Search results for " POC"
showing 10 items of 90 documents
The relationship between stocking eggs in boreal spawning rivers and the abundance of brown trout parr
2015
Abstract Stocking with eggs has been widely used as a management measure to support degraded salmonid stocks. In Finland, Atlantic salmon and both sea-migrating and lake-migrating brown trout are stocked as eggs, alevins, fry, parr, and smolt, whereas trout are also stocked as mature fish. The aim of this stocking is to improve catches and to support collapsed spawning stocks. We assessed the success of stocking with brown trout eggs in a study of 17 Finnish boreal forest rivers, of which 9 were subject to egg stocking. All rivers contained some naturally spawning trout. In 16 rivers, including non-stocking years and unstocked rivers, egg stocking did not increase the total (wild and stocke…
Ladri di luce. Leonardo Sciascia e Piero Guccione tra bellezza e verità
2023
The unpublished correspondence between Leonardo Sciascia and Piero Guccione from 1975 to 1989 shows the profound charge of humanity that innervates the friendship between these two great Enlightenment leaders "upside down". A "correspondence of amorous senses", despite the inevitable ideological differences, which the letters reproduced here for the first time and the original contributions of the volume give us back, under the banner of the binomial "beauty-truth".
Association between periodontal disease and non-fatal ischemic stroke: a case-control study
2014
This study aimed to investigate the association between clinical and radiological markers of periodontal disease and ischemic stroke and to assess the potential influence of inflammatory response on the observed associations.A prospective case-control study including a series of 48 cases with a minor ischemic stroke and 47 controls was conducted at the University Hospital of Dijon. Vascular risk factors, clinical dental examination (plaque index, gingival index, percentage of pockets5 mm, percentage of bleeding on probing (BOP) sites), dental panoramic (bone loss) and biological parameters (CRP, total cholesterol, HDL, LDL, fasting glucose) were collected. Conditional regression analyses we…
Association between chronic dental infection and acute myocardial infarction.
2008
Introduction: In patients with cardiovascular diseases several risk factors such as high blood pressure, diabetes, smoking and drinking habits, genetic disposition, and chronic inflammation must be considered. The aim of this study was to investigate whether there is a correlation between dental origin infections and the presence of an acutemyocardialinfarction(AMI).Methods:Atotalof125 patients who had experienced a myocardial infarction and 125healthyindividualswereincludedinthisstudy.Theoral examination was carried out following the consent of the ethics committee and the National Board for Radiation Protection and included the number of teeth, endodontically treated teeth, periodontal sc…
A Definitive Pharmacophore Modelling Study on CDK2 ATP Pocket Binders: Tracing the Path of New Virtual High-Throughput Screenings
2020
Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidence indicate that excessive expression of CDK2s should cause abnormal cell cycle regulation. Therefore, since a long time, CDK2s have been considered potential therapeutic targets for cancer therapy. In this work, onehundred and forty-nine complexes of inhibitors bound in the CDK2-ATP pocket were submitted to short MD simulations (10ns) and free energy calculation. Comparison with experimental data (K<sub>i</sub>, K<sub>d</su…
Site-directed mutagenesis of odorant-binding proteins
2020
Modifying the affinity of odorant-binding proteins (OBPs) to small ligands by replacement of specific residues in the binding pocket may lead to several technological applications. Thanks to their compact and stable structures, OBPs are currently regarded as the best candidates to be used in biosensing elements for odorants and volatiles detection. The wide and rich information on the structure of these proteins both in their apo-forms and in complexes with specific ligands provides guidelines to design reliable mutants to monitor specific targets. The same engineered proteins may also find applications in the slow release of pheromones and other chemicals in the environment, as well as in …
Multitemporal Monitoring of Plant Area Index in the Valencia Rice District with PocketLAI
2016
Leaf area index (LAI) is a key biophysical parameter used to determine foliage cover and crop growth in environmental studies in order to assess crop yield. Frequently, plant canopy analyzers (LAI-2000) and digital cameras for hemispherical photography (DHP) are used for indirect effective plant area index (PAI(eff)) estimates. Nevertheless, these instruments are expensive and have the disadvantages of low portability and maintenance. Recently, a smartphone app called PocketLAI was presented and tested for acquiring PAI(eff) measurements. It was used during an entire rice season for indirect PAI(eff) estimations and for deriving reference high-resolution PAI(eff) maps. Ground PAI(eff) value…
Wiadomości o rudzkim opactwie cystersów – na podstawie dokumentu fundacyjnego z kapsuły czasu kościoła w Stanicy z 1802 r
2019
12 grudnia 2017 r. zdjęto krzyż z kulą z wieży kościoła parafialnego pw. św. Marcina w Stanicy – ostatniej świątyni zbudowanej przez opactwo cystersów w Rudach przed jego kasatą w 1810 r. W kapsule czasu znajdował się okolicznościowy zapis, sporządzony 20 września 1802 r. W oparciu o lekturę odkrytego dokumentu oraz dostępne opracowania na temat rudzkiego opactwa, autor omawia sytuację opactwa na początku burzliwego XIX w., a także charakteryzuje stan osobowy rudzkiego konwentu. W dalszej kolejności opisuje główne etapy budowy kościoła św. Marcina w Stanicy na kanwie dramatycznych dziejów zawieruchy napoleońskiej, posiłkując się kronikarskim zapisem ostatniej części odnalezionego dokumentu,…
Dynamic-shared Pharmacophore Approach as Tool to Design New Allosteric PRC2 Inhibitors, Targeting EED Binding Pocket.
2020
Abstract: The Polycomb Repressive complex 2 (PRC2) maintains a repressive chromatin state and silences many genes, acting as methylase on histone tails. This enzyme was found overexpressed in many types of cancer. In this work, we have set up a Computer-Aided Drug Design approach based on the allosteric modulation of PRC2. In order to minimize the possible bias derived from using a single set of coordinates within the protein-ligand complex, a dynamic workflow was developed. In details, molecular dynamic was used as tool to identify the most significant ligand-protein interactions from several crystallized protein structures. The identified features were used for the creation of dynamic pha…
Hydrophobic pocket targeting probes for enteroviruses
2015
Visualization and tracking of viruses without compromising their functionality is crucial in order to understand virus targeting to cells and tissues, and to understand the subsequent subcellular steps leading to virus uncoating and replication. Enteroviruses are important human pathogens causing a vast number of acute infections, and are also suggested to contribute to the development of chronic diseases like type I diabetes. Here, we demonstrate a novel method to target site-specifically the hydrophobic pocket of enteroviruses. A probe, a derivative of Pleconaril, was developed and conjugated to various labels that enabled the visualization of enteroviruses under light and electron micros…