Search results for " PATOLOGIA"

Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Rel…

2023

: Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subj…

Longevity hotspot in Sicily. The exploration of a new possible blu zone

We are conducting a survey in some mountainous Sicilian populations, particularly in villages sited in the Palermo province, part of the Madonie Park. To ascertain the true longevity rate, we checked the born and death registers, analyzing about 37,000 newborns between 1881 and 1917 in a sample of five small municipalities located in Madonie. About 1,700 individuals died at the age of 90 years and over, and about one hundred were centenarians. Therefore, the probability to reach 90 and 100 years old was of 4.6% and 0.22% respectively. Accordingly, we observed significant lower mortality rates for all causes of death when compared to those measured in Palermo town. Therefore, the population …

16th IHIW: Immunogenetics of Aging

2013

Ageing is a process characterised by progressive loss of function in multiple different organ systems, such as the nervous, endocrine and immune systems. Current data showing that ageing processes may be associated with alterations in the immune system suggest that some of the genetic determinants of senescence might be polymorphic genes that regulate immune responses. The ‘Immunogenetics of Aging’ programme was a component introduced in the 14th International HLA and Immunogenetics Workshop (IHIWS) and developed further within the 15th and 16th. The aim of this component was to determine the contribution of immune genes to successful ageing and an increased capacity to reach the extreme li…

Cancro e Invecchiamento

2023

Gli studi epidemiologici hanno dimostrato che la mortalità per cancro aumenta con l’età fino al novantesimo anno, in cui raggiunge il plateau e quindi declina (Fig. 61.1). La mortalità per cancro è di circa il 40% dai 50 ai 70 anni e inferiore al 4% nei centenari. Questo non è strano perché è noto che i longevi ritardano o evitano quasi tutte le malattie infiammatorie legate all’età e il can-cro è una malattia in cui la componente infiammatoria gioca un ruolo rilevante........................................

RUOLO DEI "RECETTORI ATIPICI" PER CITOCHINE E CHEMOCHINE, TIR8 E D6, NELLA REGOLAZIONE DELLE RISPOSTE INFIAMMATORIE INDOTTE DA MYCOBACTERIUM TUBERCUL…

2011

Genetic variation in human leukocyte antigen and susceptibility to acute myeloid leukemia.

2015

In this issue of Acta Haematologica, Authors report the association between the Human Major Histocompatibility complex (MHC) HLA-C3 and Acute Myeloid Leukemia (AML) in Korean population, confirming previous studies on association between HLA-C and AML.

Interleukin-6 Is a Promising Marker of COVID-19 in Children: A Case Series of 2 Brothers with Severe COVID-19 Pneumonia.

2022

BACKGROUND To date, Coronavirus disease 2019 (COVID-19) remains a global health concern, with fatalities mostly in older age groups with underlying medical conditions, while children are less likely to manifest severe symptoms. CASE REPORT We describe the clinical cases of 2 brothers admitted to our Children's Hospital for persistent fever and cough during the COVID-19 pandemic. Case 1. A 1.5-year-old boy had fever, expiratory dyspnea, desaturation, oxygen saturation 94-96% with O2, and bilateral hissing and crackling rales. His interleukin-6 level in the acute phase of the disease was 100.41 and at the resolution it was 46.2 pg/ml. Treatment with amoxicillin plus clavulanic acid, methylpre…

Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8+ T Cells

2022

The immune system, smartly and surprisingly, saves the exposure of a particular pathogen in its memory and reacts to the pathogen very rapidly, preventing serious diseases.Immunologists have long been fascinated by understanding the ability to recall and respond faster and more vigorously to a pathogen, known as “memory”.T-cell populations can be better described by using more sophisticated techniques to define phenotype, transcriptional and epigenetic signatures and metabolic pathways (single-cell resolution), which uncovered the heterogeneity of the memory T-compartment. Phenotype, effector functions, maintenance, and metabolic pathways help identify these different subsets. Here, we exam…

Obesità, Microbiota e Aging

2016

Systematic review by meta-analyses on the possible role of TNF-alpha polymorphisms in association with Alzheimer's disease.

2009

It has been hypothesized that polymorphisms of Tumor Necrosis Factor (TNF)-alpha gene affect the risk of developing Alzheimer's disease (AD). However, results of different studies are often inconsistent. Our aim was to investigate by meta-analysis the association of the common polymorphisms comprehensively defining the genetic variability of the TNF-alpha gene with AD risk. Hence, the results being stated are of a meta-analysis across studies, and that this meta-analysis does not invalidate the results of the individual studies previously performed. Seventeen studies that investigated the association between 5 TNF-alpha polymorphisms (-850, -308, -863, -238, and -1031) and AD were retrieved…