Search results for " Monitoring"
showing 10 items of 3129 documents
Gas emissions and crustal deformation from the Krýsuvík high temperature geothermal system, Iceland
2020
Abstract The Krýsuvik volcanic system is located on the oblique spreading Reykjanes Peninsula, SW Iceland. Since early 2009 the region has been undergoing episodes of localized ground uplift and subsidence. From April–November 2013, we operated near-real time monitoring of gas emissions in Krýsuvik, using a Multi-component Gas Analyzer System (Multi-GAS), collecting data on gas composition from a fumarole (H2O, CO2, SO2, H2S). The dataset in this study, comprises a near-continuous gas composition time series, the quantification of diffuse CO2 gas flux, analytical results for direct samples of dry gas, seismic records, and GPS data. Gas emissions from the Krýsuvik geothermal system were exam…
Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients
2021
Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…
Voriconazole and the liver.
2015
Voriconazole is an azole useful for the prophylaxis and the treatment of aspergillosis and other fungal infections in immunosuppressed subjects, as those found in aplasia after aggressive polychemotherapy treatments, after hematopoietic stem cell, liver or lung transplantation. Its administration in therapeutic doses lead to extremely varied serum levels from patient to patient and even to the same patient. The explanations are varied: nonlinear pharmacokinetics, certain patient-related factors, including genetic polymorphisms in the cytochrome P450 2C19 gene, the kidney and liver function, simultaneous administration with other drugs metabolised by the same cytochrome. It is recommended to…
Spatial aggregation and resampling expansion of big surveys: An analysis of wage inequality
2020
Income inequality is becoming a growing concern, worldwide, with wage inequality being the root cause of its recent escalation. With the aim of adding to the knowledge on this subject, this paper focuses on the spatial dimension of the problem, an aspect which has received less attention in the literature. We identify the determinants of inequality in wage distribution in Spain at a provincial level using the microdata of the Structure of Earnings Survey (N = 216,769) and estimate their impact from a spatial perspective. Spatial computation of wage concentrations, however, reduces the sample size to just 52 observations, leading to model challenges. To overcome this problem, we adopt a supe…
Environmental Monitoring of Cosmetic Ingredients
2018
Abstract Since the late 1990s there has been an increasing concern regarding the release and accumulation of cosmetic ingredients in the environment. These compounds reach the aquatic environment by direct sources, such as bathing activities, but also by indirect sources due to industrial activities, showering, domestic washing, etc., through wastewater treatment plants at which they are not completely removed. As a result, studies have shown that cosmetic ingredients can be found not only in the water phase but also in sediments, soils and living organisms, thus affecting the flora and fauna of the aquatic environment. In this chapter, the fundamental principles of sample preparation metho…
A practical and user-friendly toxicity classification system with microbiotests for natural waters and wastewaters
2003
Various types of toxicity classification systems have been elaborated by scientists in different countries, with the aim of attributing a hazard score to polluted environments or toxic wastewaters or of ranking them in accordance with increasing levels of toxicity. All these systems are based on batteries of standard acute toxicity tests (several of them including chronic assays as well) and are therefore dependent on the culturing and maintenance of live stocks of test organisms. Most systems require performance of the bioassays on dilution series of the original samples, for subsequent calculation of L(E)C50 or threshold toxicity values. Given the complexity and costs of these toxicity me…
Greening the wastes
2019
Problems associated with analytical waste toxicity and waste treatment are reviewed in the frame of the water treatment, being collected a series of models, from the big-scale treatment of waste waters and adapted to the effluents generated during sample analysis. In fact to move from wastes to clean or no-contaminant wastes is a way from greening those methods in which any sample treatment and the use of reagents and solvents cannot be avoided. The last contributions in the field have been taken into account in this study and future trends have been proposed.
Manure as a potential source of renewable energy: The behaviour and characterisation of biofuels generated from three animal manure types when subjec…
2020
Regions with high livestock density lack sufficient land on which to apply manure without exceeding the legal limits set by the European Union Directives. The lack of manure processing alternatives aggravates the situation, especially in the case of islands. Consequently, manure becomes a liability rather than an asset. Results indicate that pyrolysis is an option for manure processing. However, a significant limitation is the moisture content of the starting material, that could compromise the process efficiency. Yields of biogas, bio-oil and biochar, all of which have a potential use as biofuels, are particular to animal type and manure handling system. The conversion of manure to biofuel…
Torrefied versus conventional pellet production – A comparative study on energy and emission balance based on pilot-plant data and EU sustainability …
2015
Abstract Torrefaction is an emerging technology which enables greater co-firing rates of biomass with coal. To date however there has been a lack of real production data from pilot-scale torrefaction plants. Without such data any environmental benefits of torrefied pellet production are difficult to quantify. In this study data on consumable inputs from a semi-industrial torrefaction plant and the physical properties of produced pellets are used to analyse energy input and air emissions of torrefied pellet production and product transport. EU sustainability criteria are used to compare CO2-equivalent emissions from torrefied and conventional pellet production starting from harvesting of log…
Application of Wastewater-Based Epidemiology for Tracking Human Exposure to Deoxynivalenol and Enniatins
2022
Wastewater-based epidemiology (WBE) is a promising biomonitoring approach with the potential to provide direct information on human intake and exposure to food contaminants and environmental chemicals. The aim of this study was to apply WBE while employing the normalization method for exploring human exposure to selected mycotoxins according to population biomarker 5-hydroxyindoleacetic acid (5-HIAA). This type of normalization technique has been previously used to detect various other compounds. However, to the best of our knowledge, this is the first study tracking human exposure to mycotoxins. A sensitive analytical methodology was developed to achieve reliable quantification of deoxyniv…