Search results for " Pt"
showing 10 items of 136 documents
Karyological data of some plant species native to South Italy
2019
The somatic chromosome number, karyotype morphology, geographical distribution and ecology of five plant species from the indigenous flora of southern Italy and Sicily are presented. The study includes in particular four species of Allium subgen. Allium (Allium agrigentinum, A. apulum, A. diomedeum, A. chamaespathum), Ptilostemon greuteri and Salvia ceratophylloides. Five out six of these species are strict endemics and all of them are very rare and differently threatened based on the IUCN criteria. Karyotype microphotographs for all taxa are provided and their karyotype morphology is discussed.
On the presence, distribution and conservation status of Lycopodium lagopus (Lycopodiaceae) in Italy
2014
During our work on the Lycopodiaceae account for the upcoming Flora Critica d’Italia (1, 2), we assessed and accepted the presence in Italy of Lycopodium lagopus (Laest. ex Hartm.) Zinserl. ex Kuzen. = L. clavatum subsp. monostachyon (Grev. & Hook.) Selander (2). Already reported by Fiori (3) as L. clavatum f. monostachyum Desv., its presence in Italy was more recently confirmed by Tribsch & Schönswetter (4) and accepted in some subsequent regional works (e.g. 5, 6), but the taxon is not recognized as distinct in the last national checklist of vascular plants (7). Lycopodium lagopus has an arctic-alpine distribution in America and Eurasia (8, 9). Initially described as a variety of L. clava…
Isoetaceae (versione 1.0)
2015
Contributo alla flora critica d'Italia: i generi della famiglia Lycopodiaceae
2012
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene.
2011
Background Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). Approximately 10% (worldwide) of patients have in-frame nonsense mutations (UAA, UAG or UGA class I mutations) in the CF trans-membrane regulator (CFTR) gene that result in premature stop codons (PTCs) in the messenger RNA (mRNA) generating truncated CFTR protein responsible for a severe CF phenotype. Pharmacological approaches have been proposed to directly overcome PTCs. Ataluren (PTC124) a small molecule that mimics the activity of aminoglycosides has been suggested to allow PTCs readthrough and to partially restore the protein function. However, des…
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X )
2013
Obiettivi specifici: Le mutazioni nonsenso (mutazioni STOP), un difetto genetico frequente negli individui affetti da Fibrosi Cistica (CF), causano la sintesi di proteine CFTR tronche e non funzionanti che sono associate ad un fenotipo più severo della CF (McKone EF. et al., Chest 2006). L’obiettivo del nostro studio è stato quello di disegnare derivati dell’Ataluren (PTC124), una ‘small molecule’ a cui è stata attribuita attività readthrough, e valutarne l’attività su tre differenti sistemi modello sperimentali contenenti codoni di STOP prematuri (UGA, UAG, UAA). Materiali e metodi: Sono state sintetizzate 24 molecole derivate dal PTC124 e analizzate mediante tecniche spettroscopiche per v…
COMBINING TRANSLATION READTHROUGH INDUCING DRUGS AND NONSENSE MEDIATED DECAY PATWHAY INHIBITION TO THE CFTR RESCUE IN CYSTIC FIBROSIS CELL MODEL SYST…
2021
Nonsense mutations affect 10% of patients with cystic fibrosis and produce a premature termination codon in CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) mRNA causing early termination of translation and leading to lack of CFTR function. A potential therapy for nonsense mutations provides the use of small molecules able to overcome the premature stop codon (PTC) by a readthrough mechanism that lead to synthesis a complete CFTR protein. Despite the good results obtained from this approach, TRIDs efficiency is considerably reduced by the poor amount of target transcript, that is the mRNA containing the PTC. The readthrough, indeed, does not occur on the totality of target transcr…
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS.
2012
Background Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). Approximately 10% (worldwide) of patients have in-frame nonsense mutations (UAA, UAG or UGA class I mutations) in the CF trans-membrane regulator (CFTR) gene that result in premature stop codons (PTCs) in the messenger RNA (mRNA) generating truncated CFTR protein responsible for a severe CF phenotype. Pharmacological approaches have been proposed to directly overcome PTCs. Ataluren (PTC124) a small molecule that mimics the activity of aminoglycosides has been suggested to allow PTCs readthrough and to partially restore the protein function. However, des…