact on the resulting learning models. Several trade-offs with respect to the resulting l…
Surface plasmon interference fringes in back-reflection
2010
We report the experimental observation of surface plasmon polariton (SPP) interference fringes with near-unity visibility and half-wavelength periodicity obtained in back reflection on a Bragg mirror. The presented method based on leakage radiation microscopy (LRM) represents an alternative solution to optical near-field analysis and opens new ways for the quantitative analysis of SPP fringes. With LRM we investigate various SPP interference patterns and analyze the high reflectivity of Bragg mirror in comparison with theoretical models.
Comparison of different revenue models in SaaS
2012
Cloud computing brings new possibilities for software firms to sell their products within a Software-as-a-Service (SaaS) model. However, although SaaS provides new revenue models, it may not easily achieve a profitable revenue stream. For customers, SaaS promises cost savings related to IT expenses. However, it may be difficult to estimate which revenue model will be best for a given situation. In this paper I present the common revenue models used in SaaS, examining their advantages and disadvantages from the point of view of the software provider and the customer. Keywords-Revenue models, SaaS, Cloud computing, Business in cloud
Numerical models for long-term performance assessment of lightweight insulating assemblies
2019
Abstract This paper presents the results of numerical modelling of hygrothermal processes in test buildings situated in the Botanical garden of the University of Latvia. Long-term performance of wall, floor and ceiling insulating assemblies for five different buildings was simulated using WUFI Pro 6.3. On the experimental side, measurements of temperature and relative humidity at key points of assembles have been accumulated over a period of roughly six years and material samples were taken from building envelope materials for biological analysis. We found that our models rather successfully reproduce the experientially observed temperature and relative humidity dynamics. In the process, we…
Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis
2014
AbstractRedox control of proteins that form disulfide bonds upon oxidative challenge is an emerging topic in the physiological and pathophysiological regulation of protein function. We have investigated the role of the neuronal calcium sensor protein visinin-like protein 1 (VILIP-1) as a novel redox sensor in a cellular system. We have found oxidative stress to trigger dimerization of VILIP-1 within a cellular environment and identified thioredoxin reductase as responsible for facilitating the remonomerization of the dimeric protein. Dimerization is modulated by calcium and not dependent on the myristoylation of VILIP-1. Furthermore, we show by site-directed mutagenesis that dimerization is…
Experimental Investigation of the Shear Response of Precast Steel-Concrete Trussed Beams
2017
The results of an experimental campaign of three-point bending tests on precast composite beams, named hybrid steel-trussed concrete beams (HSTCBs), are provided. HSTCBs are typically constituted by a precast steel truss embedded in a block of concrete cast in place. Two series of specimens were manufactured, designed such that shear failure would occur, and tested under positive and negative bending moment. The experimental results obtained showed that fragile shear failure occurred in almost all cases, evidencing the crisis of the compressed concrete strut involved in the collapse mechanism. Yielding of the steel members provided ductility to the system, especially in those cases in which…
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
2011
BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METHODOLOGY/PRINCIPAL FINDINGS: We used an in vitro model of the neurovascular unit and the guinea pig whole brain preparation to analyze with immunohistochemical methods the BBB properties and neurovascular integrity. In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by…