Search results for " Node"
showing 10 items of 602 documents
Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review
2019
Background Vaccine adjuvants are compounds that significantly enhance/prolong the immune response to a co-administered antigen. The limitations of the use of aluminium salts that are unable to elicite cell responses against intracellular pathogens such as those causing malaria, tuberculosis, or AIDS, have driven the development of new alternative adjuvants such as QS-21, a triterpene saponin purified from Quillaja saponaria. Purpose The aim of this review is to attempt to clarify the mechanism of action of QS-21 through either receptors or signaling pathways in vitro and in vivo with special emphasis on the co-administration with other immunostimulants in new adjuvant formulations, called a…
Preclinical immunomodulation by the probiotic Bifidobacterium breve M-16V in early life
2016
This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immu…
Interleukin 4 suppresses primary interferon gamma response by T cells immunized in vivo and cultured in vitro with interleukin 2.
1996
This paper describes a novel primary in vivo/in vitro culture system which allows analysis of the effect of IL-4 added to culture 1 day after immunization on the production of IFN-gamma. Mice are immunized epicutaneously with picryl chloride (TNP) and draining lymph node cells were harvested 1 day later. These cells (1 day lymph node cells), when cultured in vitro for 3 days in the presence of IL-2, either continuously or as a pulse, give an IFN-gamma response on reexposure to antigen 3 days later. This production of IFN-gamma is both antigen-specific and genetically (MHC)-restricted and is due to both CD8+ and CD4+ T cells. However, if 1 day lymph node cells are cultured with both IL-2 and…
Intestinal Involvement in Kawasaki Disease
2018
Objectives To describe a case of Kawasaki disease with intestinal involvement and to analyze other published reports to define clinical characteristics, diagnostic issues, and therapeutic approaches of gastrointestinal involvement in Kawasaki disease. Study design A computerized search without language restriction was conducted using PubMed and SCOPUS. An article was considered eligible for inclusion in the systematic review if it reported data on patient(s) with intestinal involvement in Kawasaki disease. Our case was also included in the analysis. Results Thirty-three articles reporting 48 cases of Kawasaki disease with intestinal involvement were considered. Fever, abdominal pain, and vo…
A backward sweep method for power flow solution in distribution networks
2010
Abstract A methodology for the analysis of radial or weakly meshed distribution systems supplying voltage dependent loads is here developed. The solution process is iterative and, at each step, loads are simulated by means of impedances. Therefore, at each iteration, it is necessary to solve a network made up only of impedances; for this kind of network, all the voltages and currents can be expressed as linear functions of a single unknown current (in radial systems) or of two unknown currents for each independent mesh (for meshed systems). The methodology has been called “backward” since the unique equation, in case of radial network, and the linear system of equations, in case of meshed n…
Effects and Benefits of Node Sharing Strategies in HPC Batch Systems
2019
Processor manufacturers today scale performance by increasing the number of cores on each CPU. Unfortunately, not all HPC applications can efficiently saturate all cores of a single node, even if they successfully scale to thousands of nodes. For these applications, sharing nodes with other applications can help to stress different resources on the nodes to more efficiently use them. Previous work has shown that the performance impact of node sharing is very application dependent but very little work has studied its effects within batch systems and for complex parallel application mixes. Administrators therefore typically fear the complexity of running a batch system supporting node sharing…
Heat-stable antigen is expressed by murine keratinocytes and delivers costimulatory signals in T-cell activation.
1995
Heat-stable antigen (HSA), expressed by various antigen-presenting cells (APC), has been described as a costimulatory molecule for CD4+ T cells. Recently, we observed that HSA also serves as an important costimulatory molecule on epidermal Langerhans cells (LC). During these studies, low levels of HSA staining were also detected on normal murine keratinocytes (KC). To investigate whether HSA also is involved in T-cell activation by KC, normal murine KC or the spontaneously transformed KC cell-line PAM 212 were treated with PDB or PMA to induce HSA-expression. FACS analyses showed induction of HSA expression on normal murine KC, as well as PAM 212 cells. In functional assays PDB or PMA-treat…
A Multisensor Proposal for Wireless Sensor Networks
2008
Every sensor node in a wireless sensor network (WSN) has a microcontroller, a transmitter/receiver and a sensor. It is able to acquire data from specific point in a real environment and transmit it through the WSN. Sometimes it is useful to gather different type of data from the same place in order to obtain a final result. In the related literature, very few works are about sensing different parameters using a unique sensor. In this paper we propose a Wireless IP multisensor that is able to gather several types of data from the environment and transmit the result of their combination. Our proposal decision has being mainly based on its development costs, its expansion capacity and its flex…
On Applications of Wireless Sensor Networks
2009
Wireless Sensor Networks (WSN) are ad-hoc networks in which small independent sensor nodes have limited energy, computational resources and wireless communication capabilities. Recently, both academia and industry have shown great interest in the area of Wireless Sensor Networks. This paper focuses on the practical applications in commerce and feasible future employment of WSNs. Continued advances of wireless communication technologies have led to the following fields of applications: habitat and environmental monitoring, security of buildings and property, oil and gas installations, mines and tunnels, emergency medical care, military applications. In the near future WSNs will certainly ent…
EP260 Is there still a role for laparoscopic radical hysterectomy? Personalizing surgical approach in early stage cervical cancer
2019
Introduction/Background To compare survival outcomes of laparoscopic and open surgery for radical hysterectomy (RH) among patients with early-stage cervical cancer (CC) and to identify which subgroups may benefit from one approach rather than the other. Methodology 237 and 303 consecutive patients, with clinical FIGO stage from IA1 with lymph vascular space involvement to IB1/IIA1 CC underwent open and laparoscopic RH respectively in 3 Italian Institutions. Differences in terms of progression-free survival (PFS) between the two surgical approaches were tested in the entire population and in different patient‘s subgroups. Results Median follow up was 34 months. Open and laparoscopy procedure…