Search results for " Outbreak"
showing 10 items of 640 documents
Is large-scale rapid CoV-2 testing a substitute for lockdowns?
2021
Background Various forms of contact restrictions have been adopted in response to the Covid-19 pandemic. Around February 2021, rapid testing appeared as a new policy instrument. Some claim it may serve as a substitute for contact restrictions. We study the strength of this argument by evaluating the effects of a unique policy experiment: In March and April 2021, the city of Tübingen set up a testing scheme while relaxing contact restrictions. Methods We compare case rates in Tübingen county to an appropriately identified control unit. We employ the synthetic control method. We base interpretations of our findings on an extended SEIR model. Findings The experiment led to an increase in the …
The international Ebola response: heroes and bystanders in the chronicle of an epidemic foretold.
2014
Work-life balance during the COVID-19 outbreak: the case of Latvia
2020
This paper aims to shed light on work-life balance in Latvia during the state of emergency The COVID-19 outbreak has led many governments to introduce lockdowns While imposed restrictions may help to contain the spread of the virus, they may also result in substantial damage to population well-being The COVID-19 outbreak in Latvia demonstrates the extent and ways in which socio-demographics factors have determined different patterns of behaviour, attitudes, employment changes and harmonised work and life balance The study describes the chronological development of COVID-19 in the country It describes labour migration to and from Latvia before the COVID-19 outbreak It provides geographical f…
Discrimination of non-infectious SARS-CoV-2 particles from fomites by viability RT-qPCR.
2021
The ongoing coronavirus 2019 (COVID-19) pandemic constitutes a concerning global threat to public health and economy. In the midst of this pandemic scenario, the role of environment-to-human COVID-19 spread is still a matter of debate because mixed results have been reported concerning SARS-CoV-2 stability on high-touch surfaces in real-life scenarios. Up to now, no alternative and accessible procedures for cell culture have been applied to evaluate SARS-CoV-2 infectivity on fomites. Several strategies based on viral capsid integrity have latterly been developed using viability markers to selectively remove false-positive qPCR signals resulting from free nucleic acids and damaged viruses. T…
Organoids of human airways to study infectivity and cytopathy of SARS-CoV-2
2020
Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021
2021
COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95…
The gender gap in the diagnostic-therapeutic journey of the infertile couple
2021
Medical procreation impairs both the biological and psychological lives of couples. However, male and female attitudes to infertility are different and require a different approach during the IVF journey. Thus, the gender impact assessment (GIA) method was used to analyse original studies present in the literature. We found some gender-related differences and, subsequently, possible outcomes of intervention to improve healthy reproduction management and prevent infertility. In particular, it became apparent that there was the need for an in-depth male infertility assessment and a gender-specific follow-up.
Host-directed therapies for COVID-19
2021
Purpose of review Severe acute respiratory syndrome coronavirus-2-induced hyperinflammation is a major cause of death or end-organ dysfunction in COVID-19 patients. We review adjunct host-directed therapies (HDTs) for COVID-19 management. Recent findings The use of umbilical cord-derived mesenchymal stem cells as HDT for COVID-19 has been shown to be safe in phase 1 and 2 trials. Trials of anti-interleukin-6 receptor antibodies show promising mortality benefit in hospitalized COVID-19 patients. Repurposed drugs and monoclonal antibodies targeting specific cytokines acting on different aspects of the pro- and anti-inflammatory cascades are under evaluation. Summary A range of HDTs shows prom…
Molecular mimicry may explain multi-organ damage in COVID-19
2020
International audience
Corona-Komposita und ‚Corona‘-Konzepte in der Medienberichterstattung in Standardsprache und in Leichter Sprache
2021
Abstract First linguistic studies have paid attention to the influence of the current corona pandemic on language use in the German media coverage. They have revealed, amongst other things, that compounds beginning with corona are very productive and frequent. Against this background, the questions arise how frequent these compounds de facto are, what their morphological and graphematic characteristics look like, which second constituents can be observed, which semantic relations between the constituents exist and what their referents are. However, not only people being able to read texts in standard language need information concerning the pandemic; individuals lacking this capacity also n…