Search results for " Models"
showing 10 items of 4240 documents
Prognosis of resected intrahepatic cholangiocarcinoma
2017
Introduction. Complete resection stands as the only curative option for intrahepatic cholangiocarcinoma (IHCC). Still, prognosis remains poor after resection due to a recurrence rate over 60% leading to actual 5-year survival rates below 20%. Reliable prognostic estimation and better understanding of tumor biology would be of interest for improving IHCC prognosis.Methods. Using clinical and biological data from two large cohort of resected IHCC (MSKCC, n=189 and AFC, n=522), three objectives have been explored. First, assessing the performances of different published prognostic models. Second, defining the reliability of preoperative prognostic estimation using imaging, tumoral genomic prof…
Analyze and simulation a dynamic of soil indicators fertility under different agricultural management practices in cotton area of Togo
2011
Using data observed during 20 to 40 years in different agro-ecosystems of Togo, we analyzed soil fertility dynamic under different agricultural management practices. Tree soil C models of varying complexity were tested, and the most accurate in terms of soil C dynamics description in these tropical soils was associated with the QUEFTS model and with nutrient partial balance to analyze the effect of each agricultural management practice. Results indicated that, although fertilizers N, P and K were continuously applied at a recommended rate by the research (RR) or at this rate increased in 50% (1.5RR), initial cotton and cereals yields of 1.5 to 2 t ha˗1 and 2 to 3 t ha˗1, respectively, decre…
A priori parameterisation of the CERES soil-crop models and tests against several European data sets
2002
Mechanistic soil-crop models have become indispensable tools to investigate the effect of management practices on the productivity or environmental impacts of arable crops. Ideally these models may claim to be universally applicable because they simulate the major processes governing the fate of inputs such as fertiliser nitrogen or pesticides. However, because they deal with complex systems and uncertain phenomena, site-specific calibration is usually a prerequisite to ensure their predictions are realistic. This statement implies that some experimental knowledge on the system to be simulated should be available prior to any modelling attempt, and raises a tremendous limitation to practica…
Assessment of Adult Mouse Brain Neuroanatomical Phenotypes Using Quantitative and Precision Histology
2022
Modelling human neurodevelopmental disorders is important in biomedical research since the brain cannot be easily accessed in humans. In this chapter, we describe a series of standardized procedures for the reliable analysis of neuroanatomical phenotypes (NAPs) of the adult mouse brain using quantitative 2D histological practices. Our goal is to provide the reader an experimental pipeline, ranging from experimental work through to data analysis, which can be performed in any academic research setting with or without access to a histology platform. Depending on the type of sections studied, parasagittal or coronal, the assessment of brain neuroanatomy is performed at stereotaxic sections, at…
Ex ante evaluation of gene flow in oilseed rape with cropping sytem models
2009
International audience
Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
2015
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventricular tachycardia, and carries a high risk of sudden cardiac death. Despite its importance, very few animal model studies have focused on the heart dysfunction in DM1. Here, we describe the characterization of the heart phenotype in a Drosophila model expressing pure expanded CUG repeats under the control of the cardiomyocyte-specific driver GMH5-Gal4. Morphologically, expression of 250 CUG repeat…
Environmental spillovers and their impacts on housing prices: A spatial hedonic analysis
2015
This paper investigates the spatial dimension of environmental factors on housing prices. We develop spatial hedonic models to estimate the implicit prices of various environmental attributes. The spatial dimension can be interpreted in terms of local or global spillovers. We conduct an empirical study in the Loire estuary (France). We focus on natural areas and more artificialized ones (ocean frontage, wetlands, rivers, and noisy roads). We show that, depending on the spatial model used, the implicit price is more than just the estimated coefficient value and combines both a feedback effect and a propagation effect.
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome
2014
Fetal alcohol spectrum disorder (FASD) is a frequent cause of mental retardation. However, the molecular mechanisms underlying brain development defects induced by maternal alcohol consumption during pregnancy are unclear. We used normal and Hsf2-deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure. Upon fetal alcohol exposure, HSF2 is essential for the triggering of HSF1 activation, which is accompanied by distinctive post-translational modifications, and HSF2 steers the formation of atypical alcohol-specific HSF1–HSF2 heterocomplexes. This perturbs the in vivo bindi…
Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process
2012
International audience; Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by penetrating through epithelial barriers. C. albicans is a remarkable pathogen because it can invade epithelial cells via two distinct mechanisms: induced endocytosis, analogous to facultative intracellular enteropathogenic bacteria, and active penetration, similar to plant pathogenic fungi. Here we investigated the contributions of the two invasion routes of C. albicans to epithelial invasion. Using selective cellular inhibition approaches and differential fluorescence microscopy, we demonstrate that induced endocytosis contri…
Peer effects in the light of students interactions and the subjective dimensions of school experience
2011
This Thesis addresses the issue of peer-effects in the context of school. From analysis of a large database produced by a Chilean national study (SIMCE 2004), this work investigates the mechanisms through which pupils with different levels of scholastic, human and cultural capital influence each other. These influences seem present for a diverse range of school outcomes, including academic achievement. Drawing on the literature produced by different disciplinary approaches —sociology, economics, social psychology and education— the study focuses on ways of identifying and measuring peer-effects. The presence of subjective dimensions capable of reflecting, in part, the school experience of p…