Search results for " POM"

Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of the novel enzyme replacement therapy avalglucosidase alfa (neoG…

2019

This multicenter/multinational, open-label, ascending-dose study (NCT01898364) evaluated safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat-dose avalglucosidase alfa (neoGAA), a second-generation, recombinant acid α-glucosidase replacement therapy, in late-onset Pompe disease (LOPD). Patients ≥18 years, alglucosidase alfa naïve (Naïve) or previously receiving alglucosidase alfa for ≥9 months (Switch), with baseline FVC ≥50% predicted and independently ambulatory, received every-other-week avalglucosidase alfa 5, 10, or 20 mg/kg over 24 weeks. 9/10 Naïve and 12/14 Switch patients completed the study. Avalglucosidase alfa was well-tolerated; no deaths…

Mazā ērgļa Aquila pomarina C.L. Brehm taksonomija, izplatība, skaits un ekoloģija Latvijā

1999

Advisor: Vīksne, Jānis

Pomara Saverino, Bruno: Rifugiati. I moriscos e l'Italia

2018

2-propanol formation by propene hydration: Catalytic and catalytic photo- assisted reaction using H3PW12O40 supported on TiO2 and SiO2.

2012

L'appropriation par l'entreprise partenaire des résultats d'une thèse CIFRE : exemple d'une recherche portant sur la formation initiale des sapeurs-p…

2023

Strategies for improving production and purification of a recombinant protein: rP30 of Toxoplasma gondii expressed in the yeast Schizosaccharomyces p…

2007

Abstract Many problems concerned with the production and the purification of recombinant proteins must be addressed prior to launching an industrial production process. Among these problems, attention is focused on low-level expression that complicates the purification step and can jeopardise the process. The expression of a membrane protein, rP30, of Toxoplasma gondii in the yeast Schizosaccharomyces pombe led to a secretion of only 0.5 μg ml−1. In order to obtain a sufficient quantity for biochemical characterization and evaluation in vitro diagnostic test development, strategies for both production and purification had to be optimized. First, the influence of four nitrogen sources (three…

Consequences of food-attraction conditioning in Helix: a behavioral and electrophysiological study

1996

Food-attraction conditioning is a learning phenomenon by which adult Helix pomatia acquire the ability to locate food through exposure to that particular food. Food-conditioned snails can be distinguished from ‘naive’ snails during their approach to food. ‘Naive’ snails keep their tentacles upright — whereas ‘food-conditioned’ animals bend the tentacles down-ward, in a horizontal orientation, pointed in the direction of the food.

Nota minima sul comodato c.d. ad pompam vel ostentationem

2016

On the basis of the exegesis of certain texts in the Justinian’s Digest, namely 13.6.3.6 (Ulp. 28 ad ed.), 12.1.18.1 (Ulp. 7 disp.), 13.6.4 (Gai. 1 de verb. obl.), 46.3.67 (Marc. 13 dig.), the Author formulates some considerations on the commodatum so-called ad pompam vel ostentationem, pointing out that the applications related to that anomalous commodatum were more complex and not merely confined to the idea of exhibiting id quod usu non consumitur for ‘pomp’, id est (by doing) ‘ostentation’. The basic idea of the Author is that Ulpian has specifically designated two terms, ‘pompa vel ostentatio’, to refer to two different (but not opposing) application spheres, in an attempt to synthesis…

Pasajes de París / 4: Sus usos culturales

2006

Abalone (Haliotis tuberculata) hemocyanin type 1 (HtH1) . Organization of the = 400 kDa subunit, and amino acid sequence of its functional units f, g…

1999

We have identified two separate hemocyanin types (HtH1 and HtH2) in the European abalone Haliotis tuberculata. HtH1/HtH2 hybrid molecules were not found. By selective dissociation of HtH2 we isolated HtH1 which, as revealed by electron microscopy and SDS/PAGE, is present as didecamers of a approximately 400 kDa subunit. Immunologically, HtH1 and HtH2 correspond to keyhole limpet hemocyanin (KLH)1 and KLH2, respectively, the two well-studied hemocyanin types of the closely related marine gastropod Megathura crenulata. On the basis of limited proteolytic cleavage, two-dimensional immunoelectrophoresis, SDS/PAGE and N-terminal sequencing, we identified eight different 40-60 kDa functional unit…