Search results for " Neoplasia"

showing 10 items of 98 documents

Medullary Thyroid Carcinoma With Exon 2 p.L56M RET Variant: Clinical Particular Features in Two Patients

2018

RET (REarranged during Transfection) proto-oncogene variants are essential for the development of familial and sporadic forms of medullary thyroid carcinoma (MTC). The most frequent variants are usually located in exons 10, 11, and 13 through 16 of the RET gene. We report two cases of apparently sporadic MTC associated with the variant in exon 2 of RET gene. Patient 1, a 62-year old man who had undergone adrenalectomy for a 5 cm pheochromocytoma, was screened for type 2 multiple endocrine neoplasia (MEN 2) which showed elevated basal and post-intravenous calcium gluconate calcitonin levels. A fine needle aspiration biopsy (FNAB) confirmed the suspicion of MTC. The patient underwent total th…

Pathologymedicine.medical_specialtyendocrine systemMedullary cavityendocrine system diseasesEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismCase ReportL56M; Medullary thyroid carcinoma; MEN2; Pheochromocytoma; RET; Endocrinology Diabetes and Metabolismlcsh:Diseases of the endocrine glands. Clinical endocrinologyThyroid carcinomaPheochromocytoma03 medical and health sciences0302 clinical medicineEndocrinologymedullary thyroid carcinomaBiopsymedicineMultiple endocrine neoplasialcsh:RC648-665medicine.diagnostic_testbusiness.industrySettore MED/13 - ENDOCRINOLOGIAHyperplasiamedicine.diseasepheochromocytomaDiabetes and MetabolismFine-needle aspirationMEN2Calcitonin030220 oncology & carcinogenesisbusinessRETL56MFrontiers in Endocrinology
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Cervical intraepithelial neoplasia (CIN) in pregnancy: The state of the art

2014

Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both in terms of diagnostic accuracy, treatment options and risk of obstetrical complications. For these reasons, lack of uniformity in diagnosis and management is still commonly observed and the need for evidence-based clarifications is strongly required. Consistently with the literature evidences and accordingly with international guidelines, this review aim to overview the most significant aspects of the issue and…

PregnancyRisk FactorsRisk FactorHumansUterine Cervical NeoplasmsFemaleCervical Intraepithelial NeoplasiaUterine Cervical DysplasiaHuman
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Edad, creencias de salud y asistencia a un programa de cribado mamográfico en la comunidad valenciana

2004

Yolanda Andreu Vaillo, Mª José Galdón Garrido, Estrella Durá Ferrandis, Stephanie Carretero Gómez (yolanda.andreu@uv.es) La edad influye significativamente en las creencias de salud relacionadas con la asistencia a programas de cribado mamográfico. El objetivo de este trabajo es analizar las creencias y actitudes hacia el cáncer de mama asociadas a la asistencia a un programa de cribado en diferentes grupos de edad.Métodos: Utilizando un diseño transversal se comparan las creencias de salud de un grupo de mujeres que acuden a un programa de cribado con las de las mujeres que no lo hacen, considerando tres intervalos de edad: menores de 50 años (N=279), 50-60 años (N=463), mayores de 60 (N=2…

PrevenciónUNESCO::CIENCIAS MÉDICAS ::Salud públicalcsh:Public aspects of medicinelcsh:Rlcsh:MedicineDistribución por edad:CIENCIAS MÉDICAS ::Salud pública [UNESCO]lcsh:RA1-1270NeoplasiasDistribución por edad; Prevención; Neoplasias
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Atypical epithelial hyperplasia of the breast: state of the art.

2016

International audience; Introduction: Atypical epithelial hyperplasia (AEH) of the breast is considered benign histological lesions with breast cancer risk. This review focuses on clinical signification and management of AEH that remains controversial. Areas covered: A review of published studies was performed using medline database. In this review, we fully describe the current evidence available. In particular, we describe 1) data from immunohistochemistry and molecular studies that suggest AEH is a precursor of breast cancer; 2) epidemiological studies demonstrate low rate of breast cancer in women with AEH; 3) surgical excision is necessary after diagnosis of AEH, such as lobular carcin…

RiskPathologymedicine.medical_specialtysurgical excisionBiopsyLobular carcinoma[SDV.CAN]Life Sciences [q-bio]/CancerBreast NeoplasmsAtypical ductal hyperplasiacore needle biopsy030218 nuclear medicine & medical imagingatypical lobular hyperplasia03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerBiopsyAtypiaMedicineHumansPharmacology (medical)Epithelial hyperplasiaBreastskin and connective tissue diseaseslobular carcinoma in situHyperplasiamedicine.diagnostic_testbusiness.industryHyperplasiamedicine.diseaseImmunohistochemistry3. Good healthOncologycolumnar cell lesions with atypia030220 oncology & carcinogenesisImmunohistochemistryFemalebusinesslobular neoplasiaPrecancerous ConditionsLobular NeoplasiaExpert review of anticancer therapy
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Immunohistochemical expression of CB1 cannabinoid receptor in the laryngeal-tracheal tract in humans suffering from laryngeal neoplasia

2009

Settore BIO/17 - IstologiaSettore MED/31 - OtorinolaringoiatriaCB1 cannabinoid laryngeal neoplasia
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Aneurisma dell'aorta addominale e patologia neoplastica associata

2012

Settore MED/22 - Chirurgia VascolareAneurisma aorta chirurgia EVAR neoplasia
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L’ATTIVITA’ FISICA NEI BAMBINI CON PREGRESSA NEOPLASIA: PREVENZIONE DEL RISCHIO NEUROMUSCOLARE E MUSCOLO-SCHELETRICO

2012

Settore MED/38 - Pediatria Generale E SpecialisticaSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveATTIVITA’ FISICA NEOPLASIA RISCHIO NEUROMUSCOLARE E MUSCOLO-SCHELETRICO
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PROGETTO PILOTA PER LO SVOLGIMENTO DELL’ATTIVITA’ MOTORIA IN BAMBINI E ADOLESCENTI CON PREGRESSA NEOPLASIA

2012

Settore MED/38 - Pediatria Generale E SpecialisticaSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveATTIVITA’ MOTORIA ETA' EVOLUTIVA NEOPLASIA
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PREOPERATIVE ASSESSMENT OF RECTAL CANCER: AN ACCURATE MRI PROTOCOL A RADIOLOGICAL TEMPLATE

2015

Learning objectives Background Findings and procedure details Conclusion Personal information References

Staginggenetic structuresGastrointestinal tractOncologyNeoplasiaeducationAbdomenEducation and trainingMRGastrointestinal tract Abdomen Oncology MR Staging Education and training Neoplasia
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