Search results for " Movement"

A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

2015

AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…

Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.

2003

E-selectin mediated cell-cell adhesion plays an important role in inflammatory processes and extravasation of tumor cells. Tumor necrosis factor-alpha (TNF-alpha) induces E-selectin gene and protein expression in primary human endothelial cells (HUVEC) and in an endothelial cell line (EA.hy-926). As shown by ELISA and FACS analyses, HMG-CoA reductase inhibitors (e.g., lovastatin) impair the TNF-alpha stimulated increase in E-selectin protein expression. Similar results were obtained for E-selectin mRNA expression and promoter activity, indicating that the effect of lovastatin is based on inhibition of gene expression. The effective inhibitory concentration of lovastatin was in a physiologic…

LAW AND SOCIAL CHANGE: RIGHT TO A NAME, PERSONAL IDENTITY AND PRIVATE LIFE IN CONTEXT

2014

The name is the key to identify a single individual and to link a person to her family, as well as the primary interface in the relationship between a person and the community he or she lives in. This study claims that private life and private autonomy are becoming interpretative arguments and vehicles to ensure that law would be able to follow – and sometimes to chase – social changes in personal and family life, in finding new rules to regulate the relationship between the individual, the family and public authorities or between a private individual and the community she interfaces with.1 Judicial interpretative activity often reveals legislative shortcomings. In particular, the judiciary…

Ruch pokojowy w RFN (Friedensbewegung) w pierwszej połowie lat osiemdziesiątych XX wieku

2017

W latach 80. XX wieku ruch pokojowy mobilizujący setki tysięcy osób w protestach przeciwko podwójnej uchwale NATO z grudnia 1979 r. był istotnym elementem zachodnioniemieckiej sceny politycznej. Wpływał na układ sił i konflikty wewnętrzne w socjaldemokracji niemieckiej (SPD), będąc największym oponentem polityki prowadzonej przez rząd kanclerza Helmuta Schmidta, przyczynił się do powstania Partii Zielonych, a jego działania doprowadziły do zaistnienia polemiki w związkach zawodowych i były bodźcem do dyskusji etycznych i religijnych w Kościele katolickim i protestanckim w RFN. Stał się również przedmiotem wielu kontrowersji oraz symbolem aktywności i siły społecznej.

Coping with rural transition in northern Thailand : an analysis of rural economic diversification and social movements' response

2006

"Laulu syömmet aukaisee" : kokonaisvaltainen laulunopetus musiikkiliikunnan avulla

2018

The subject of this research is a holistic approach to singing education using body movements. This study was conducted as action research in which the singing pedagogue also worked as a researcher. The aim of this study was to: develop an approach to singing education with body movements, qualitatively investigate how singing with body movements can be used in solo singing education and how pedagogical ideas of Finnish music and movement teacher Inkeri Simola-Isaksson could be adapted to singing education. The data included interviews of the vocal students at the University of Oulu and the vocal students of the Johann Sebastian Bach music school in Vienna, participant journals and research…

Natal Dispersal of First Winter Peregrine Falcons

2017

Quantitative information about natal dispersal is available for many species, usually focused on their long-distance migration. Basic information on non-migrant Peregrine falcons is virtually lacking, despite the amount of scientific data on this species, and the sensitivity of this stage in the Peregrines’ life history. Information on movements is crucial for the definition of young post-fledging areas, the behaviour of floaters and also gives key information about juvenile mortality. Thanks to satellite telemetry, we were able to provide data about the destiny, movement and habitat use during both the phase of post-fledging dependence by parents (PFDP) and the dispersal period of 14 Peregr…

Apparenti disegni eretici

2022

Il vocabolario Zingarelli, tra i significati del termine ‘eresia’, riporta: “nelle religioni fondate su una dogma- tica universalmente o ufficialmente riconosciuta, dottrina basata su interpretazioni personali in contra- sto con la tradizione” oppure “opinione erronea o contrastante con quelle più comunemente seguite” e, in ultimo “discordia”. È eretico quindi colui che ha scelto, chi sostiene principi contrari ad una ideolo- gia. Uno degli aspetti dell’architettura, quello probabilmente più confortante, è il disegno inteso nel dop- pio significato di intenzione e di rappresentazione di qualcosa di reale o immaginato; gli schizzi, nei loro tratti essenziali, comunicano un pensiero, un’i…

Revisiting the cross‐sectional and prospective association of physical activity with body composition and physical fitness in preschoolers: A composi…

2022

Background Information is limited for the benefits of physical activity (PA) in preschoolers. Previous research using accelerometer-assessed PA may be affected for multicollinearity issues. Objectives This study investigated the cross-sectional and prospective associations of sedentary behaviour (SB) and PA with body composition and physical fitness using compositional data analysis. Methods Baseline PA and SB were collected in 4-year-old (n = 315) using wrist-worn GT3X+ during seven 24 h-periods. Body composition (air-displacement plethysmography) and physical fitness (PREFIT test battery) were assessed at baseline and at the 12-month follow-up. Results Increasing vigorous PA at expenses o…

Huhut, unet, sodomiitit, moraalinvartijat, elämäkerrat, puhuttelusanat ja ammattinimikkeet

2022

Kirja Huhut, unet, sodomiitit, moraalinvartijat, elämäkerrat,puhuttelusanat ja ammattinimikkeet koostuu teoreettisista artikkeleista ja tutkielmista, joiden käsittelemät aikakaudet ulottuvat keskiajalta aina itsenäisyyden murrosvaiheisiin. Teemaa lähestytään yksilön ja yhteiskunnan välisten suhteiden ilmentymänä. Artlkkelit edustavat kunkin kirjoittajan tutkimussuuntausta. Näin ollen kyseessä on teos, jossa esitetään myös uusimman historiantutkimuksen tuloksia. Kirjoittajat ovat historiantutkijoita ja Jyväskylän maakunta-arkiston henkilökuntaa.