Search results for " Prostate"

showing 10 items of 177 documents

Sexual dysfunctions after transurethral resection of the prostate (TURP): evidence from a retrospective study on 264 patients

2015

Objectives: Benign prostatic hyperplasia (BPH) and sexual dysfunctions are diseases with a high prevalence in aged men. Several studies have found a link between BPH and LUTS resulting from deterioration in sexual function in men aged 50 years and older for whom TURP is considered the gold standard. The impact of TURP on sexual functions still remain uncertain, nor is it clear what pathophysiological mechanism underlying the emergence of new episodes of Erectile Dysfunction (ED) following TURP in patients with normal sexual function before surgery, while retrograde ejaculation and ejaculate volume reduction represent a clear side effect; derived from BPH treatment. The aim of this study was…

MaleRetrograde ejaculationmedicine.medical_specialtyLongitudinal studyUrologymedicine.medical_treatmentProstatic Hyperplasialcsh:RC870-923urologic and male genital diseasesPreoperative careSettore MED/24 - UrologiaErectile DysfunctionErectile Dysfunction (ED)Surveys and QuestionnairesInternal medicinePreoperative CaremedicineHumansInternational index of erectile function (IIEF)Longitudinal StudiesSicilyTransurethral resection of the prostate (TURP)AgedRetrospective StudiesTransurethral resection of the prostateAged 80 and overPostoperative CareLibidoBenign prostatic hyperplasiabusiness.industryBenign prostatic hyperplasia (BPH)Low urinary tract symptoms (LUTS).Transurethral Resection of ProstateTransurethral resection of the prostateRetrospective cohort studyMiddle Agedlcsh:Diseases of the genitourinary system. Urologymedicine.diseaseInternational index of erectile functionLow urinary tract symptomsSurgeryErectile dysfunctionSexual functionbusinessArchivio Italiano di Urologia e Andrologia
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PSA reduction (after antibiotics) permits to avoid or postpone prostate biopsy in selected patients

2007

Microscopic foci of prostatitis may induce prostate-specific antigen (PSA) increase. PSA reduction after antibiotics might identify those patients in whom biopsy can be avoided. Ninety-nine patients received ciprofloxacin for 3 weeks, of whom 59 showed PSA reduction. Histology detected small foci of prostatitis in 65% of cases. Carcinoma was found in 40 and 20.3% of patients with unchanged or decreased PSA, respectively (P=0.03). No cancer was detected if PSA decreased below 4 ng/ml or more than 70%. Biopsy can be postponed, with a low risk of missing a cancer, if PSA decreases more than 70% or below 4 ng/ml.

MaleRiskCancer Researchmedicine.medical_specialtyTime FactorsProstate biopsymedicine.drug_classUrologyAntibioticsUrologyProstatitisUnnecessary Proceduresurologic and male genital diseasesSettore MED/24 - UrologiaDiagnosis DifferentialProstate cancerCiprofloxacinBiopsyCarcinomaHumansMedicineUltrasonography InterventionalAgedAged 80 and overPalpationmedicine.diagnostic_testbusiness.industryPatient SelectionBiopsy NeedleProstateProstatic NeoplasmsCancerHistologyOrgan SizeMiddle AgedProstate-Specific Antigenmedicine.diseaseAnti-Bacterial AgentsProstatitisOncologybusinessprostate-specific antigen (PSA) prostatitis prostate carcinomaFollow-Up Studies
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Use of Solovov-Badenoch principle in treating severe and recurrent vesico-urethral anastomosis stricture after radical retropubic prostatectomy: tech…

2012

What's known on the subject? and What does the study add? Many different approaches have been used to treat bladder neck strictures and urinary incontinence after radical prostatectomy in the past. Most techniques are highly invasive and carry a high risk of complications. The present study describes the use of the Solovov-Badenoch 'pull-through urethroplasty' as well as artificial urinary sphincter implantation.• To report our experience in the management of patients with combined urinary incontinence and stricture after radical prostatectomy with a two-step approach: urethroplasty with a 'pull-through' technique after the Solovov-Badenoch principle; and artificial urinary sphincter (AUS) …

MaleTime FactorsVesico-urethral anastomosiTime FactorUrologyUrinary BladderUrinary incontinenceBladder neck contractureSeverity of Illness IndexFollow-Up StudiePostoperative ComplicationsUrethraRetrospective StudieRecurrenceHumansTreatment FailureAgedRetrospective StudiesProstatectomyAnastomosis SurgicalMiddle AgedRadical prostatectomyUrinary Bladder Neck ObstructionTreatment OutcomeArtificialUrinary sphincterPostoperative ComplicationStrictureHumanFollow-Up Studies
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The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer.

2018

Prostate-specific membrane antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (CaP). PSMA-expression correlates with higher serum levels of prostate-specific antigen (PSA) and a higher Gleason score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). This article reviews the literature pertaining to various new imaging technologies for the management of CaP. PSMA positron emission tomography/computed tomography appears to be an exce…

MaleUrology030232 urology & nephrologyComputed tomographyGallium Radioisotopesurologic and male genital diseasesMultimodal ImagingManagement of prostate cancer03 medical and health sciences0302 clinical medicinePositron Emission Tomography Computed TomographymedicineOrganometallic CompoundsHumansGallium IsotopesMembrane antigenSalvage TherapyPET-CTMembrane Glycoproteinsmedicine.diagnostic_testbusiness.industry68ga psmaProstatic NeoplasmsMagnetic resonance imagingProstate carcinomaProstate-Specific AntigenMagnetic Resonance ImagingPositron emission tomography030220 oncology & carcinogenesisPositron-Emission TomographyNeoplasm Recurrence LocalRadiopharmaceuticalsbusinessNuclear medicineUrology
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Multicenter Multireader Evaluation of an Artificial Intelligence-Based Attention Mapping System for the Detection of Prostate Cancer With Multiparame…

2020

OBJECTIVE. The purpose of this study was to evaluate in a multicenter dataset the performance of an artificial intelligence (AI) detection system with attention mapping compared with multiparametric MRI (mpMRI) interpretation in the detection of prostate cancer. MATERIALS AND METHODS. MRI examinations from five institutions were included in this study and were evaluated by nine readers. In the first round, readers evaluated mpMRI studies using the Prostate Imaging Reporting and Data System version 2. After 4 weeks, images were again presented to readers along with the AI-based detection system output. Readers accepted or rejected lesions within four AI-generated attention map boxes. Additio…

MaleUrologyAdenocarcinomaSensitivity and SpecificityArticle030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancerRandom Allocation0302 clinical medicineLaparoscopicProstateArtificial IntelligenceStatistical significanceMedicineHumansAttentionRadiology Nuclear Medicine and imagingDiagnosis Computer-AssistedMultiparametric Magnetic Resonance ImagingAgedRetrospective StudiesObserver VariationProstate cancerbusiness.industryartificial intelligence; laparoscopic; MRI; multiparametric; prostate cancer; radical prostatectomy; robot-assistedSignificant differenceCancerMultiparametric MRIProstatic NeoplasmsGeneral MedicineRobot-assistedMiddle Agedmedicine.diseaseRadical prostatectomymedicine.anatomical_structure030220 oncology & carcinogenesisMapping systemMultiparametricArtificial intelligencebusinessAlgorithmsMriAJR. American journal of roentgenology
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Metronomic oral cyclophosphamide prednisolone chemotherapy is an effective treatment for metastatic hormone-refractory prostate cancer after docetaxe…

2010

There is currently no standard of treatment for patients with hormone refractory prostate cancer (HRPC) after failure of docetaxel-based chemotherapy. The purpose of this study was to assess the anticancer activity and tolerance of metronomic cyclophosphamide prednisolone combination in this setting.From 2005 to 2010, patients with HRPC who failed at least docetaxel-based chemotherapy were proposed metronomic cyclophosphamide-prednisolone regimen, and were prospectively registered. Twenty-three patients received 50 mg cyclophosphamide and 10 mg prednisolone per os daily until disease progression. Treatment tolerance and efficacy on PSA decrease and pain were studied.Metronomic cyclophospham…

Male[SDV.IMM] Life Sciences [q-bio]/ImmunologyMESH : Antineoplastic Combined Chemotherapy ProtocolsMESH: Treatment FailurePrednisoloneMESH : MaleMESH : PrednisoloneMESH: TaxoidsMESH : AgedMESH : Prospective StudiesDocetaxelMESH : Treatment OutcomeMESH : Treatment FailureMESH: Aged 80 and overAntineoplastic Combined Chemotherapy ProtocolsHumans[ SDV.IMM ] Life Sciences [q-bio]/ImmunologyMESH : Middle AgedProspective StudiesTreatment FailureMESH : Prostate-Specific AntigenMESH : Aged 80 and overMESH : TaxoidsCyclophosphamideMESH : Cyclophosphamidehealth care economics and organizationsAgedMESH: Treatment OutcomeAged 80 and overMESH: AgedMESH: HumansMESH: Middle AgedMESH : HumansProstatic NeoplasmsMESH: CyclophosphamideMiddle AgedProstate-Specific AntigenMESH: MaleMESH: Prospective StudiesMESH: Prostate-Specific AntigenMESH: Antineoplastic Combined Chemotherapy ProtocolsTreatment OutcomeMESH: Prostatic Neoplasms[SDV.IMM]Life Sciences [q-bio]/ImmunologyTaxoidsMESH: PrednisoloneMESH : Prostatic Neoplasms
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Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

2017

Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012. Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n = 88) and 2.2 years in those treated with zoledronate (n = 218). Multiv…

MalebisphosphonateTime Factorsmedicine.medical_treatmentOsteoporosis0302 clinical medicineRisk Factors80 and overosteoporosijaw osteonecrosiAged 80 and overBone Density Conservation AgentsDiphosphonatesjaw osteonecrosisjaw osteonecrosis bisphosphonates breast cancer multiple myeloma prostate cance osteoporosisIncidenceIncidence (epidemiology)Otorhinolaryngology2734 Pathology and Forensic MedicineMiddle Agedprostate cancermultiple myeloma030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleAdultmedicine.medical_specialty2734Drug Administration SchedulePathology and Forensic Medicine03 medical and health sciencesbreast cancerbisphosphonates; breast cancer; jaw osteonecrosis; multiple myeloma; osteoporosis; prostate cancer; Adult; Aged; Aged 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cross-Sectional Studies; Diphosphonates; Drug Administration Schedule; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Otorhinolaryngology; 2734; Pathology and Forensic Medicine; Dentistry (all)Internal medicinemedicineHumansBisphosphonates; Breast cancer; Jaw osteonecrosis; Multiple myeloma; Osteoporosis; Prostate cancer; Otorhinolaryngology2734 Pathology and Forensic Medicine; Dentistry (all)prostate canceAdverse effectGeneral DentistrybisphosphonatesAgedProportional Hazards ModelsRetrospective StudiesBisphosphonate-associated osteonecrosis of the jawbusiness.industryProportional hazards modelRetrospective cohort study030206 dentistryBisphosphonatemedicine.diseaseosteoporosisSurgeryCross-Sectional StudiesOtorhinolaryngologyMultivariate AnalysisDentistry (all)businessOsteonecrosis of the jaw
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Brachytherapy organ dose estimation using Monte Carlo simulations of realistic patient models

2018

Radiation Therapy Planning Systems (RTPS) currently used in hospitals contain algorithms based on deterministic simplifications that do not properly consider electrons lateral transport in the areas where there are changes of density, and as a result, erroneous dose predictions could be produced. According to this, the present work proposes the use of Monte Carlo method in brachytherapy planning systems, which could affect positively on the radiotherapy treatment planning, since it provides results that are more accurate and takes into account the in homogeneities density variations. This paper presents a Monte Carlo (MC) simulation of a brachytherapy prostate treatment with I-125 seeds, us…

Malemedicine.diagnostic_testComputer scienceRadiotherapy Planning Computer-Assistedmedicine.medical_treatmentBrachytherapyMonte Carlo methodBrachytherapyRadiotherapy DosageComputed tomographyRadiotherapy treatment planningBrachytherapy prostateIodine RadioisotopesDose estimationmedicineHumansSegmentationRadiation treatment planningMonte Carlo MethodAlgorithmAlgorithms2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
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Initial Experience with Radical Prostatectomy Following Holmium Laser Enucleation of the Prostate

2021

Background: Although an increasing number of prostate cancer (PCa) patients received holmium laser enucleation of the prostate (HoLEP) previously for benign prostatic obstruction (BPO), there is still no evidence regarding the outcomes of radical prostatectomy (RP) in this setting. Objective: To assess functional and oncological results of RP in PCa patients who received HoLEP for BPO previously in a contemporary multi-institutional cohort. Design, setting, and participants: A total of 95 patients who underwent RP between 2011 and 2019 and had a history of HoLEP were identified in two institutions. Functional as well as oncological follow-up was prospectively assessed and retrospectively an…

Malemedicine.medical_specialtyHolmium laser enucleation of the prostate; Localized prostate cancer; Patient-reported outcomes; Radical prostatectomy; Urinary continenceUrologymedicine.medical_treatmentEnucleation030232 urology & nephrologyUrologyProstatic HyperplasiaUrinary incontinenceLasers Solid-State03 medical and health sciencesBladder outlet obstructionProstate cancerHolmium0302 clinical medicineErectile DysfunctionmedicineHumansRetrospective StudiesProstatectomyLocalized prostate cancerPatient-reported outcomesProstatectomybusiness.industryHazard ratioProstateUrinary continenceOdds ratiomedicine.diseaseRadical prostatectomyHolmium laser enucleation of the prostate030220 oncology & carcinogenesisPropensity score matchingmedicine.symptombusiness
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Radiomics analysis of 18F-Choline PET/CT in the prediction of disease outcome in high-risk prostate cancer: an explorative study on machine learning …

2021

Objective: The aim of this study was (1) to investigate the application of texture analysis of choline PET/CT images in prostate cancer (PCa) patients and (2) to propose a machine-learning radiomics model able to select PET features predictive of disease progression in PCa patients with a same high-risk class at restaging. Material and methods: Ninety-four high-risk PCa patients who underwent restaging Cho-PET/CT were analyzed. Follow-up data were recorded for a minimum of 13 months after the PET/CT scan. PET images were imported in LIFEx toolbox to extract 51 features from each lesion. A statistical system based on correlation matrix and point-biserial-correlation coefficient has been impl…

Malemedicine.medical_specialtyMachine learningcomputer.software_genre030218 nuclear medicine & medical imagingCholineCorrelationMachine Learning03 medical and health sciences0302 clinical medicineArtificial IntelligencePositron Emission Tomography Computed TomographymedicineHumansRadiology Nuclear Medicine and imagingCholine; Machine learning; Positron emission tomography computed tomography; Prostate cancer; Radiomics.Prospective StudiesEntropy (energy dispersal)Prospective cohort studySurvival analysisPET-CTbusiness.industryProstatic NeoplasmsGeneral MedicineLinear discriminant analysismedicine.diseasePrimary tumorFeature (computer vision)030220 oncology & carcinogenesisRadiologyArtificial intelligenceNeoplasm Recurrence LocalbusinesscomputerMachine learning Positron emission tomography computed tomography Prostate cancer Radiomics Artificial Intelligence
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