Search results for " PD"
showing 10 items of 651 documents
Local vs global motions in protein folding
2013
It is of interest to know whether local fluctuations in a polypeptide chain play any role in the mechanism by which the chain folds to the native structure of a protein. This question is addressed by analyzing folding and non-folding trajectories of a protein; as an example, the analysis is applied to the 37-residue triple β-strand WW domain from the Formin binding protein 28 (FBP28) (PDB ID: 1E0L). Molecular dynamics (MD) trajectories were generated with the coarse-grained united-residue force field, and one- and two-dimensional free-energy landscapes (FELs) along the backbone virtual-bond angle θ and backbone virtual-bond-dihedral angle γ of each residue, and principal components, respect…
TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
2015
Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be elucidated. In this study, we analyzed a set of patient-derived breast cancer stem cell (BCSC) lines. We found that in vitro BCSCs exhibit a higher chemoresistance and migratory potential when compared with differentiated, nontumorigenic, breast cancer cells (dBCCs). By developing an in vivo metastatic model simulating the disease of patients with early BC, we observed that BCSCs…
Effect of Pre-Reduction on the Properties and the Catalytic Activity of Pd/Carbon Catalysts: A Comparison with Pd/Al2O3
2013
The effect of pre-reduction in solution with chemical reagents on the catalytic performance and catalyst properties of Pd/carbon catalysts was systematically investigated with a multitechnique approach. The results are critically discussed in comparison to those recently obtained on analogous Pd/alumina catalysts. It was proved that the Pd phase on the carbon surface is characterized by a high mobility, opposite to what occurs on alumina. As a result, the Pd particles on carbon aggregate together during pre-reduction, with a consequent decrease in available metal surface. Pd particles remain aggregated also in reaction conditions; the decreased Pd dispersion negatively affects the catalyst …
Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells
2022
Abstract Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte-independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells. Experimental Design: PD-1 in NSCLC cells was explored in vitro at baseline, including stem-like pneumospheres, and following treatment with cisplatin both at transcriptional and protein levels. PD-1 signaling and RNA sequencing were assessed. The lymphocyte-independent antitumor activity of aPD-1 was explored in…
1983 mayo. Las elecciones autonómicas y locales. 8 de mayo de 1983. Comunidad Valenciana. Materiales, Publicaciones
2006
Este documento contiene diversos papeles sobre Las elecciones autonómicas y locales. 8 de mayo de 1983 en la Comunidad Valenciana. Programa electoral PSPV-PSOE. Generalitat Valenciana. Manual del candidato. «Por el pueblo». Sondeos de opinión. Instituciones de la Generalitat 1984, etc.
Comparison between various bituminous binders modified with crumb tyre rubber
2009
The aim of this paper is to show how the rheology, the performance and the storage stability of different bituminous binders, obtained from two bitumens with different asphaltenes content, change their properties when they are modified with recycled tyre crumb rubber. Physical, chemical and performance characterisation followed by rheological and storage stability analyses have been undertaken as the basis for the comparison. The results of the investigation indicate that bitumen with lower asphaltenes content is more influenced by the modification with the rubber. However, the modification of the bitumen with the higher asphaltenes content gives a binder with better performance and storage…
Dimension reduction for $-Delta_1$
2012
A 3D-2D dimension reduction for $-\Delta_1$ is obtained. A power law approximation from $-\Delta_p$ as $p \to 1$ in terms of $\Gamma$- convergence, duality and asymptotics for least gradient functions has also been provided.
Summary of Week VII
2018
International audience; Week VII of the INT program 2018 “Probing Nucleons and Nuclei in High Energy Collisions” was dedicated to topics at the interface of the electron-ion collider (EIC), heavy ion and proton-nucleus collisions. The EIC will provide complementary tools to investigate and constrain the initial state in HIC collisions, as well as transport properties of QCD matter which can be extracted from observables that are sensitive to final states interactions such as pt-broadening and energy loss. The contributed talks and discussions covered a variety of physics topics from saturation physics and the origin of multi-particle correlations in HIC to jet quenching and the strong coupl…
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (…
Convergence of dynamic programming principles for the $p$-Laplacian
2018
We provide a unified strategy to show that solutions of dynamic programming principles associated to the $p$-Laplacian converge to the solution of the corresponding Dirichlet problem. Our approach includes all previously known cases for continuous and discrete dynamic programming principles, provides new results, and gives a convergence proof free of probability arguments.