Search results for " PROGRESS"

Assessing environmental performance in the European Union: Eco-innovation versus catching-up

2017

Abstract This paper assesses environmental performance in the European Union (EU) using Luenberger productivity indicators, directional distance functions and Data Envelopment Analysis techniques. It considers four indicators of the pressures exerted by economic activity on the environment: global warming, tropospheric ozone formation, acidification and particulate formation. The change in environmental performance from the early 2000s onwards is decomposed at the levels of country and environmental pressure, and as the result of eco-innovations and catching-up with the best available environmental technologies; furthermore, we distinguish between the periods of economic growth (2001–07) an…

Therapy with lamivudine and steroids in a patient with acute hepatitis B and rapidly progressive glomerulonephritis.

2006

To the Editor: Tang et al.1 recently reported that lamivudine (LAM) improves renal outcome in patients with chronic hepatitis B virus (HBV) infection and membranous nephropathy. We would like to add our experience on acute hepatitis B and rapidly progressive glomerulonephritis.

Messing Up the Cancer Stem Cell Chemoresistance Mechanisms Supported by Tumor Microenvironment

2021

Despite the recent advances in cancer patient management and in the development of targeted therapies, systemic chemotherapy is currently used as a first-line treatment for many cancer types. After an initial partial response, patients become refractory to standard therapy fostering rapid tumor progression. Compelling evidence highlights that the resistance to chemotherapeutic regimens is a peculiarity of a subpopulation of cancer cells within tumor mass, known as cancer stem cells (CSCs). This cellular compartment is endowed with tumor-initiating and metastasis formation capabilities. CSC chemoresistance is sustained by a plethora of grow factors and cytokines released by neighboring tumor…

A cross-country configurational approach to international academic mobility: exploring mobility effects on academics’ career progression in EU countr…

2022

This study takes a novel perspective on mobility as career script compliance to explore the factors that might influence how mobile academics in a country perceive the impact of international mobility on their overall academic career progression and job options. We conduct a country-level qualitative comparative analysis on a sample of 24 European Union (EU) countries, based on data from European Commission’s MORE3 indicator tool. We find that these perceptions about the impact are shaped by the dominant patterns of mobility in that country, and the general perception of academics in that particular country that international mobility is rewarded in the institutional promotion schemes. This…

SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B

2014

A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously dividing cancer cells might unbalance this ratio and critically affect tumour outgrowth. We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression. SCD5 is down-regulated in advanced melanoma and its restored expression significantly reduced melanoma malignancy, both in vitro and in vivo, through a mechanism governing the secretion of extracellular matrix proteins, such as secreted protein acidic and rich in cysteine (SPAR…

Comparison of global visual field indices (MD,VFI), GPA II change and cluster analysis of visual field progression in glaucoma

2014

Concorsi pubblici e progressioni di carriera nella stagione del "grande reclutamento"

2022

il saggio affronta i principali problemi del sistema dei concorsi pubblici e della disciplina delle progressioni di carriera nel pubblico impiego privatizzato, alla luce delle innovazioni contenute nel d.l. 80/2021 e nella della sottoscrizione del nuovo CCNL per il comparto Funzioni Centrali.

Follow-up in transthyretin familial amyloid polyneuropathy: Useful investigations

2020

Patients with transthyretin amyloid polyneuropathy (TTR-FAP) and asymptomatic mutation-carriers have to be regularly followed-up in order to identify disease progression and the time point for starting or modifying therapy. In this case series we describe the potential suitability of different variables as progression markers. We retrospectively analyzed the follow-up charts of 10 TTR-FAP patients. Clinical examination included the Neuropathy Impairment Score of Lower Limb (NIS-LL), temperature perception thresholds, nerve conduction and autonomic function tests. The NIS-LL had the greatest value for a sensitive and correct follow-up for all TTR-FAP stages. All other examinations provided u…

Enhanced Lipid Peroxidation and Platelet Activation in the Early Phase of Type 1 Diabetes Mellitus

2003

Background— To investigate early events possibly related to the development of diabetic angiopathy, we examined whether 8-iso-prostaglandin F 2α (8-iso-PGF 2α ) formation, a marker of in vivo oxidant stress, is altered in different stages of type 1 diabetes (T1DM) and whether it correlates with the rate of thromboxane (TX) A 2 biosynthesis, a marker of in vivo platelet activation. We also investigated the relationship between inflammatory markers and F 2 -isoprostane formation in this setting. Methods and Results— A cross-sectional study was performed in 23 insulin-treated patients aged <18 years with new-onset T1DM (≤6 weeks, group A), matched for age and gender with 23 patients with s…

Didactologies/didactique des langues-cultures et didactique de la musique du français: réflexion (s) en 2016

2016

Revenant aux sources de définitions de la Didactologie/didactique des languescultures élaborées par Robert Galisson dans les années 1985-1986 en particulier, on constate que le paysage didactique actuel est fortement marqué par la prépondérance du recours à divers modes d’application relativement contrôlables, alors que l’on aurait pu croire que cette tendance était de nos jours révolue. Cette démarche permet également de remarquer l’aide apportée par Robert Galisson pour la démonstration de la légitimité de la Didactique de la musique du français (1996) à une époque où le Cadre européen commun de référence pour les langues n’était pas encore paru ni appliqué. Ces rétrospections sont l’occa…