Search results for " Phase"

Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma

2002

The p16INK4a gene, localized within chromosome 9p21, has been identified as a cyclin-dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series of 64 untreated patients (median of follow up 53 months) undergoing surgical resection for locally advanced laryngeal squamous-cell carcinomas (LSCCs) has been studied prospectively. Our purpose was to investigate p16 alterations (9p21 allelic loss, hypermethylation and point mutations) and their possible association with clinico-pathological data and flow cytometric variables (DNA-ploidy and S-phase fraction (SPF)…

Lipid and apoprotein composition of HDL in partial or complete CETP deficiency

2012

Hyperalphalipoproteinemia, as observed in patients who are either homozygous or heterozygous for cholesteryl ester transfer protein (CETP) deficiency, has been shown to be associated with striking changes in apolipoprotein size distribution, namely, of high-density lipoprotein (HDL) and HDL-like particles. We compared the effect of varying degrees of CETP activity on the HDL apolipoprotein profile in Caucasian CETP-deficient subjects and following pharmacological decrease in CETP activity, using Size Exclusion Chromatography followed by Reverse Phase Protein Array (SEC RPA). The main HDL-associated apolipoproteins (Apo), i.e. ApoA-I, ApoA-II, ApoC-I, and ApoC-III, co-eluted with the HDL pea…

BIOELECTRICAL PHASE ANGLE ON HOSPITAL ADMISSION AS PREDICTOR OF SHORT- AND MIDDLE-TERM MORTALITY IN ELDERLY MEDICAL PATIENTS.

2013

Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic…

2021

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses, resulting in necrosis of brain parenchyma. Stroke pathogenesis is characterized by neuroinflammation and endothelial dysfunction. Some of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells (microglia, astrocytes and endothelial cells), inflammatory cytokines, and translocation of intercellular nuclear factors. Inflammation in stroke includes all the processes mentioned above, and it consists of either protective or detrimental effects concerning the “polarization” of these processes. This polarization comes out from the intera…

The "Honeymoon Phase" in Children with Type 1 Diabetes Mellitus (T1DM): Frequency, Duration and Predictive Factors at Onset

2012

Abstract: Aim of thè study was: to analyze thè epidemiological features of paediatric T1DM at onset and their relation to remission frequency and duration in thè first year of disease, to assess clinical effìcacy of Glucose Evaluation Trial REMission (GETREM) protocol in terms of induction and maintenance of thè "honeymoon phase" and to evaluate Insulin Dose-Adjusted A1C values at onset [IDAA1C = HbAlc% + (Insulin U/Kg/die x 4)] as a predictor of remission. 181 patients less than 15 years of age were admitted at our Department for T1DM onset and were treated according to GETREM protocol in thè years 2008-2011. The following data were recorded at onset: age, sex, modality of onset according …

Heterogeneous nucleation of colloidal melts under the influence of shearing fields

2004

Large, oriented single crystals may be obtained from shear melts of colloidal particles after nucleation at the container walls. We are here interested in the processes occurring during the initial phase of their formation. Using different microscopic and scattering techniques we here studied highly charged suspensions of spherical particles, dispersed in low salt or deionized water, in single and double wall confinement, during and after cessation of shear. While the equilibrium phase of our colloidal solids is body centred cubic, the shear induced precursors of heterogeneous nuclei consist of wall based, oriented, registered or freely sliding layers with in plane hexagonal symmetry. Cessa…

Analysis of stamping performances of dual phase steels: A multi-objective approach to reduce springback and thinning failure

2009

The industrial interest on light weight components has contributed in the last years to a significant research effort on new materials able to guarantee high mechanical properties, good formability and reasonable costs together with reduced weights when compared to traditional mild steels. Among such materials advanced high strength steels (AHSS) such as transformations induced plasticity (TRIP) and dual phase (DP), and light weight alloys proved their usefulness in stamping of automotive components. As AHSS are concerned, one of the main drawbacks is related to springback occurrence. Many aspects have to be taken into account when springback reduction is investigated: material behavior iss…

First Study on Nihonium (Nh, Element 113) Chemistry at TASCA

2021

Frontiers in Chemistry 9, 753738 (2021). doi:10.3389/fchem.2021.753738

Analysis of the hydrodynamics of a periodically operated trickle-bed reactor—A shock wave velocity

2014

Abstract The relationship describing the shock wave velocity was formulated for the trickle-bed reactor operating at periodically changed feeding the bed with liquid phase. The values of shock wave velocity calculated from derived equations were compared with experimental values obtained for both fast and slow mode of base–pulse periodic liquid feeding and using liquids differing in physicochemical properties. A good agreement between these two sets of values of shock wave velocity was obtained. It has to be emphasized that the relationship (Eq. (26) ) derived in this study enables to estimate the values of the shock wave velocity when only mean values of variables of a process are known.

Incipient damage identification through characteristics of the analytical signal response

2008

The analytical signal is a complex representation of a time domain signal: the real part is the time domain signal itself, while the imaginary part is its Hilbert transform. It has been observed that damage, even at a very low level, yields clearly detectable variations of analytical signal quantities such as phase and instantaneous frequency. This observation can represent a step toward a quick and effective tool to recognize the presence of incipient damage where other frequency-based techniques fail. In this paper a damage identification procedure based on an adimensional functional of the square of the difference between the characteristics of the analytical theoretical and measured sig…