Search results for " Modulation"
showing 10 items of 496 documents
Temporal coherence in mirrorless optical parametric oscillators
2012
International audience; One of the unique features of mirrorless optical parametric oscillators based on counterpropagating three-wave interactions is the narrow spectral width of the wave generated in the backward direction. In this work, we in- vestigate experimentally and numerically the influence that a strong phase modulation in the pump has on the spectral bandwidths of the parametric waves and on the efficiency of the nonlinear interaction. The effects of group-velocity mismatch and group-velocity dispersion are elucidated. In particular, it is shown that the substan- tial increase in temporal coherence of the backward-generated wave can be obtained even for pumping with a temporally…
Complex rogue wave in the fiber optics
2016
This manuscript presents the generation of complex rogue waves related to nonlinear instabilities occurring through the propagation of light in standard optical fibers. Linear and nonlinear physical phenomena involved are first listed, in particular some of them by analogy with the field of hydrodynamics. The different forms of rogue waves induced by the modulation instability process are then presented. They are also known as "breathers", and they are obtained by solving the nonlinear Schrödinger equation. From these exact solutions, various experimental systems were designed by means of numerical simulations based on two rogue-wave excitation methods. The first one is an exact generation …
Design rules for nonlinear spectral compression in optical fibers
2016
International audience; We present comprehensive design rules to optimize the process of spectral compression arising from nonlinear pulse propagation in an optical fiber. Extensive numerical simulations are used to predict the performance characteristics of the process as well as to identify the optimal operational conditions within the space of system parameters. It is shown that the group-velocity dispersion of the fiber is not detrimental and, in fact, helps achieve optimum compression. We also demonstrate that near-transform-limited rectangular and parabolic pulses can be generated in the region of optimum compression.
Photo-thermal modulation of surface plasmon polariton propagation at telecommunication wavelengths
2013
International audience; We report on photo-thermal modulation of thin film surface plasmon polaritons (SPP) excited at telecom wavelengths and traveling at a gold/air interface. By operating a modulated continuous-wave or a Q-switched nanosecond pump laser, we investigate the photo-thermally induced modulation of SPP propagation mediated by the temperature-dependent ohmic losses in the gold film. We use a fiber-to-fiber characterization set-up to measure accurately the modulation depth of the SPP signal under photo-thermal excitation. On the basis of these measurements, we extract the thermo-plasmonic coefficient of the SPP mode defined as the temperature derivative of the SPP damping const…
Pulse doubling and wavelength conversion through triangular nonlinear pulse reshaping
2011
International audience; We present a proof of principle experiment demonstrating the benefits of using a triangular temporal profile in the context of copying and wavelength conversion of telecommunication signals. Generated by passive nonlinear reshaping in a set of two carefully chosen fibres, the triangular shape enables efficient temporal and spectral doubling of the signals through self-phase modulation.
LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.
2012
International audience; Cholesterol is a fundamental molecule for life. Located in the cell membrane, this sterol participates to the cell signaling of growth factors. Inside the cell it can be converted in hormones such as androgens or modulate the immune response. Such important functions could not be solely dependent of external supply by diet hence de novo synthesis could occur from acetate in almost all mammalian cells. If a deficiency in cholesterol sourcing leads to development troubles, overstocking has been associated to various diseases such as atherosclerosis and cancers. Cholesterol homeostasis should thus be tightly regulated at the uptake, de novo synthesis, storage and export…
Phase-Noise and Amplitude-Noise Measurement of DACs and DDSs
2019
This article proposes a method for the measurement of Phase Noise (PN, or PM noise) and Amplitude Noise (AN, or AM noise) of Digital-to-Analog Converters (DAC) and Direct Digital Synthesizers (DDS) based on modulation-index amplification. The carrier is first reduced by a controlled amount (30-40 dB) by adding a reference signal of nearly equal amplitude and opposite in phase. Then, residual carrier and noise sidebands are amplified and sent to a conventional PN analyzer. The main virtues of our method are: (i) the noise specs of the PN analyzer are relaxed by a factor equal to the carrier suppression ratio; and, (ii) the capability to measure the AN using a PN analyzer, with no need for th…
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
2021
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ribonuclear foci. Depletion of this protein is a primary contributor to disease symptoms such as muscle weakness and atrophy and myotonia, yet upregulation of endogenous MBNL1 levels may compensate for this sequestration. Having previously demonstrated that antisense oligonucleotides against miR-218 boost MBNL1 expression and rescue phenotypes in disease models, here we provide preclinical characterization of an antagomiR-218 molecule using the HSALR mouse model and patient-d…
Conditioned Pain Modulation Is Not Impaired in Individuals with Frozen Shoulder: A Case-Control Study
2021
Frozen shoulder (FS) is a poorly understood condition resulting in substantial shoulder pain and mobility deficits. The mechanisms behind FS are not yet fully understood, but, similar to other persistent pain states, central pain mechanisms may contribute to ongoing symptoms in this population. The objective of this research was to investigate conditioned pain modulation (CPM) in people with FS compared with pain-free individuals. A total of 64 individuals with FS and 64 healthy volunteers participated in this cross-sectional study. CPM was assessed by using the pressure pain threshold (PPT) and an occlusion cuff (tourniquet test) as the test and conditioning stimulus, respectively. The abs…
Autophagy
2012
Klionsky, Daniel J. et al.