Search results for " Parkinson"
showing 10 items of 115 documents
Non-occlusive mesenteric Ischemia (NOMI) in Parkinsonâs disease: Case report
2017
Non-occlusive mesenteric ischemia (NOMI) is a severe pathological condition characterized by signs and symptoms of bowel obstruction, intestinal necrosis resulting from acute and/or chronic inadequate blood perfusion, in the absence of an organic vascular obstruction detectable by imaging techniques. A 64 years old man case with a history of Parkinsonâs disease in high-functioning levodopa treatment is presented. Clinical and radiological signs of intestinal obstruction were observed. He underwent surgical operation with total colectomy and terminal ileostomy for generalized secondary peritonitis due to perforation of sigmoid colon. Ischemic pancolitis was first suspected. In third post-o…
Ambulante Therapie & Telemonitoring von Patienten mit Parkinson
2011
Körpernahe Sensornetzwerke können schon heute zur Steigerung der Lebensqualität beitragen, indem der Patient sein gewohntes Umfeld nicht zwingend verlassen muss. Der natürliche und nächste Schritt zur Verbesserung dieser wertvollen Diagnosesysteme beruht auf die Einbeziehung körpernaher Aktuatoren, welche auch eine gleichzeitige Therapierung erlauben. Durch einen interdisziplinären Ansatz, der klinische und technologische Erkenntnisse vereint, entsteht ein Sen-sor- und Aktuatornetzwerk, das am Beispiel eines sich in Entwicklung befindlichen innovativen Systems zur Behandlung von Parkinson vorgestellt wird.
Nitric oxide: Implications for the etiology & treatment of central nervous system disorders
2011
Surgery of Parkinson's disease. Experience in Messina
2003
No abstract
E163L HOMOZYGOUS DJ-1 MUTATION IN A FAMILY FROM SOUTHERN ITALY WITH AMIOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX.
2004
Effects of mutations of wild-type alpha-synuclein on its structure and dimerization and consequences for the Parkinson's disease : answers from coars…
2022
Alpha-synuclein is a protein of 140 amino acids, intrinsically disordered and found abundantly in the brain and whose toxic aggregation there is the hallmark of the Parkinson's disease.The aim of the thesis is to understand the effects of certain mutations on the dimerization of alpha-synuclein and to contribute to understand its involvement in Parkinson's disease by using coarse-grained molecular dynamics. Coarse-grained molecular dynamics trajectories were computed using the UNited-RESidue (UNRES) program and provided unprecedented sampling (over an effective time of the order of milliseconds) of the alpha-synuclein structures in monomeric and dimeric forms. These data were generated both…
Commentary: Anderson‐Fabry Disease: A Rare Cause of Levodopa‐Responsive Early Onset Parkinsonism
2021
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Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
2020
Neurodegenerative diseases such as Alzheimer&rsquo
Early DEtection of wEaring off in Parkinson disease: The DEEP study
2014
Assessing the frequency of Wearing-Off (WO) in Parkinson's disease (PD) patients, and its impact on Quality of Life (QoL). METHODS: Consecutive ambulatory patients, who were on dopaminergic treatment for ≥ 1 year, were included in this multicentre, observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as using the validated Italian version of a patient self-rated 19-question Wearing-Off Questionnaire (WOQ-19); WO was defined for scores ≥ 2. QoL was evaluated by the 8-item Parkinson's Disease Questionnaire (PDQ-8). RESULTS: 617 subjects were included, with a mean anti-Parkinson treatment duration of 6.6 ± 4.6 years, 87.2% were on lev…
A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial
2021
Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. Objective: To describe the occurrence of adverse events in PD patients treated with safinamide in real-life conditions. Methods: The SYNAPSES trial is an observational, European, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months with analyses performed in the overall population and in patients aged >75 years, with relevant comorbi…