Search results for " Neuromuscular"
showing 4 items of 114 documents
Mental fatigue induced by prolonged self-regulation does not exacerbate central fatigue during subsequent whole-body endurance exercise
2015
International audience; It has been shown that the mental fatigue induced by prolonged self-regulation increases perception of effort and reduces performance during subsequent endurance exercise. However, the physiological mechanisms underlying these negative effects of mental fatigue are unclear. The primary aim of this study was to test the hypothesis that mental fatigue exacerbates central fatigue induced by whole-body endurance exercise. Twelve subjects performed 30 min of either an incongruent Stroop task to induce a condition of mental fatigue or a congruent Stroop task (control condition) in a random and counterbalanced order. Both cognitive tasks (CTs) were followed by a whole-body …
Metalloproteinases and Tissue Inhibitors in Generalized Myasthenia Gravis. A Preliminary Study
2022
Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have recently been proposed as promising biomarkers in different immune-mediated disorders. We evaluated the plasma levels of MMP-9 and MMP-2 and their tissue inhibitors TIMP-1 and TIMP-2 in a patients’ cohort with generalized myasthenia gravis (MG). Methods: Plasma concentrations of MMP-9, MMP-2, TIMP-1 and TIMP-2 were evaluated in 14 patients with generalized MG and 13 age- and sex-matched healthy controls. The severity of disease was assessed by the modified Osserman classification. Results: Compared to the healthy subjects, MG patients had increased plasma concentrations of MMP-9, but redu…
Acción del sugamadex y de los bloqueantes neromusculares: rocuronio y vecuronio en neuronas en cultivo primario
2017
INTRODUCCIÓN: El ROCURONIO y VECURONIO son los relajantes musculares no despolarizantes BNMNP más usados en la práctica clínica. El SUGAMADEX es el fármaco utilizado como reversor de la relajación muscular producida por los bloqueantes neuromusculares citados. En el presente trabajo analizamos los efectos del SUGAMADEX, la implicación del colesterol en los mismos y el posible papel protector del ROCURONIO y VECURONIO en cultivos primarios de neuronas de rata. HIPÓTESIS: Debido a la introducción paulatina del fármaco SUGAMADEX en la clínica y de los bloqueantes neuromusculares tipo ROCURONIO y VECURONIO, nos planteamos si estos fármacos o su combinación podrían ocasionar muerte neuronal en c…