Search results for " Product"
showing 10 items of 7368 documents
New challenge for social inclusion - marine product processing development of mussel farming in the Baltic sea region
2020
Product recycling opportunities that potentially increase the value of the initial product create interest in creating and developing a field. Seafood is demanded product in the world but creating a higher value of the product the value of it can be increased and in many countries it helped to solve social problems with food provision and employment. Aim of research analysis of area for mollusc farming, and mollusc-processing options to explore opportunities for development of the field. By analysing views of public administrators, entrepreneurs and researchers in selected Baltic Sea Region countries. Based on expert viewpoint (public administrators, entrepreneurs and researchers that parti…
Crisis y creación. Las ambivalentes relaciones germano-españolas en la producción cinematográfica de la primera mitad del siglo veinte
2016
Politisch-soziale Krisenzeiten tragen in besonderem Maße zur Entstehung und Festigung von bestimmten Auto- und Heterostereotypen bei. Diese schlüssige Behauptung kann man anhand der Analyse der verschiedenen politischen Phasen Spaniens im Laufe seiner Geschichte und ihrer Auswirkung auf das erzeugte Fremdenbild nachvollziehen. Das durch den spanischen Unabhängigkeitskrieg (1808-1814) verbreitete stereotypisierte Gedankengut der Romantik wurde in der ersten Hälfte des zwanzigsten Jahrhunderts zu einem Instrument propagandistischer Manipulation, das den Vorbildcharakter des spanischen Alliierten hervorheben sollte. Dieser politische Kunstgriff verfolgte die ideologische Sympathie für das nati…
Experimental Procedures of Accelerated Aging and Evaluation of Effectiveness of Nanostructured Products for the Protection of Volterra (Italy) Panchi…
2022
The aims of the research were to evaluate the effectiveness of the application of nanostructured products on Volterra calcarenite stone and to define the experimental conditions and procedures of accelerated aging tests, able to simulate different degradation on the studied lithotype. The work focused on methods of performing accelerated aging tests in order to simulate different effects of environmental decay involving stone used on a historical site. The rock samples were examined before and after three treatment types: cyclic salt spray chamber, cycles of freezing–thawing and cycles of thermal shock. After each artificial aging cycle, changes in appearance were noted and chemical and phy…
Comparison of different theory models and basis sets in the calculation of 13C NMR chemical shifts of natural products.
2004
The influence of the calculation method in mimicking experimental 13C NMR chemical shifts of 15 low-polarity natural products singularly containing 10–20 carbon atoms was investigated by employing different quantum chemistry approaches and basis sets, both in the preliminary geometry optimizations and in the following single-point 13C GIAO calculations of the NMR chemical shifts. The geometries of the involved species were optimized at the PM3, HF, B3LYP and mPW1PW91 levels whereas the 13C NMR parameters were determined at the HF, B3LYP and mPW1PW91 levels. Different combinations of basis sets were also tested. The consistency and efficiency of the considered combinations of geometry optimi…
Four-Component Relativistic DFT Calculations of C-13 Chemical Shifts of Halogenated Natural Substances
2015
We have calculated the (13) C NMR chemical shifts of a large ensemble of halogenated organic molecules (81 molecules for a total of 250 experimental (13) C NMR data at four different levels of theory), ranging from small rigid organic compounds, used to benchmark the performance of various levels of theory, to natural substances of marine origin with conformational degrees of freedom. Carbon atoms bonded to heavy halogen atoms, particularly bromine and iodine, are known to be rather challenging when it comes to the prediction of their chemical shifts by quantum methods, due to relativistic effects. In this paper, we have applied the state-of-the-art four-component relativistic density funct…
Destroying the Shield of Cancer Stem Cells: Natural Compounds as Promising Players in Cancer Therapy
2022
In a scenario where eco-sustainability and a reduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. The presence of a heterogeneous cancer stem cell (CSC) population within a tumor bulk is related to disease recurrence and therapy resistance. For this reason, CSC targeting presents a promising strategy for hampering cancer recurrence. Increasing evidence shows that NPs can inhibit crucial signaling pathways involved in the maintenance of CSC stemness and sensitize CSCs to standard chemotherapeutic treatments. Moreover, their limited toxici…
Medicinal and aromatic plants in agricultural research, when considering criteria of multifunctionality and sustainability
2022
Over the last twenty years, agriculture has witnessed significant changes in terms of energy requirements, advanced technologies and practices. This is in response to the impacts of crop production on the climate and environment and increasing awareness of the importance of agricultural sustainability through organic farming. Agriculture encompasses complex production systems and certain aspects of multifunctionality and sustainability have become fundamental for these systems. Agricultural activity can provide various functions in agro-ecosystems, such as producing food, managing natural resources, and conserving landscape and plant biodiversity; contributing to the cultural, historical an…
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer
2020
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was subsequently determined to have roles in multiple normal biochemical processes as well as various disease conditions. GSK-3 is sometimes referred to as a moonlighting protein due to the multiple substrates and processes which it controls. Frequently, when GSK-3 phosphorylates proteins, they are targeted for degradation. GSK-3 is often considered a component of the PI3K/PTEN/AKT/GSK-3/mTORC1 pathway as GSK-3 is frequently phosphorylated by AKT which regulates its inactivation. AKT is often active in human cancer a…
Herbal Medications in Endodontics and Its Application—A Review of Literature
2022
Herbal products are gaining popularity in dental and medical practice nowadays due to their biocompatibility, higher antimicrobial activity, antioxidant and anti-inflammatory properties. Herbal medicine has experienced rapid growth in recent years due to its beneficial properties, ease of availability, and lack of side effects. As pathogenic bacteria become more resistant to antibiotics and chemotherapeutic agents, researchers are becoming more interested in alternative products and treatment choices for oral diseases. As a result, natural phytochemicals separated from plants and utilized in traditional medicine are suitable substitutes for synthetic chemicals. The aim of this review articl…
In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides
2012
Withania somnifera (L.) Dunal (Indian ginseng, winter cherry, Solanaceae) is widely used in traditional medicine. Roots are either chewed or used to prepare beverages (aqueous decocts). The major secondary metabolites of Withania somnifera are the withanolides, which are C-28-steroidal lactone triterpenoids. Withania somnifera extracts exert chemopreventive and anticancer activities in vitro and in vivo. The aims of the present in silico study were, firstly, to investigate whether tumor cells develop cross-resistance between standard anticancer drugs and withanolides and, secondly, to elucidate the molecular determinants of sensitivity and resistance of tumor cells towards withanolides. Usi…