Search results for " Park"
showing 10 items of 355 documents
Búsqueda de compuestos con potencial terapéutico para la enfermedad de Parkinson y estudio de la relación entre la enfermedad de Parkinson y la Diabe…
2022
La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más frecuente. Actualmente, la EP no tiene cura, y las terapias existentes solo son capaces de tratar los síntomas de esta enfermedad, pero no de ralentizar o de parar su progresión. Con el objetivo de descubrir nuevos fármacos que pudieran ser útiles para tratar esta enfermedad, hemos realizado un rastreo a gran escala, evaluando los compuestos incluidos en la quimioteca Prestwick (1120 compuestos). Para ello, estudiamos el efecto de estos compuestos sobre la actividad motora en un modelo de la EP en Drosophila basado en la mutación del gen DJ-1beta (ortólogo del gen humano DJ-1, cuya mutación es causante de casos f…
A Diet for Dopaminergic Neurons?
2009
Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive rate. Nevertheless, there is at present no cure for PD. Although there are no proven therapies for prevention, a large body of evidence from animal studies has highlighted the paramount role of dietary factors in counteracting DA degeneration. Consistently, associations between the risk of developing PD and the intake of nutrients, individual fo…
Park Parking
2019
The book containing this project, presents the outcomes of the 1st International Workshop “Dubai Pop-Up: Architecture in a Transient City” organized in March 2017 at d3-Dubai Design District by Al Ghurair University in collaboration with other international academic partners. Local students of architecture worked together with students coming from an international background, in order to foster a shared design vision through a collective cultural growth and reciprocal awareness. The participants had the opportunity to visit both recent accomplished buildings and projects under construction, confronting themselves with the local context in a dynamic and stimulating environment. The workshop …
Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease
2009
BACKGROUND: The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis. METHODS: In a series of experiments, we applied repetitive transcranial magnetic stimulation (rTMS) over the lateral cerebellum in a group of patients with advanced Parkinson disease, to investigate whether modulation of cerebellothalamocortical circuits…
Permanent Stations for Calibration/Validation of Thermal Sensors over Spain
2016
The Global Change Unit (GCU) at the University of Valencia has been involved in several calibration/validation (cal/val) activities carried out in dedicated field campaigns organized by ESA and other organisms. However, permanent stations are required in order to ensure a long-term and continuous calibration of on-orbit sensors. In the framework of the CEOS-Spain project, the GCU has managed the set-up and launch of experimental sites in Spain for the calibration of thermal infrared sensors and the validation of Land Surface Temperature (LST) products derived from those data. Currently, three sites have been identified and equipped: the agricultural area of Barrax (39.05 N, 2.1 W), the mars…
La movilización ciudadana para la conservación de la naturaleza: democracia, autonomía y áreas protegidas
2023
El presente artículo profundiza en el papel que tuvieron los movimientos sociales en la configuración de la política conservacionista de las décadas de los 70, 80 y 90 en los territorios de Catalunya, Comunitat Valenciana y Andalucía. A través de una investigación cualitativa basada en entrevistas en profundidad y en el análisis documental, abordamos desde una perspectiva comparada cómo la movilización ciudadana y el asociacionismo científico y académico influyeron en la declaración de los primeros parques naturales a través del apoyo o el rechazo a las iniciativas de conservación.
The Current State of Phyto-Coenological Research in the “Iron Gates” Danube Gorge (Banat, Romania)
2014
Abstract The author of the study writes a concise history of the phyto-coenological research conducted previously in the Danube Gorge; he notes the papers and the respective publishing years for the botanists who contributed with research to the knowledge of the cormophyte vegetation along the aforementioned sector of the Danube River. 55 important papers are highlighted, authored by fifty-four specialists in the years 1931-2006.
Management of Alluvial Forests Included in Natura 2000 91E0* Habitat Type in Maramureş Mountains Nature Park
2015
Abstract The Natura 2000 habitat type 91E0* Alluvial forests of Alnus glutinosa and Fraxinus excelsior (Alno-Padion, Alnion incanae, Salicion albae) include three subtypes of forests. In the Maramureș Mountains Nature Park (MMNP) the alluvial forests are represented by Alnus incana forest situated on the banks of mountain rivers. Starting from 2007, 70% of the MMNP is also a Natura 2000 site of community interest. In the standard form for the site are listed 18 Natura 2000 habitat types, but that of alluvial forests 91E0* is not listed either due to an error or lack of available research data. Our study seeks to provide information regarding this high conservation value habitat such as: str…
Assessing the efficacy of direct conservation interventions: clutch protection of the leatherback marine turtle in the Dominican Republic
2014
AbstractThe beaches of Jaragua National Park in the Dominican Republic are the country's last known major nesting site for the leatherback marine turtle Dermochelys coriacea. This nesting aggregation is threatened by widespread illegal egg take, and clutch relocation and artificial incubation have been carried out as protection measures since 1974. We assess the efficacy of such efforts and investigate how artificial incubation may be influencing the success and sex ratios of clutches. We compare hatching success, incubation duration and embryo mortality in in-situ clutches (n = 43) with those incubated artificially at sites in the east and west of the Park (n = 35 and n = 31, respectively)…
Towards sustainable coexistence: People and wild mammals in Baluran National Park, Indonesia
2018
Abstract The paper offers a critical discussion of resource use in a national park, Baluran, in Indonesia. In general, an increasing accept of the need for livelihood security, also for people living in or near natural conservation areas, are challenging traditional systems of national park governance. Finding ways to balance the needs of local populations against the necessity to secure biodiversity and environmental sustainability becomes important, and the main question in our research is how to accommodate an existing society in Baluran without a further negative impact on endangered mammals. Based on common pool resource management and co-management theories and thorough empirical inve…