Search results for " PEG"

showing 8 items of 88 documents

Recombinant FVIII Products (Turoctocog Alfa and Turoctocog Alfa Pegol) Stable Up to 40°C

2021

Mariasanta Napolitano,1 Arne Agerlin Olsen,2 Anne Mette Nøhr,2 Hermann Eichler3 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo Reference Regional Center for Thrombosis and Hemostasis, Hematology Unit, Palermo, Italy; 2Novo Nordisk A/S, Biopharm Manufacturing Development, Gentofte, Denmark; 3Saarland University and Saarland University Hospital, Institute of Clinical Haemostaseology and Transfusion Medicine, Homburg (Saar), GermanyCorrespondence: Anne Mette NøhrBiopharm Manufacturing Development, Novo Nordisk A/S, Nybrovej 80, Gentofte 2820, DenmarkTel +45 3075 1619Email amnq@novonordisk.…

medicine.medical_specialtybusiness.industryturoctocog alfa pegolHematologyTuroctocog alfa030204 cardiovascular system & hematologyGastroenterologyJournal of Blood Medicine03 medical and health sciences0302 clinical medicinetemperature stabilityfactor VIII030220 oncology & carcinogenesisAmbient humidityInternal medicinehemic and lymphatic diseasesmedicinePotencyfactor VIII hemophilia A storage flexibility temperature stability turoctocog alfa turoctocog alfa pegolhemophilia Astorage flexibilityturoctocog alfabusinessHot and humidOriginal ResearchJournal of Blood Medicine
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Bone marrow evaluation according to the PVSG and WHO criteria in 90 essential thrombocythemia (ET) patients treated with PEG interferon alpha-2b. Pre…

2005

Abstract Ninety ET patients diagnosed according to the PVSG criteria were enrolled in a phase II study (sponsored by the Schering-Plough Company) designed to evaluate the efficacy, safety and tolerability of a two years treatment with PEG Interferon alpha-2 b (PEG Intron). The patients, observed in 16 Italian Centres belonging to the GIMEMA Cooperative Group and judged at high risk, had been previously treated with cytoreductive (97%) and antiplatelet (91%) drugs. At the study start the patients, 60 F and 30 M, mean age 45 years, showed splenomegaly in 22% of cases. The Hematological Response (HR: PLT<500 x109/L) was observed in 64/81 (79%) and 48/55 (87%) of the patients on PEG Intr…

medicine.medical_specialtythrombocythemia (ET) patientsImmunologyEssential Thrombocythemia (ET); PEG Interferon alpha-2b.Phases of clinical researchAlpha (ethology)BiochemistryGastroenterologyPEG Interferon alpha-2bFibrosisInternal medicinePEG ratioBiopsyMedicineEssential Thrombocythemia (ET)medicine.diagnostic_testbusiness.industryEssential thrombocythemiaCell BiologyHematologymedicine.diseaseSurgerymedicine.anatomical_structureTolerabilityBone marrow evaluationBone marrowbusiness
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Viabilità e adesione cellulare di cellule di epatocarcinoma umano su supporti 3D a base di poli(acido D,L lattico)

2011

scaffolds porosi PLA PEG
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The effect of processing and molecular weight of poly(ethylenglycol) of polylactide-based scaffolds on viability and cell adhesion of SkHep1 cells

2011

scaffolds PLA PEG
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Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.

2021

Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…

siRNA deliveryRNase PCellPharmaceutical Science02 engineering and technology010402 general chemistry01 natural sciencesArticleAnalytical Chemistrylcsh:QD241-441EGF; inulin; PEG; siRNA delivery; targeting; tumourlcsh:Organic chemistryEpidermal growth factorNeoplasmsDrug DiscoveryPEG ratioZeta potentialmedicineCopolymerHumansDoxorubicinPhysical and Theoretical ChemistryRNA Small InterferingtargetingEGFDrug CarriersinulinChemistrytumourOrganic ChemistryTransfection021001 nanoscience & nanotechnologyPEG0104 chemical sciencesNanostructuresmedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoChemistry (miscellaneous)BiophysicsMCF-7 CellsMolecular Medicine0210 nano-technologymedicine.drugMolecules (Basel, Switzerland)
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Riconfigurare i territori metroplitani. Forme di urbanizzazione e fenomeni di pressione insediativa sui sistemi di interesse naturale in Sicilia

2018

The consumption of the soil due to urbanization it is a phenomena already for many years under observations, but of which only the scientific environment has noticed the elevated environmental impact progress. From a disciplinary point of view, is possible to identify a line of research focusing on the analysis and identification of new morphologies of urbanization and on the interaction among different settlement patterns coexisting in a specific context. This reading complements with the scientific production about the forms of settlement pressure on environmental systems, producing change and deterioration on natural ecosystems and loss of biodiversity. A necessary reference for this lin…

tale percentuale se considerata per i comuni costieri supera il 75% del territorio urbanizzato. Nel caso dei sistemi naturali i fenomeni di pressione umana pesano su una situazione già critica data da una distribuzione puntuale delle aree protette. Il livello di frammentazione e isolamento di queste aree rischia di peggiorare. In Sicilia l'assenza di strumenti di valutazione ambientale e lo scollamento tra pianificazione urbana e regionale e pianificazione settoriale hanno determinato un inadeguato livello di controllo della pressione umana sui sistemi ambientali. Riguardo a questo quadro generale il presente documento presenta un chiarimento e una riformulazione del rapporto di reciprocità tra ambiente edificato e territorio aperto con l'obiettivo di individuare possibili strategie per gestire i fenomeni di dispersione urbana nel contesto metropolitano obiettivo principale delle politiche territoriali europee e di molte politiche nazionali degli Stati membri.Settore ICAR/20 - Tecnica E Pianificazione UrbanisticaIl consumo del suolo a causa dell'urbanizzazione è un fenomeno già da molti anni sotto osservazione ma di cui solo l'ambiente scientifico ha notato l'elevato impatto ambientale. Da un punto di vista disciplinare è possibile individuare una linea di ricerca incentrata sull'analisi e l'identificazione di nuove morfologie dell'urbanizzazione e sull'interazione tra i diversi modelli insediativi che coesistono in un contesto specifico. Questa lettura si integra con la produzione scientifica sulle forme di pressione insediativa sui sistemi ambientali producendo cambiamento e deterioramento degli ecosistemi naturali e perdita di biodiversità. Un riferimento necessario per questa linea sono gli studi sui processi di frammentazione (lineare concentrato misto) e quelli sulla segregazione degli habitat naturali e seminaturali (protetti o non protetti). Tali riferimenti si combinano con le analisi condotte sul processo di sostituzione dei sistemi naturali con l'ecomosaico artificiale. Lo stato dell'urbanizzazione in Sicilia è interessato dal fenomeno della dispersione urbana che a partire dagli anni Settanta ha contribuito fortemente a plasmare il territorio regionale sia dal punto di vista fisico che funzionale. Tale fenomeno ha interessato principalmente le aree marginali intorno alle aree metropolitane dove i terreni consumati dagli insediamenti a bassa densità abitativa rappresentano il 42% dell'intero territorio urbanizzatoSettore ICAR/21 - Urbanistica
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Oxidation-responsive and "clickable" poly(ethylene glycol) via copolymerization of 2-(methylthio)ethyl glycidyl ether

2016

Poly(ethylene glycol) (PEG) is a widely used biocompatible polymer. We describe a novel epoxide monomer with methyl-thioether moiety, 2-(methylthio)ethyl glycidyl ether (MTEGE), which enables the synthesis of well-defined thioether-functional poly(ethylene glycol). Random and block mPEG-b-PMTEGE copolymers (Mw/Mn = 1.05-1.17) were obtained via anionic ring opening polymerization (AROP) with molecular weights ranging from 5 600 to 12 000 g·mol-1. The statistical copolymerization of MTEGE with ethylene oxide results in a random microstructure (rEO = 0.92 ± 0.02 and rMTEG E = 1.06 ± 0.02), which was confirmed by in situ 1H NMR kinetic studies. The random copolymers are thermorespon…

thioether-functional PEGoxidation-responsiveEpoxide02 engineering and technology010402 general chemistry01 natural sciencesBiochemistryRing-opening polymerizationMicelleCatalysischemistry.chemical_compoundColloid and Surface ChemistryPolymer chemistryCopolymerMoiety2-(methylthio)ethyl glycidyl etherEthylene oxidepoly(ethylene glycol)sulfoniumGeneral Chemistry021001 nanoscience & nanotechnology0104 chemical sciencesmulti-functional PEGMonomerchemistryPEOpolyetherthermoresponsive0210 nano-technologyEthylene glycol
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Pore size graded scaffold for selective cellular permeation

2014

tissue engineering pore size graded scaffold PLA PEG
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