Search results for " Models"
showing 10 items of 4240 documents
An explicit mechanical interpretation of Eringen non-local elasticity by means of fractional calculus
2009
If the attenuation function of strain is expressed as a power law, the formalism of fractional calculus may be used to handle Eringen non-local elastic model. Aim of the present paper is to provide a mechanical interpretation to this non-local fractional elastic model by showing that it is equivalent to a discrete, point-spring model. A one-dimensional geometry is considered; static, kinematic and constitutive equations as well as the proper boundary conditions are derived and discussed.
Impact of
2018
Drosophila melanogaster has been for over a century the model of choice of several neurobiologists to decipher the formation and development of the nervous system as well as to mirror the pathophysiological conditions of many human neurodegenerative diseases. The rare disease Friedreich’s ataxia (FRDA) is not an exception. Since the isolation of the responsible gene more than two decades ago, the analysis of the fly orthologue has proven to be an excellent avenue to understand the development and progression of the disease, to unravel pivotal mechanisms underpinning the pathology and to identify genes and molecules that might well be either disease biomarkers or promising targets for therap…
Observation of the rare B(s)(0) + decay from the combined analysis of CMS and LHCb data.
2015
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported licence.-- et al.
Experimental investigation of the 0⁺₂ band in ¹⁵⁴Sm as a β-vibrational band
2014
Estimation of sparse generalized linear models: the dglars package
2013
dglars is a public available R package that implements the method proposed in Augugliaro, Mineo and Wit (2013) developed to study the sparse structure of a generalized linear model. This method, called dgLARS, is based on a differential geometrical extension of the least angle regression method (LARS). The core of the dglars package consists of two algorithms implemented in Fortran 90 to efficiently compute the solution curve; specifically a predictor-corrector algorithm and a cyclic coordinate descent algorithm.
Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa
2011
For dominantly inherited disorders development of gene therapies, targeting the primary genetic lesion has been impeded by mutational heterogeneity. An example is rhodopsin-linked autosomal dominant retinitis pigmentosa with over 150 mutations in the rhodopsin gene. Validation of a mutation-independent suppression and replacement gene therapy for this disorder has been undertaken. The therapy provides a means of correcting the genetic defect in a mutation-independent manner thereby circumventing the mutational diversity. Separate adeno-associated virus (AAV) vectors were used to deliver an RNA interference (RNAi)-based rhodopsin suppressor and a codon-modified rhodopsin replacement gene res…
Testing chemical carcinogenicity by using a transcriptomics HepaRG-based model?
2014
The EU FP6 project carcinoGENOMICS explored the combination of toxicogenomics and in vitro cell culture models for identifying organotypical genotoxic- and non-genotoxic carcinogen- specific gene signatures. Here the performance of its gene classifier, derived from exposure of metabolically competent human HepaRG cells to prototypical non-carcinogens (10 compounds) and hepatocarcinogens (20 compounds), is reported. Analysis of the data at the gene and the pathway level by using independent biostatistical approaches showed a distinct separation of genotoxic from non-genotoxic hepatocarcinogens and non-carcinogens (up to 88 % correct prediction). The most characteristic pathway responding to …
Esa's SMOS Mission – Supporting Agricultural Applications
2018
The European Space Agency's (ESA) SMOS mission, in orbit since more than 8 years, carries a passive microwave interferometric radiometer measuring in L-Band and provides accurate global observations of emitted radiation originating from the Earth's surfaces since the atmosphere is almost transparent in this spectral range. In addition, over land the effect of vegetation on the measurements is smaller than for shorter wavelengths. The scientific objectives of the SMOS mission directly respond to the need for global observations of soil moisture and ocean salinity, two key variables used in predictive hydrological, oceanographic and atmospheric models. SMOS observations also provide informati…
A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube
2012
An important step in epithelial organ development is size maturation of the organ lumen to attain correct dimensions. Here we show that the regulated expression of Tenectin (Tnc) is critical to shape the Drosophila melanogaster hindgut tube. Tnc is a secreted protein that fills the embryonic hindgut lumen during tube diameter expansion. Inside the lumen, Tnc contributes to detectable O-Glycans and forms a dense striated matrix. Loss of tnc causes a narrow hindgut tube, while Tnc over-expression drives tube dilation in a dose-dependent manner. Cellular analyses show that luminal accumulation of Tnc causes an increase in inner and outer tube diameter, and cell flattening within the tube wall,…
How strategic needs influence alliance formation and their governance modes: An empirical study in the Italian biopharmaceutical industry
2011
Firms enter strategic alliances for various reasons, and the motives behind formation of these alliances are one of main research subjects in the management field. The large literature on the issue has highlighted how alliances answer to a strategic need for collaboration that is the need to improve competitive strength through collaboration agreements. However, the study here addresses the strategic need perspective to alliances under a more specific point of view. We question what kind of competitive strengths firms aim at acquiring through inter-firm relationships. By reviewing of the most relevant literature on the issue we assume that alliances respond to three principal strategic need…