Search results for " Programming"
showing 10 items of 1616 documents
Design of the CGAL 3D Spherical Kernel and application to arrangements of circles on a sphere
2009
AbstractThis paper presents a cgal kernel for algorithms manipulating 3D spheres, circles, and circular arcs. The paper makes three contributions. First, the mathematics underlying two non-trivial predicates are presented. Second, the design of the kernel concept is developed, and the connexion between the mathematics and this design is established. In particular, we show how two different frameworks can be combined: one for the general setting, and one dedicated to the case where all the objects handled lie on a reference sphere. Finally, an assessment about the efficacy of the 3D Spherical Kernel is made through the calculation of the exact arrangement of circles on a sphere. On average w…
On the Parameterization of Cartesian Genetic Programming
2020
In this work, we present a detailed analysis of Cartesian Genetic Programming (CGP) parametrization of the selection scheme ($\mu+\lambda$), and the levels back parameter l. We also investigate CGP’s mutation operator by decomposing it into a self-recombination, node function mutation, and inactive gene randomization operators. We perform experiments in the Boolean and symbolic regression domains with which we contribute to the knowledge about efficient parametrization of two essential parameters of CGP and the mutation operator.
Correspondence to Sand et al. “Critical Reappraisal of a Catechol-O-Methyltransferase Transversion Variant in Schizophrenia”
2010
DNASE1L3 Deficiency, New Phenotypes and Evidence for a Transient Type I Interferon Signaling
2021
Introduction: Deoxyribonuclease 1 like 3 (DNASE1L3) is a secreted enzyme that has been shown to digest the extracellular chromatin derived from apoptotic bodies, and DNASE1L3 pathogenic variants have been associated to a lupus phenotype. It is unclear whether interferon signaling is sustained in DNASE1L3 deficiency in humans. Objectives: Here, we report on four patients with pathogenic variations in DNASE1L3, including 2 previously undescribed causal variants, and expand the phenotype from SLE to vasculitis with gut involvement. To explore whether or not the interferon cascade was strongly and sustainably induced, Interferon stimulated genes (ISGs) expression was assessed for each patient. …
Association between previously identified disease loci at Chr 21q22 and MHC and UC in Italian population.
2009
Human blastocysts derived from monopronuclear zygotes: a biological model for the study of ploidy, euploidy, topography and heteroparental inheritance
2019
Rapid evolving RNA gene HAR1A and schizophrenia
2008
Developing the "next generation" of genetic association databases for complex diseases
2012
Tens of thousands of genetic association studies investigating the influence of common polymorphisms on disease susceptibility have been published to date. These include similar to 1,000 genome-wide association studies (GWAS). This vast amount of data in the field of complex genetics is becoming increasingly difficult to follow and interpret. It can be expected that the situation will become even more complex with the advent of association projects using next-generation technologies. One of the aims of the Human Variome Project is to concatenate such data in meaningful ways, for example, within the context of publicly available field synopses. Here, we present various examples of online gen…
Summaries of presentations during the sixth Workshop of the International Association of Phytoplankton Ecology and Taxonomy, Mondsee, Austria, 15–25 …
1987
Towards the integration and development of a cross-European research network and infrastructure: the DEterminants of DIet and Physical ACtivity (DEDI…
2014
To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address major societal challenges that no Member State is capable of resolving independently. Setting up a Joint Programming Initiative (JPI) should also contribute to avoiding unnecessary overlap and repetition of research, and enable and enhance the development and use of standardised research methods, procedures and data management. The Determinants of Diet …