Search results for " Order"

Multiplicity results for fourth order two-point boundary value problems with asymmetric nonlinearities

1998

Vācijas pašaizsargājošās demokrātijas modeļa piemērošanas iespējas Latvijā

2017

Maģistra darbs “Vācijas pašaizsargājošās demokrātijas modeļa piemērošanas iespējas Latvijā” ir izstrādāts ar mērķi analizēt demokrātijas aizsardzības veidus un apdraudējuma pakāpi, kā arī sabiedrības attieksmi pret demokrātijas pašaizsargāšanās modeli Latvijā. Pētījuma iecere saistāma apstāklī, ka demokrātiskās iekārtas stiprināšana un nodrošināšana pret iespējamu apdraudējumu ir ar pieaugošu aktualitāti Latvijas politiskajā procesā un sabiedriskajā domā. Pētījumā analizēts pašaizsargājošās demokrātijas teorētiskais modelis, tā ieviešana un attīstība Vācijā, kā arī analizēti demokrātijas aizsardzības veidi Latvijas Republikas likumdošanā un politiskajā procesā, tos aplūkojot kontekstā ar ie…

Hospital Reform in Palermo

2023

A partire dal XV secolo, l'ospedale cessa di essere un riflesso della carità cristiana e diventa un veicolo per la gestione del bene comune. In precedenza, la diffusione della spiritualità influenzata dagli Ordini mendicanti aveva stimolato nuove forme di pietà e opere di carità più ampie, tra cui le visite ai malati, la gestione degli ospedali e la distribuzione di cibo e vestiario. Il tardo Medioevo vide un un cambiamento radicale. Gli ospedali divennero centri polifunzionali dedicati a vari tipi di cure. In linea con una tendenza osservata in tutta Europa, le principali città siciliane (Messina, Catania, Palermo, Siracusa e Trapani) adattarono i propri sistemi ospedalieri alle esigenze d…

Peasants and the Political Culture in Norway (c. 1400–1700)

2016

This chapter looks at the major confrontations between the state and peasants in Norway during the period 1400–1700. These have variously been described as rebellions, riots and insurrections. Indeed, one could argue that none of these were full-scale revolts as such, if by that we mean a massive threat to the regime and social order. The peasants and their leaders would never declare that they were seeking to abolish the regime or attack the king nor that they intended to implement a new social or political order. In most cases, they would address oral or written protests or sabotage the collection of new taxes or other burdens that the state had imposed. Their protests would primarily be …

Process specification and verification

1996

Graph grammars provide a very convenient specification tool for distributed systems of processes. This paper addresses the problem how properties of such specifications can be proven. It shows a connection between algebraic graph rewrite rules and temporal (trace) logic via the graph expressions of [2]. Statements concerning the global behavior can be checked by local reasoning.

La Corte costituzionale apre al divieto di retroattività del novum penitenziario in malam partem.

2020

With a courageous judgment, the Constitutional Court extends the application scope of art. 25, par. 2, Cost. in the criminal enforcement sector. Censoring the living law, the Court states the prohibition of the retroactivity of the measures more afflictive introduced by law no. 3 of 2019 to convicts who committed the fact before its entry into force. The Author, after dwelling on the new paradigm of "European legality", retraces the salient passages of the decision, from which it draws the innovative message of the Judge of the laws.

Germline correction of an epimutation related to Silver-Russell syndrome.

2015

Like genetic mutations, DNA methylation anomalies or epimutations can disrupt gene expression and lead to human diseases. However, unlike genetic mutations, epimutations can in theory be reverted through developmental epigenetic reprograming, which should limit their transmission across generations. Following the request for a parental project of a patient diagnosed with Silver-Russell syndrome (SRS), and the availability of both somatic and spermatozoa DNA from the proband and his father, we had the exceptional opportunity to evaluate the question of inheritance of an epimutation. We provide here for the first time evidence for efficient reversion of a constitutive epimutation in the sperm…

Template-Directed Protein Folding into a Metastable State of Increased Activity

1995

The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman-Birk-type proteinase inhibitor of trypsin and chymotrypsin was selected as a double-headed model protein to facilitate the detection of functional irregularities by the use of functional assays. The parent protein spontaneously folds into a single, fully active and thermodynamically stable state in a redox buffer after reduction/denaturation. By contrast, the properties of a P'1Ser--Pro variant in the trypsin-reactive subdomain differ before an…

Self-assembly of biopolymeric structures below the threshold of random cross-link percolation

1996

Self-assembly of extended structures via cross-linking of individual biomolecules often occurs in solutions at concentrations well below the estimated threshold for random cross-link percolation. This requires solute-solute correlations. Here we study bovine serum albumin. Its unfolding causes the appearance of an instability region of the sol, not observed for native bovine serum albumin. As a consequence, spinodal demixing of the sol is observed. The thermodynamic phase transition corresponding to this demixing is the determinative symmetry-breaking step allowing the subsequent occurrence of (correlated) cross-linking and its progress up to the topological phase transition of gelation. Th…

The test skeletal matrix of the black sea urchin Arbacia lixula

2015

11 pages; International audience; In the field of biomineralization, the past decade has been marked by the increasing use of high throughput techniques, i.e. proteomics, for identifying in one shot the protein content of complex macromolecular mixtures extracted from mineralized tissues. Although crowned with success, this approach has been restricted so far to a limited set of key-organisms, such as the purple sea urchin Strongylocentrotus purpuratus, the pearl oyster or the abalone, leaving in the shadow non-model organisms. As a consequence, it is still unknown to what extent the calcifying repertoire varies, from group to group, at high (phylum, class), median (order, family) or low (g…