Search results for " Models"
showing 10 items of 4240 documents
INFERRING GENE NETWORKS FROM MICROARRAY WITH GRAPHICAL MODELS
2013
ABSTRACT. Microarray technology allows to collect a large amount of genetic data, such as gene expression data. The activity of the genes are coordinate by a complex network that regulates their expressions controlling common functions, such as the formation of a transcriptional complex or the availability of a signalling pathway. Understanding this organization is crucial to explain normal cell physiology as well as to analyse complex pathological phenotypes. Graphical models are a class of statistical models that can be used to infer gene regulatory networks. In this paper, we examine a class of graphical models: the strongly decomposable graphical models for mixed variables. Among oth- e…
Model uncertainty and variable selection: an application to the modelization of FDI determinants in Europe
2019
Las últimas décadas han visto un interés cada vez mayor en la IED, y un debate creciente sobre su modelización en términos de las variables consideradas como sus determinantes, la especificación del modelo y los métodos de estimación del modelo de gravedad de la IED. Esto se debe a la incertidumbre que rodea tanto las teorías como los enfoques empíricos de la IED. Esta Tesis doctoral tiene como objetivo contribuir a la literatura mediante la investigación de las fuerzas impulsoras de las actividades de las EMNs hacia y desde los países europeos, tanto a nivel regional como nacional, abordando los problemas de selección de variables e incertidumbre del modelo que se enfrentan al modelizar la…
From the forest to the plate – Hemicelluloses, galactoglucomannan, glucuronoxylan, and phenolic-rich extracts from unconventional sources as function…
2021
This study aimed to characterise pressurised hot water (PHW) extracts from nonconventional sources of functional carbohydrates and phenolic compounds in terms of antioxidant capacity, antiviral activity, toxicity, and human erythrocytes’ protection antidiabetic potential. PHW extracts of Norway spruce bark (E1 + E2) and Birch sawdust (E3 + E4) contained mostly galactoglucomannan and glucuronoxylan. In contrast, samples E5 to E9 PHW extracted from Norway spruce, and Scots pine bark are rich sources of phenolic compounds. Overall, phenolic-rich extracts presented the highest inhibition of α-amylase and α-glucosidase and protection against stable non-enveloped enteroviruses. Additionally, all …
Modeling cost-effectiveness and health gains of a âuniversalâ versus âprioritizedâ hepatitis C virus treatment policy in a real-life cohort
2017
We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virusâinfected patients: policy 1, âuniversal,â treat all patients, regardless of fibrosis stage; policy 2, treat only âprioritizedâ patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virusâinfected patients in care). Specifically, 8,125 patients naive to DAA treatment, without clinical, sociodemographic, or insurance restrictions, were us…
Modeling the hydrological and mechanical effect of roots in shallow landslide analysis
2015
The additional cohesion exercised by vegetation roots (cr) provides an important contribution to the slope stability. This study proposes a methodology for estimating the cr term in a hillslope landslide analysis within a coupled ecohydrological-stability model. The coupled model simulates the spatial distribution and temporal dynamics of the Factor of Safety (FS) as a function of soil moisture dynamics, by taking into account the hydrological effects of vegetation through the root water uptaking. The additional mechanical root cohesion is estimated in a Fiber Bundle Model framework that allows for the evaluation of the root strength as a function of stress-strain relationships of populatio…
Hydrological and mechanical effects of roots in shallow landslide analysis: A physically-based approach
2015
This study provides the first insights of a methodology for estimating the additional cohesion exercised by vegetation roots in a hillslope landslide analysis within a coupled ecohydrological-stability model. The existing coupled system is able to simulate the spatial distribution and temporal dynamics of Factor of Safety (FS) as a function of soil moisture dynamics. The model takes into account the hydrological effects of vegetation which, through the root water uptaking, contributes in reducing the soil water content and, thus, in increasing the slope stability. The additional mechanical root cohesion is estimated in a Fiber Bundle Model (FBM) framework that allows for the evaluation of t…
Il dilemma tra amore e onore. Reciprocità e modelli etici in Catullo 76 e in Properzio (Elegie 2,23; 2,24A-B-C-)
2018
Poem 76 is probably the most significant text, among Catullan compositions, for investigating the issues of reciprocity-in-love and honour, which dispose the poet’s world. This paper aims to focus the debate between "benefacta" and "gratia", in comparison with some Propertian elegies that seem to propose very different solutions to the same ethical dispute, whether honour is better than love, or not.
Experiments in Artificial Theory of Mind: From Safety to Story-Telling
2018
Theory of mind is the term given by philosophers and psychologists for the ability to form a predictive model of self and others. In this paper we focus on synthetic models of theory of mind. We contend firstly that such models—especially when tested experimentally—can provide useful insights into cognition, and secondly that artificial theory of mind can provide intelligent robots with powerful new capabilities, in particular social intelligence for human-robot interaction. This paper advances the hypothesis that simulation-based internal models offer a powerful and realisable, theory-driven basis for artificial theory of mind. Proposed as a computational model of the simulation theory of …
The formation, properties and impact of secondary organic aerosol: Current and emerging issues
2009
Hallquist, M. Wenger, J. C. Baltensperger, U. Rudich, Y. Simpson, D. Claeys, M. Dommen, J. Donahue, N. M. George, C. Goldstein, A. H. Hamilton, J. F. Herrmann, H. Hoffmann, T. Iinuma, Y. Jang, M. Jenkin, M. E. Jimenez, J. L. Kiendler-Scharr, A. Maenhaut, W. McFiggans, G. Mentel, Th. F. Monod, A. Prevot, A. S. H. Seinfeld, J. H. Surratt, J. D. Szmigielski, R. Wildt, J.; Secondary organic aerosol (SOA) accounts for a significant fraction of ambient tropospheric aerosol and a detailed knowledge of the formation, properties and transformation of SOA is therefore required to evaluate its impact on atmospheric processes, climate and human health. The chemical and physical processes associated wit…
X-ray flare modeling in the single giant HR 9024
2005
We analyze a Chandra-HETGS observation of the single G-type giant HR 9024. The high flux allows us to examine spectral line and continuum diagnostics at high temporal resolution, to derive plasma parameters (thermal distribution, abundances, temperature, ...). A time-dependent 1D hydrodynamic loop model with semi-length 10$^{12}$cm ($\sim R_{\star}$), and impulsive footpoint heating triggering the flare, satisfactorily reproduces the observed evolution of temperature and emission measure, derived from the analysis of the strong continuum emission. The observed characteristics of the flare appear to be common features in very large flares in active stars (also pre-main sequence stars), possi…