Search results for " Program"
showing 10 items of 3075 documents
An unexpected Dimroth rearrangement leading to annelated thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines with potent antitumor activity.
2013
An unusual Dimroth rearrangement occurring in the reaction leading to annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine core allowed the isolation of the linear isomer thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidine. By decorating the linear isomer with the same chains that improved the biological activity of the angular isomers, new annelated thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidines were designed and synthesized. They were selected by the Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI) for the anticancer screening against a panel of 60 human tumor cell lines. The biological results showed that the new derivatives exhibited strong antiproliferative …
New annelated thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines, with potent anticancer activity, designed through VLAK protocol
2012
Drug design was performed through the Virtual Lock-and-Key (VLAK) protocol. This in silico approach allowed to select new annelated thienotriazolopyrimidine derivatives, potentially antitumor drugs. Starting from benzothieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine and Pyrido[3',2':4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine core structures, new derivatives of these nuclei were designed and synthesized. Three of them were selected by the Development Therapeutical Program (DTP) of the National Cancer Institute (NCI) for the anticancer screening against a panel of 60 human tumor cell lines. The biological results showed that the new derivatives exhibited an excellent antiproliferative act…
The role of the committee of the regions (CoR) to implement the Green Deal at the local level: an overview of Italy
2021
<abstract> <p>The contribution focuses on the role of cities in the implementation of the so-called Green Deal, the ambitious program proposed by the European Commission, in accordance with the objectives set by the Paris Agreements, to implement the use of clean energy resources, favour the circular economy, restore biodiversity and reduce pollution. The Plan, which for the seven-year period 2021-2027 has a budget of economic resources of 100 billion Euro, aims to involve in transcalar perspective all territorial and administrative levels of the Member States and thus contribute to the achievement, in 2050, of climate neutrality. The main objective of the work is then to concen…
Demo: Co-simulation of UAVs with INTO-CPS and PVSio-web
2018
This demo shows our ongoing work on the co-simulation of co-operative Unmanned Aerial Vehicles (UAVs). The work is based on the INTO-CPS co-simulation engine, which adopts the widely accepted Functional Mockup Interface (FMI) standard for co-simulation, and the PVSioweb prototyping tool, that extends a system simulator based on the PVS logic language with a web-based graphical interface. Simple scenarios of Quadcopters with assigned different tasks, such as rendez-vous and space coverage, are shown. We assumed a linearized dynamic model for Quadcopters formalized in OpenModelica, and a linearized set of equations for the flight control module written in C language. The co-ordination algorit…
The improvement of quality management system in a porcelain factory
2019
According to SR EN ISO 9000:2015, quality management system can be considered “a set of Policies, Procedures, Processes and resources used to achieve the organization objectives and desired results, by manages the interacting processes, resources required and inter-related parts of the business”. The requirements of a quality management system that need to be implemented by companies in order to produce high quality products and to achieve continual improvement are described in ISO 9001. The aim of this research is to improve the quality management system implemented in a porcelain factory, named S.C. APULUM S.A. The implementation of ISO 9001:2015 in the organization involves monitoring pr…
Heterogeneity in general practitioners’ preferences for quality improvement programs: a choice experiment and policy simulation in France
2016
International audience; Despite increasing popularity, quality improvement programs (QIP) have had modest and variable impacts on enhancing the quality of physician practice. We investigate the heterogeneity of physicians’ preferences as a potential explanation of these mixed results in France, where the national voluntary QIP – the CAPI – has been cancelled due to its unpopularity. We rely on a discrete choice experiment to elicit heterogeneity in physicians’ preferences for the financial and non-financial components of QIP. Using mixed and latent class logit models, results show that the two models should be used in concert to shed light on different aspects of the heterogeneity in prefer…
Aula abierta
2015
ResumenEl objetivo del presente estudio fue analizar el impacto percibido por parte de los alumnos como resultado de su participación en el programa de la Universidad de la Experiencia de la Universidad de La Rioja. La muestra estuvo formada por 83 alumnos de dicho programa. Al grupo de estudiantes se les aplicó un cuestionario diseñado ad hoc para evaluar potenciales resultados a diferentes niveles: general, educativo, social, afectivo, cognitivo, físico y afectividad negativa. Los resultados obtenidos muestran que el impacto del programa trasciende la adquisición de conocimientos, alcanzando otras esferas relevantes de la persona como son la social, la psicológica y la física. Además, los…
Health related quality of life after gastric bypass or intensive lifestyle intervention: a controlled clinical study
2013
Background There is little robust evidence relating to changes in health related quality of life (HRQL) in morbidly obese patients following a multidisciplinary non-surgical weight loss program or laparoscopic Roux-en-Y Gastric Bypass (RYGB). The aim of the present study was to describe and compare changes in five dimensions of HRQL in morbidly obese subjects. In addition, we wanted to assess the clinical relevance of the changes in HRQL between and within these two groups after one year. We hypothesized that RYGB would be associated with larger improvements in HRQL than a part residential intensive lifestyle-intervention program (ILI) with morbidly obese subjects. Methods A total of 139 mo…
Solvent-induced free energy landscape and solute-solvent dynamic coupling in a multielement solute
1999
AbstractMolecular dynamics simulations using a simple multielement model solute with internal degrees of freedom and accounting for solvent-induced interactions to all orders in explicit water are reported. The potential energy landscape of the solute is flat in vacuo. However, the sole untruncated solvent-induced interactions between apolar (hydrophobic) and charged elements generate a rich landscape of potential of mean force exhibiting typical features of protein landscapes. Despite the simplicity of our solute, the depth of minima in this landscape is not far in size from free energies that stabilize protein conformations. Dynamical coupling between configurational switching of the syst…
Distributed construction of quantum fingerprints
2003
Quantum fingerprints are useful quantum encodings introduced by Buhrman, Cleve, Watrous, and de Wolf (Physical Review Letters, Volume 87, Number 16, Article 167902, 2001; quant-ph/0102001) in obtaining an efficient quantum communication protocol. We design a protocol for constructing the fingerprint in a distributed scenario. As an application, this protocol gives rise to a communication protocol more efficient than the best known classical protocol for a communication problem.