Search results for " Models"
showing 10 items of 4240 documents
HOWERD: A Hidden Markov Model for Automatic OWL-ERD Alignment
2016
The HOWERD model for estimating the most likely alignment between an OWL ontology and an Entity Relation Diagram (ERD) is presented. Automatic alignment between relational schema and ontology represents a big challenge in Semantic Web research due to the different expressiveness of these representations. A relational schema is less expressive than the ontology; this is a non trivial problem when accessing data via an ontology and for ontology storing by means of a relational schema. Existent alignment methodologies fail in loosing some contents of the involved representations because the ontology captures more semantic information, and several elements are left unaligned. HOWERD relies on a…
Implicit perception simplicity and explicit perception complexity in sensorimotor communication: Comment on "The body talks: Sensorimotor communicati…
2019
[No abstract available]
Information Transfer in Linear Multivariate Processes Assessed through Penalized Regression Techniques: Validation and Application to Physiological N…
2020
The framework of information dynamics allows the dissection of the information processed in a network of multiple interacting dynamical systems into meaningful elements of computation that quantify the information generated in a target system, stored in it, transferred to it from one or more source systems, and modified in a synergistic or redundant way. The concepts of information transfer and modification have been recently formulated in the context of linear parametric modeling of vector stochastic processes, linking them to the notion of Granger causality and providing efficient tools for their computation based on the state&ndash
Tissue‐dependent differences in Bardet–Biedl syndrome gene expression
2019
BACKGROUND INFORMATION Primary cilia are highly conserved multifunctional cell organelles that extend from the cell membrane. A range of genetic disorders, collectively termed ciliopathies, is attributed to primary cilia dysfunction. The archetypical ciliopathy is the Bardet-Biedl syndrome (BBS), patients of which display virtually all symptoms associated with dysfunctional cilia. The primary cilium acts as a sensory organelle transmitting intra- and extracellular signals thereby transducing various signalling pathways facilitated by the BBS proteins. Growing evidence suggests that cilia proteins also have alternative functions in ciliary independent mechanisms, which might be contributing …
Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila
2007
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and furthe…
Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential r…
2012
Abstract Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, metabolic alterations, and early cardiovascular complications. Both LMNA-linked lipodystrophies are characterized by the accumulation of the lamin A precursor prelamin A. The pathological mechanism by which prelamin A accumulation induces the lipodystrophy associated phenotypes remains unclear. Since the affected tissues in these disorders are of mesenchymal origin, we…
Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…
2018
ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…
Computational methods and theory for ion channel research
2022
Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.
I luoghi del malinteso nella cultura e nella cura
2015
This article focuses on cultural misunderstanding in care relations, starting from the analysis of the effects misunderstanding causes in the relation between doctor and migrant patient. The Western medical model tends to be based on objective data, which can be diagnosed through more and more precise and detailed techniques, but it excludes from care relations human and cultural aspects of subjectivity and relation. This exclusion creates distance, which increases when doctor and patient do not share a cultural homogeneity but differ for their language and the way they conceive their body, health, disease. By showing some clinical examples, this contribution points out how specialized comp…
Misunderstanding Situations in Culture and Cultural Care
2017
This article focuses on cultural misunderstanding in care relations, starting from the analysis of the effects misunderstanding causes in the relation between doctor and migrant patient. The Western medical model tends to be based on objective data, which can be diagnosed through more and more precise and detailed techniques, but it excludes human and cultural aspects of subjectivity and relation from care. This exclusion creates distance, which increases when doctor and patient do not share a cultural homogeneity but differ for their language and the way they conceive their body, health, and disease. By showing some clinical examples, this contribution points out how specialized competence…