Search results for " PROGRESS"

Roboti : "Es, topošais pilsonis" mācību resursi

2023

Izdevums "Es, topošais pilsonis" ir metodisks līdzeklis ekonomikas, pilsoniskās izglītības un ētikas mācību satura apguvei starpdisciplinārā pieejā, kas izstrādāti Erasmus+ KA2 projekta I, Citizen to Be ietvaros. Projekta materiāli sastāv no 12 nodarbībām: personība, nabadzība, roboti, ekoloģija, patērētājs, brīvprātīgais darbs, sociālie tīkli, viltus ziņas, darbs, veselība, maiņa, uzņēmējdarbība. Katra nodarbība ir sagatavota tā, lai tā atbilstu skolēnu vecuma grupai, kā arī sociālajai un kognitīvajai attīstībai. Katrai nodarbībai tiek piedāvāts ieteicamais mācību procesa apraksts, kas ietver 3 vai vairāk fragmentus. Katrā nodarbībā tiek aktualizēta konkrēta tēma, kas atspoguļo personīgo v…

EUROPEAN CONVERGENCE AND ITS IMPACT ON THE SOCIAL STRATEGY OF LATVIA

2014

The purpose of this study is to introduce evaluation of convergence policy activities in the European Union and to designate social development trends of Latvia in the context of reaching the goals of strategy “Europe 2020. The aim of the research has set the following tasks: to introduce the main EU social convergence theory investigations as the development challenges for improvement socio-economic well-being of the EU states; to evaluate current social situation and eventual social strategy of Latvia on 2014-2020; to estimate European convergence policy impact on the social development of Latvia. The strategic goals of EU policy are discussed as well as the development challenges for imp…

Progreso, complejidad y evolución

2020

Ensayos en honor de Eloy Rada. [ES]: El progreso biológico es un tema ampliamente debatido en biología evolutiva que tiene partidarios y detractores. Sin embargo, no es una cuestión, a pesar de su importancia, de la que podamos afirmar que está resuelta desde el punto de vista científico. En este trabajo presento un análisis del concepto basado en la teoría de la evolución por selección natural, sus paralelismos con el también debatido concepto de “progreso” en la historia de la humanidad y, finalmente, se intenta orientarlo hacia formas accesibles a la investigación científica. Para ello, en lugar del concepto de progreso, recurro al de “complejidad biológica”. Si tenemos formas de medirla…

Exploratory study about needs of disease progression in cancer patients

Background: Oncological disease progression can be difficult to manage for physicians, due to therapeutic switch after a previous treatments’ failure, but also because oncologist have to be linked with information about clinical conditions for patient reassurance. Our research considers person an integrated system, looking at fundamental needs of patients, according to theoretical and empirical basis of Neo-functionalism in psychology. Several studies report more unmet needs in patients affected by cancer, despite an increased attention about bad news communication. Previous studies in the field of healthcare have shown that both communication and psychological characteristics of patients a…

Roles of molecules involved in epithelial/mesenchymal transition during angiogenesis

2007

Formation of vessels requires "epithelial-mesenchymal" transition of endothelial cells, with several modifications at the level of endothelial cell plasma membranes. These processes are associated with redistribution of cell-cell and cell-substrate adhesion molecules, cross talk between external ECM and internal cytoskeleton through focal adhesion molecules and the expression of several proteolytic enzymes, including matrix metalloproteases and serine proteases. These enzymes with their degradative action on ECM components, generate molecules acting as activators and/or inhibitors of angiogenesis. The purpose of this review is to provide an overview of the molecules involved in epithelial-m…

Nephrogenic systemic fibrosis--a rapidly progressive disabling disease with limited therapeutic options.

2009

Background Nephrogenic systemic fibrosis (NSF) affects some patients on dialysis after gadolinium contrast agent–enhanced magnetic resonance imaging. It is characterized by progressive skin fibrosis of the extremities, sometimes including the trunk and internal organs. Methods The clinical course of 10 patients with biopsy-proven NSF was analyzed retrospectively with regard to gadolinium exposition, disease onset, and progression of NSF with special emphasis on physical mobility and impact of different therapeutic approaches. Results Despite physiotherapy and different additional therapeutic approaches (eg, immunosuppression, ultraviolet A-1 phototherapy, or extracorporal photopheresis) all…

Small renal tumors: correlation of clinical and pathological features with tumor size.

2007

We analyzed the association between tumor diameter and pathological stage, histological subtype, tumor grade and the incidence of metastases in renal cell carcinoma with a diameter of up to 4 cm (clinical stage T1a).We analyzed a consecutive series of 663 patients with renal tumors 4 cm or less who underwent surgery at our institution between 1990 and 2006. After excluding 115 patients (17.3%) with benign tumors 548 with renal cell carcinoma were included in the study. Tumor size on preoperative imaging was correlated with pathological stage, tumor grade, histological subtype and incidence of metastases at diagnosis. For data analysis tumors were stratified by tumor diameter into 3 groups, …

Multiplicity and history have a detrimental effect on survival in patients with T1G3 bladder tumors selected for conservative treatment.

2008

Purpose: In the absence of Tis tumor we assessed whether history and multiplicity have a detrimental effect on conservative treatment in carefully selected patients with T1G3 bladder carcinoma. Materials and Methods: Between January 1976 and December 1999, 165 select patients with T1G3 bladder tumors were conservatively treated with transurethral resection plus adjuvant intravesical therapy. Patients with concomitant or previous Tis, previous T1G3, tumor size greater than 3 cm and more than 3 lesions were excluded from analysis. Repeat transurethral resection was not routinely performed. However, cytology had to be negative for atypia before the start of adjuvant intravesical therapy. Resul…

Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG: not as bad as pr…

2018

PURPOSE: The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis to adequately stage and treat the patient. Persistent disease after TUR is not uncommon and is why re-TUR is recommended in T1G3 patients. When there is T1 tumor in the re-TUR specimen, very high risks of progression (82%) have been reported. We analyze the risks of recurrence, progression to muscle-invasive disease and cancer-specific mortality (CSM) according to tumor stage at re-TUR in T1G3 patients treated with BCG. METHODS: In our retrospective cohort of 2451 T1G3 patients, 934 patients (38.1%) underwent re-TUR. 667 patients had residual disease (7…

Parenchyma-sparing surgery for renal tumors

1991

Between 1969 und 1989 conservative surgery for kidney tumors was performed in 123 patients. In 49 patients there was an imperative indication for a parenchyma-sparing operation because nephrectomy would have made dialysis obligatory. Thirty-five of these 49 patients show no signs of tumor progression after a mean follow-up of 4.5 years. Known metastases were present in 3 of 6 patients who died as a result of their tumors. In two patients there was a recurrence after 1 and 5 years, respectively, requiring a second organ-preserving operation. In one further patient we suspect that multiple small tumor lesions may be present 2 years after the first operation. In 74 patients with a healthy cont…