Search results for " PROGRESS"
showing 10 items of 1287 documents
Implantable Sensors Based on Gold Nanoparticles for Continuous Long-Term Concentration Monitoring in the Body.
2021
Implantable sensors continuously transmit information on vital values or biomarker concentrations in bodily fluids, enabling physicians to survey disease progression and monitor therapeutic success. However, currently available technologies still face difficulties with long-term operation and transferability to different analytes. We show the potential of a generalizable platform based on gold nanoparticles embedded in a hydrogel for long-term implanted biosensing. Using optical imaging and an intelligent sensor/reference-design, we assess the tissue concentration of kanamycin in anesthetized rats by interrogating our implanted sensor noninvasively through the skin. Combining a tissue-integ…
MUTUAL INDUCTANCE FOR AN EXPLICITLY FINITE NUMBER OF TURNS
2011
Non coaxial mutual inductance calculations, based on a Bessel function formulation, are presented for coils modelled by an explicitly flnite number of circular turns. The mutual inductance of two such turns can be expressed as an integral of a product of three Bessel functions and an exponential factor, and it is shown that the exponential factors can be analytically summed as a simple geometric progression, or other related sums. This allows the mutual inductance of two thin solenoids to be expressed as an integral of a single analytical expression. Sample numerical results are given for some representative cases and the approach to the limit where the turns are considered to be smeared ou…
Guanidinoacetate-creatine in secondary progressive multiple sclerosis: a case report.
2022
Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options. A 48-year-old woman with acute SPMS being treated with interferon beta-1a and oral corticosteroids presented as a clinical outpatient with no disease-modifying effects after treatment. A decision was made to treat her with a combination of guanidinoacetate and creatine for 21 days. She had made clinical progress at follow-up, with the intensity of fatigue dropping from severe to mild. Magnetic resonance spectroscopy revealed increased brain choline, creatine, N-acetylaspartate, and glutathione. Patients with SPMS may benefit from …
Cerebrospinal Fluid Analysis in Multiple Sclerosis Diagnosis: An Update
2019
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) with brain neurodegeneration. MS patients present heterogeneous clinical manifestations in which both genetic and environmental factors are involved. The diagnosis is very complex due to the high heterogeneity of the pathophysiology of the disease. The diagnostic criteria have been modified several times over the years. Basically, they include clinical symptoms, presence of typical lesions detected by magnetic resonance imaging (MRI), and laboratory findings. The analysis of cerebrospinal fluid (CSF) allows an evaluation of inflammatory processes circumscribed to the CNS and reflects chan…
CD28, a marker associated with tumoral expansion in multiple myeloma
1998
International audience; CD28 expression was thoroughly investigated on plasma cells of monoclonal gammopathy of undetermined significance, multiple myeloma (MM), and human myeloma cell lines. CD28+ plasma cells were detected in 19% of 31 monoclonal gammopathy of undetermined significance, 41% of 116 MM, and 100% of 13 human myeloma cell lines. CD28+ myeloma cells were detected in 21 of 79 (26%) MM cases at diagnosis, 13 of 22 (59%) at medullary relapse (P < 0.009), and 14 of 15 (93%) at extramedullary relapse (P = 0.05), including 10 of 10 (100%) secondary plasma cell leukemias (P = 0.05). Serial studies in individual patients confirmed the emergence of CD28+ myeloma cells with tumoral expa…
Adaptive surface compression with geometric wavelets.
2008
The recent advances in computer graphics and digitization allow access to an ever finer three-dimensional modelling of the world. The critical challenges with 3D models lie in their transmission and rendering, which must fit the heterogeneity of the end resources (network bandwidth, display terminals . . . ). In this context, this thesis investigates the progressive compression and transmission of 3D models, based on multiresolution analysis, to provide a scalable representation of these geometric models. This work is part of "CoSurf", a collaborative research project involving LIRIS laboratory and France Télécom R&D in Rennes. The proposed hierarchical compression method is based on a wave…
Acerca de los posibles progresos de la Metafísica
2016
Riprendere la domanda metafisica significa oggi esplicare il carattere circolare della sua indagine sui principi, che mostra una forma particolare di libertà e di criticità proprie del pensiero To resume metaphysical question it means today to explicit the circular nature of its investigation on the principles, showing a particular form of freedom and critical attitude of thought
Influence of heme oxygenase 1 modulation on the progression of murine collagen-induced arthritis.
2005
Contains fulltext : 48023.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Heme oxygenase 1 (HO-1) can be induced by inflammatory mediators as an adaptive response. The objective of the present study was to determine the consequences of HO-1 modulation in the murine collagen-induced arthritis (CIA) model. METHODS: DBA/1J mice were treated with an inhibitor of HO-1, tin protoporphyrin IX (SnPP), or with an inducer of HO-1, cobalt protoporphyrin IX (CoPP), from day 22 to day 29 after CIA induction. The clinical evolution of disease was monitored visually. At the end of the experiment, joints were examined for histopathologic changes. Cytokine levels in paws were measured by enzyme-linked…
Mutations of mitochondrial DNA and human death.
1990
In the skeletal muscle of patients with mitochondrial myopathies (Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia) and in the heart and skeletal muscle of healthy persons cells lacking cytochrome c oxidase are found. The respiratory-defective cells have the following features in common: onset of the defect at juvenile or adult age; progressive character of the defect with increasing age; and focal pattern of respiratory-deficient cells (fibers). A statistic mutation of mtDNA in affected cells is suggested to cause the defect of mitochondrial function. It is postulated that the continuous accumulation of respiratory-deficient cells, mainly in the human heart with incre…
Role of HLA-B α-3 domain amino acid position 194 in HIV disease progression
2013
HLA class I molecules play a role in the regulation of innate immune response. Therefore, the interaction of HLA class I molecules with different activating and inhibitory receptors leads to balancing the immune response. Among the different family of receptors, NK receptors KIR3DL1/S1 and LIR1, play a major role. Aim of this study was to evaluate the role of amino acid polymorphic positions of HLA class I molecules interacting with NK receptors in HIV progression. In order to minimize the influence of viral variability, a cohort of children with a nosocomial monophyletic HIV-1 infection from the Benghazi Children Hospital has been evaluated. To assess the role of single amino acid position…