Search results for " Present"
showing 10 items of 566 documents
Panell d'experts: Per on avança en les empreses l'economia del coneixement?
2012
El Projecte ABACO (Observatori de les Activitats basades en el coneixement), una idea de VLC / CAMPUS. València, Internacional Campus of Excellence i l'Ivie, l'objectiu és impulsar la informació, la reflexió i l'anàlisi d'aquestes activitats, amb la finalitat de reconèixer la importància que han assolit a Espanya i avaluar el seu impacte. La jornada organitzada per VLC / CAMPUS té un doble objectiu: analitzar quin està sent l'avanç de l'economia del coneixement a Espanya i, en aquest marc, presentar ABACO.
Panell d'experts: Com contribueixen les institucions d'R + D + I a les ABACO?
2012
El Projecte ABACO (Observatori de les Activitats basades en el coneixement), una idea de VLC / CAMPUS. València, Internacional Campus of Excellence i l'Ivie, l'objectiu és impulsar la informació, la reflexió i l'anàlisi d'aquestes activitats, amb la finalitat de reconèixer la importància que han assolit a Espanya i avaluar el seu impacte. La jornada organitzada per VLC / CAMPUS té un doble objectiu: analitzar quin està sent l'avanç de l'economia del coneixement a Espanya i, en aquest marc, presentar ABACO
Apertura del congrés ABACO
2012
El Projecte ABACO (Observatori de les Activitats Basades en el Coneixement), una idea de VLC / CAMPUS. València, Internacional Campus of Excellence i l'Ivie, l'objectiu és impulsar la informació, la reflexió i l'anàlisi d'aquestes activitats, amb la finalitat de reconèixer la importància que han assolit a Espanya i avaluar el seu impacte. La jornada organitzada per VLC / CAMPUS té un doble objectiu: analitzar quin està sent l'avanç de l'economia del coneixement a Espanya i, en aquest marc, presentar ABACO.
Presentació del Projecte ABACO
2012
El Projecte ABACO (Observatori de les Activitats basades en el coneixement), una idea de VLC / CAMPUS. València, Internacional Campus of Excellence i l'Ivie, l'objectiu és impulsar la informació, la reflexió i l'anàlisi d'aquestes activitats, amb la finalitat de reconèixer la importància que han assolit a Espanya i avaluar el seu impacte. La jornada organitzada per VLC / CAMPUS té un doble objectiu: analitzar quin està sent l'avanç de l'economia del coneixement a Espanya i, en aquest marc, presentar ABACO.
Converting Retirement Benefit into a Life Care Annuity with Graded Benefits: How Costly Would it Actually Be?
2016
This paper deals with life care annuities, i.e. bundled products comprising a life annuity and long-term care insurance. It aims to assess the cost of converting retirement benefit into a life care annuity with graded benefits using a pre-existing public pay-as-you-go pension scheme. With this objective in mind, we present an actuarial method based on array calculus for valuing this type of life care annuity. The health dynamics of the annuitant rely on a reversible illness-death multistate framework. The paper contains a numerical example in which mortality and disability assumptions are based on data from the USA and Australia, although this should be viewed simply as an illustration. In …
Cytomegalovirus Misleads Its Host by Priming of CD8 T Cells Specific for an Epitope Not Presented in Infected Tissues
2003
Cytomegaloviruses (CMVs) code for several proteins that inhibit the presentation of antigenic peptides to CD8 T cells. Although the molecular mechanisms of CMV interference with the major histocompatibility complex class I pathway are long understood, surprisingly little evidence exists to support a role in vivo. Here we document the first example of the presentation of an antigenic peptide being blocked by a CMV immune evasion protein in organs relevant to CMV disease. Although this Db-restricted peptide, which is derived from the antiapoptotic protein M45 of murine CMV (mCMV), is classified as an immunodominant peptide based on response magnitude and long-term memory, adoptive transfer of…
Loss of interferon-gamma inducibility of the MHC class II antigen processing pathway in head and neck cancer: evidence for post-transcriptional as we…
2008
Summary Background Abnormalities of the major histocompatibility complex (MHC) antigens by tumour cells impair the cellular immune response and promote tumour evasion from immune surveillance. So far, studies analysing the MHC class II expression levels in head and neck cancer have been limited. Objectives Therefore, we investigated the constitutive and interferon (IFN)-γ-regulated expression profiles of MHC class II antigen processing machinery (APM) in various head and neck cancer cell lines and also analysed the MHC class II expression in head and neck cancer lesions. Methods Using immunohistochemistry, flow cytometry, and reverse transcriptase-polymerase chain reaction analyses we in…
Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells.
2000
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that can be used for vaccination purposes, to induce a specific T-cell response in vivo against melanoma-associated antigens. We have shown that the sequential use of early-acting hematopoietic growth factors, stem cell factor, IL-3 and IL-6, followed by differentiation with IL-4 and granulocyte-macrophage colony-stimulating factor allows the in vitro generation of large numbers of immature DCs from CD34(+) peripheral blood progenitor cells. Maturation to interdigitating DCs could specifically be induced within 24 hr by addition of TNF-alpha. Here, we report on a phase I clinical vaccination trial in melanoma patients us…
Rapid High Efficiency Sensitization of CD8+ T Cells to Tumor Antigens by Dendritic Cells Leads to Enhanced Functional Avidity and Direct Tumor Recogn…
2003
Abstract Myeloid-origin dendritic cells (DCs) can develop into IL-12-secreting DC1 or non-IL-12-secreting DC2 depending on signals received during maturation. Through rapid culture techniques that prepared either mature, CD83+ DC1 or DC2 from CD14+ monocytes in only 2 days followed by a single 6–7 day DC-T cell coculture, we sensitized normal donor CD8+ T cells to tumor Ags (HER-2/neu, MART-1, and gp100) such that peptide Ag-specific lymphocytes constituted up to 16% of the total CD8+ population. Both DC1 and DC2 could sensitize CD8+ T cells that recognized peptide-pulsed target cells. However, with DC2, a general decoupling was observed between recognition of peptide-pulsed T2 target cells…
Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in…
2013
Background Culture-dependent methods have shown that meconium, the newborn's first intestinal discharge, is not sterile, but the diversity of bacteria present in this material needs to be further characterized by means of more sensitive molecular techniques. Objective Our aims were to characterize molecularly the meconium microbiota in term infants, to assess whether it contributes to the future microbiota of the infants' gastrointestinal tract, and to evaluate how it relates to lifestyle variables and atopy-related conditions. Methods We applied high-throughput pyrosequencing of the 16S rRNA gene to study the meconium microbiota in twenty term newborns from a Spanish birth cohort. For comp…