Search results for " PSYCHOSIS"

showing 10 items of 120 documents

Gene-environment interaction as a predictor of early adjustment in first episode psychosis.

2017

Abstract Background This study aims to explore the gene-environment interaction hypothesis applied to pre-symptomatic neurodevelopmental phenotypes of first episode psychosis (FEP), that is, genetic factors might increase vulnerability to the effects of environmental adverse conditions occurring at later stages of development. Methods We constructed a schematic ‘two-hit’ model, with Val/Val homozygosity for the catechol- O -methyltransferase ( COMT ) Val158Met polymorphism as the ‘first hit’ and history of obstetric complications and parental socioeconomic status as ‘second hits’. Early adjustment, measured using the Premorbid Adjustment Scale, was considered the main outcome. The study pop…

AdultMaleParentsmedicine.medical_specialtyGenotypePremorbid Adjustment ScaleCatechol O-MethyltransferasePolymorphism Single NucleotideStatistics Nonparametric03 medical and health sciencesYoung Adult0302 clinical medicineMethioninePolymorphism (computer science)First episode psychosismedicineHumansGenetic Predisposition to DiseaseGene–environment interactionPsychiatrySocioeconomic statusBiological PsychiatryRetrospective StudiesAdverse conditionsValinemedicine.disease030227 psychiatryPsychiatry and Mental healthPsychotic DisordersSchizophreniaPopulation studyFemaleGene-Environment InteractionPsychology030217 neurology & neurosurgeryDemographySchizophrenia research
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Differences in cannabis-related experiences between patients with a first episode of psychosis and controls

2016

BackgroundMany studies have reported that cannabis use increases the risk of a first episode of psychosis (FEP). However, only a few studies have investigated the nature of cannabis-related experiences in FEP patients, and none has examined whether these experiences are similar in FEP and general populations. The aim of this study was to explore differences in self-reported cannabis experiences between FEP and non-psychotic populations.MethodA total of 252 subjects, who met International Classification of Diseases (ICD)-10 criteria for FEP, and 217 controls who reported cannabis use were selected from the Genetics and Psychosis (GAP) study. The Medical Research Council Social Schedule and t…

AdultMalePsychosismedicine.medical_specialtyExacerbationPopulationMarijuana SmokingSociodemographic datapsychosiPsychotic Disorder03 medical and health sciencesYoung Adult0302 clinical medicineexperienceSurveys and QuestionnairesmedicineSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.HumansSurveys and QuestionnaireCannabiYoung adulteducationPsychiatrySettore MED/25 - PsichiatriaApplied PsychologyCannabisCannabis; Cannabis Experience Questionnaire; experiences; first episode of psychosis; psychosis; Adult; Cannabis; Female; Humans; Linear Models; Male; Marijuana Smoking; Psychiatric Status Rating Scales; Psychotic Disorders; Surveys and Questionnaires; Young Adult; Applied Psychology; Psychiatry and Mental Healthfirst episode of psychosiFirst episodePsychiatric Status Rating Scaleseducation.field_of_studybiologyCannabis usePsychiatric Status Rating Scalemedicine.diseasebiology.organism_classification030227 psychiatryPsychotic DisordersPsychiatry and Mental HealthCannabis Experience QuestionnaireLinear ModelsLinear ModelFemaleCannabisPsychology030217 neurology & neurosurgeryClinical psychologyHuman
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Duration of active psychosis and functional outcomes in first-episode non-affective psychosis.

2018

AbstractBackground:The duration of untreated psychosis (DUP) has been associated with negative outcomes in psychosis; however, few studies have focused on the duration of active psychotic symptoms after commencing treatment (DAT). In this study, we aimed to evaluate the effect of DUP and DAT on functional long-term outcomes (3 years) in patients with early psychosis.Methods:We evaluated the Scale for the Assessment of Positive Symptoms (SAPS) at frequent intervals for 3 years after presentation to determine the DAT for 307 individuals with first-episode psychosis together with DUP and clinical variables. The functional outcomes were assessed using the Disability Assessment Scale (DAS) at th…

AdultMalePsychosismedicine.medical_specialtyTime FactorsLogistic regressionCohort Studies03 medical and health sciencesDisability Evaluation0302 clinical medicineActivities of Daily LivingmedicineHumansProspective StudiesPsychiatryProspective cohort studyFirst episodePsychiatric Status Rating ScalesReceiver operating characteristicbusiness.industrymedicine.disease030227 psychiatryPsychiatry and Mental healthTreatment OutcomePsychotic DisordersSchizophreniaNon affective psychosisdupSchizophreniaFemaleSchizophrenic PsychologybusinessSocial Adjustment030217 neurology & neurosurgeryAntipsychotic AgentsEuropean psychiatry : the journal of the Association of European Psychiatrists
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ReMindCare App for Early Psychosis: Pragmatic Real World Intervention and Usability Study

2020

[EN] Background: eHealth interventions are widely used in clinical trials and increasingly in care settings as well; however, their efficacy in real-world contexts remains unknown. ReMindCare is a smartphone app that has been systematically implemented in a first episode of psychosis program (FEPP) for patients with early psychosis since 2018. Objective: The objective of this study was to assess the efficacy of ReMindCare after 19 months of use in the clinic and varying use by individual patients. Methods: The integration of the ReMindCare app into the FEPP started in October 2018. Patients with early psychosis self-selected to the app (ReMindCare group) or treatment as usual (TAU group). T…

AdultMaleTelemedicine020205 medical informaticsEuropean Regional Development FundHealth Informatics02 engineering and technologyClinical practiceReal-world intervention03 medical and health sciences0302 clinical medicineNursingIntervention (counseling)Political science0202 electrical engineering electronic engineering information engineeringAmbulatory CareCIENCIAS DE LA COMPUTACION E INTELIGENCIA ARTIFICIALmedia_common.cataloged_instanceHumansPsiquiatriaEuropean unionSalut mentalmedia_commonOriginal Paperbusiness.industryEarly psychosisUsabilityPsychosisMental healthMobile ApplicationsTelemedicine030227 psychiatryClinical PracticePsychotic DisordersFemaleMental healthSmartphonebusinessApp
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Interaction between cannabis consumption and childhood abuse in psychotic disorders:preliminary findings on the role of different patterns of cannabi…

2014

Aim: Several studies have suggested that lifetime cannabis consumption and childhood abuse synergistically contribute to the risk for psychotic disorders. This study aimed to extend existing findings regarding an additive interaction between childhood abuse and lifetime cannabis use by investigating the moderating role of type and frequency of cannabis use. Methods: Up to 231 individuals presenting for the first time to mental health services with psychotic disorders and 214 unaffected population controls from South London, United Kingdom, were recruited as part of the Genetics and Psychosis study. Information about history of cannabis use was collected using the Cannabis Experiences Questi…

AdultMalecannabischildhood traumaAdult Survivors of Child AbuseinteractionMarijuana SmokingComorbiditymarijuana smokingYoung Adultcannabis childhood trauma first-episode psychosis interaction marijuana smokingPsychotic DisordersRisk FactorsSurveys and QuestionnairesSettore M-PSI/08 - Psicologia ClinicaLondonSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.HumansFemalefirst-episode psychosisCannabis childhood trauma first-episode psychosis interaction marijuana smokingSettore MED/25 - Psichiatria
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Auditory hallucinations in first-episode psychosis: A voxel-based morphometry study

2019

Abstract Background Auditory hallucinations (AH) are a core symptom of psychosis. The brain abnormalities responsible for AH remain controversial due to inconsistent and conflicting findings across studies, with substantial confounding factors, such as chronicity. Few studies have examined the pathological changes that occur in the gray matter (GM) of patients with first-episode psychosis (FEP) and AH. The present study aims to validate the presence and characteristics of these structural abnormalities in relation to the intensity of psychotic symptoms and AH in a larger homogeneous sample than those of previous studies. Methods A magnetic resonance voxel-based morphometric analysis was app…

AdultMalemedicine.medical_specialtyPsychosisAdolescentHallucinationsGyrus CinguliGastroenterologyYoung Adult03 medical and health sciences0302 clinical medicineFirst episode psychosisInternal medicinemedicineHumansGray MatterYoung adultPathologicalBiological PsychiatryCerebral Cortexmedicine.diagnostic_testbusiness.industryConfoundingCase-control studyMagnetic resonance imagingOrgan SizeVoxel-based morphometrymedicine.diseaseMagnetic Resonance ImagingTemporal LobeFrontal Lobe030227 psychiatryPsychiatry and Mental healthPsychotic DisordersCase-Control StudiesFemalebusiness030217 neurology & neurosurgerySchizophrenia Research
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Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study

2019

BACKGROUND: There is a paucity of longitudinal research investigating vitamin D in people with early psychosis.METHOD: Vitamin D levels were measured in 168 patients (64% (n = 108) male, mean age 29.3 (9.8) years) with first episode psychosis (FEP), along with measures of clinical state at baseline and at 12 months follow up. We assessed the a) cross sectional, and; b) longitudinal relationships between continuous and categorical 25-hydroxyvitamin D (25(OH)D) levels and clinical symptoms at first contact for psychosis and at 12 months.RESULTS: In FEP, 80% (n = 134) at baseline, and 76% at 12 months follow up, had suboptimal vitamin D levels (<20 ng/ml). Suboptimal levels of 25 (OH) D at …

AdultMalemedicine.medical_specialtyPsychosisCognitiveCross-sectional studyYoung Adult03 medical and health sciences0302 clinical medicineInternal medicineFirst episode psychosismedicineVitamin D and neurologyHumansLongitudinal StudiesProspective Studies25-hydroxyvitamin D (25(OH)D)Vitamin DYoung adultProspective cohort studyBiological PsychiatryNegative symptombusiness.industryFEPPsychosismedicine.disease030227 psychiatryPsychiatry and Mental healthCross-Sectional StudiesPsychotic DisordersSchizophreniaLongitudinalSchizophreniaFemaleNegative symptomsbusiness030217 neurology & neurosurgerySchizophrenia Research
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Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users.

2012

Background Cannabis use is associated with an increased risk of psychosis. One study has suggested that genetic variation in the AKT1 gene might influence this effect. Methods In a case-control study of 489 first-episode psychosis patients and 278 control subjects, we investigated the interaction between variation at the AKT1 rs2494732 single nucleotide polymorphism and cannabis use in increasing the risk of psychosis. Results The rs2494732 locus was not associated with an increased risk of a psychotic disorder, with lifetime cannabis use, or with frequency of use. We did, however, find that the effect of lifetime cannabis use on risk of psychosis was significantly influenced by the rs24947…

AdultMalemedicine.medical_specialtyPsychosisMarijuana AbuseEpisode of CarePolymorphism Single NucleotideRisk AssessmentOddsInternational Classification of DiseasesRisk FactorsLondonSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.medicineConfidence IntervalsOdds RatioHumansGenetic Predisposition to DiseaseGenetic TestingGene–environment interactionPsychiatrySettore MED/25 - PsichiatriaBiological PsychiatryDemographybiologyCase-control studyOdds ratiomedicine.diseasebiology.organism_classificationConfidence intervalPsychotic DisordersSocioeconomic FactorsCase-Control StudiesFemaleGene-Environment InteractionAKT1 gene cannabis use gene environment interaction psychosis schizophrenia signaling pathwaysCannabisRisk assessmentPsychologyProto-Oncogene Proteins c-aktDemographyBiological psychiatry
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Cannabis users have higher premorbid IQ than other patients with first onset psychosis.

2013

Background: A number of studies have reported that patients with psychosis who use cannabis have better cognitive performance than those who do not. This is surprising as cannabis can impair cognition in healthy subjects. An obvious question is whether the better current performance of psychotic patients who have used cannabis is a reflection of their having a higher premorbid IQ than those psychotic patients who haven't used cannabis. Aim: In a sample of patients at their first episode of psychosis, we tested the hypothesis that patients who smoked cannabis would have a higher premorbid IQ than patients who did not. Methodology: 279 participants (119 patients and 160 healthy controls) were…

AdultMalemedicine.medical_specialtyPsychosisMarijuana AbuseFirst Episode of Psychosis (FEP)Premorbid IQIntelligenceNeuropsychological TestsSubstance usebehavioral disciplines and activitiesYoung AdultCognitionSettore M-PSI/08 - Psicologia Clinicamental disordersmedicineHumansEffects of sleep deprivation on cognitive performanceCannabiYoung adultCannabis; Cognition; First Episode of Psychosis (FEP); IQ; Premorbid IQ; Risk of psychosis; Schizophrenia; Substance useRisk of psychosiPsychiatryBiological PsychiatryFirst episodeIntelligence TestsPsychiatric Status Rating ScalesAnalysis of VarianceChi-Square DistributionIntelligence quotientbiologymedicine.diseasebiology.organism_classificationPsychiatry and Mental healthPsychotic DisordersSchizophreniaIQSchizophreniaFemaleCannabisPsychologyhuman activitiesChi-squared distributionClinical psychology
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2018

AbstractBackgroundThe value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics of psychopathology at First Episode Psychosis (FEP). Regardless of diagnostic categories, we expected that positive symptoms occurred more frequently in ethnic minority groups and in more densely populated environments, and that negative symptoms were associated with indices of neurodevelopmental impairment.MethodThis study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying G…

Affective psychosisPsychosisEthnic groupContext (language use)medicine.disease030227 psychiatry03 medical and health sciencesPsychiatry and Mental health0302 clinical medicineSchizophreniaFirst episode psychosismedicineBipolar disorder10. No inequalityPsychology030217 neurology & neurosurgeryApplied PsychologyPsychopathologyClinical psychologyPsychological Medicine
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