Search results for " Perspective"

Sortase A Inhibitors: Recent Advances and Future Perspectives

2015

Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as antivirulence drugs. Sortase A is a polypeptide of 206 amino acids, which catalyzes two sequential reactions: (i) thioesterification and (ii) transpeptidation. Sortase A is involved in the process of bacterial adhesion by anchoring LPXTG-containing proteins to lipid II. Sortase A inhibitors do not affect bacterial growth, but they restrain the virulence of pathogenic bacterial strains, thereby preventing infections caused by Staphylococcus aureus or other Gram-positive bacteria. The efficacy of the most promising inhibitors needs to be com…

Moliner, C.; Cropanzano, R.; Martínez-Tur, V. (eds.) (2017). Organizational Justice: International perspectives and conceptual advances. Routledge.

2019

Untangling the roles of low skill and education in predicting youth NEET statuses: negative signalling effects in comparative perspective

2021

International audience; Education determines life chances across the globe, but human capital and skill formation offer context-specific advantages in the labour market during the transition from school to work. Our study focuses specifically on the varying effects of low skill on youth ‘not in employment, education or training’ (NEET) statuses via educational attainments. Using Programme for the International Assessment of Adult Competencies (PIAAC) data, we estimate the extent to which country-specific relative low skill levels affect young people’s probability of reporting long-term NEET statuses across contexts. We find that low skill and education have differing effects on the probabil…

Synaptic connectivity of the cholinergic axons in the olfactory bulb of the cynomolgus monkey.

2015

The olfactory bulb (OB) of mammals receives cholinergic afferents from the horizontal limb of the diagonal band of Broca (HDB). At present, the synaptic connectivity of the cholinergic axons on the circuits of the OB has only been investigated in the rat. In this report, we analyze the synaptic connectivity of the cholinergic axons in the OB of the cynomolgus monkey (Macaca fascicularis). Our aim is to investigate whether the cholinergic innervation of the bulbar circuits is phylogenetically conserved between macrosmatic and microsmatic mammals. Our results demonstrate that the cholinergic axons form synaptic contacts on interneurons. In the glomerular layer, their main targets are the peri…

The moderating role of personality in the relationship between temporal perspectives and facebook addiction

2020

In the present paper, we tested the hypothesis that neuroticism moderates the relationship between past-negative or present-fatalistic temporal perspectives and Facebook addiction. A sample of 233 Facebook users (Female: 66%, mean age: 21.4 years) filled self-reports measures of temporal perspective, personality traits, and Facebook Addiction. Results at two moderation models showed that only past-negative significantly predicts Facebook addiction through neuroticism's moderation effect. Individuals with a negative temporal orientation to the past, who are also characterized by a high neuroticism level, were more addicted to Facebook. Peculiar associations between past-negative temporal per…

Characterization of neutrophil subsets in healthy human pregnancies

2014

We have previously shown that in successful pregnancies increased arginase activity is a mechanism that contributes to the suppression of the maternal immune system. We identified the main type of arginase-expressing cells as a population of activated low-density granulocytes (LDGs) in peripheral blood mononuclear cells and in term placentae. In the present study, we analyzed the phenotype of LDGs and compared it to the phenotype of normal density granulocytes (NDGs) in maternal peripheral blood, placental biopsies and cord blood. Our data reveal that only LDGs but no NDGs could be detected in placental biopsies. Phenotypically, NDGs and LDGs from both maternal and cord blood expressed diff…

¿Un transhumanismo nietzscheano? Sobre la parcialidad del alegato

2020

espanolEl articulo analiza desde una perspectiva critica las tentativas de interpretar a Nietzsche como un precursor del transhumanismo. Tras una breve contextualizacion del fecundo debate en torno a Nietzsche y el transhumanismo, se evalua el caracter fraccional o parcial del alegato de Stefan Sorgner en favor de un “transhumanismo nietzscheano”. Despues, se investiga la tension entre humanidad, la superacion del ser humano y su cria en los escritos de Nietzsche. Una vez ejecutado este analisis, y sin animo de caer en el anacronismo, se sostiene que Nietzsche anticipa ciertamente un germen de la idea de post-humanidad, en su critica de la cultura humanista y en su invitacion a transformar …

Engaging with mathematics in the kindergarten. Orchestrating a fairy tale through questioning and use of tools

2013

ABSTRACTThe aim of this study is to analyse how a kindergarten teacher orchestrated a mathematical activity involving a fairy tale. Taking a sociocultural perspective on learning and development, naturally occurring talk-in-interaction has been analysed in order to scrutinise the subtleties of the orchestration. The fairy tale Goldilocks and the Three Bears was used both as context for the activity, but also as a means through which mathematical concepts were engaged with. The analysis shows that the orchestration bears characteristics of questioning and use of tools such as voice, facial expressions, and concrete materials. The orchestration is also characterised by sincere planning in adv…

Professionals' naming of intellectual disability, past and present practice and rationales

2011

The study illuminates four research questions: What terms for the diagnosis ICD10: F70-79 do Norwegian professionals utilize in their work? Which changes of terminology have professionals experienced? How do professionals explain such changes? Is there a substantive explanation? A semi-structured qualitative interview guide was used on a sample of 41 informants. The main findings are: (1) Different terms are in use; (2) two major changes in naming are observed by the informants: (a) during the 1970s from ‘feeble-minded’ to ‘mental developmental disability’, and (b) after year 2000 from ‘mental developmental disability’ to ‘developmental disability’; (3) professionals are in doubt as to whic…

Predictors of enhancing human physical attractiveness: Data from 93 countries

2022

People across the world and throughout history have gone to great lengths to enhance their physical appearance. Evolutionary psychologists and ethologists have largely attempted to explain this phenomenon via mating preferences and strategies. Here, we test one of the most popular evolutionary hypotheses for beauty-enhancing behaviors, drawn from mating market and parasite stress perspectives, in a large cross-cultural sample. We also test hypotheses drawn from other influential and non-mutually exclusive theoretical frameworks, from biosocial role theory to a cultural media perspective. Survey data from 93,158 human participants across 93 countries provide evidence that behaviors such as a…