Search results for " RAF"

Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells.

2011

Though most of the studies have focused on the effects of free fatty acids on T-cell activation, fatty acids incorporated into plasma membrane phospholipids may also affect cell signaling via diacylglycerol (DAG), generally produced by phospholipid hydrolysis. In the present study, we have synthesized a DAG-containing oleic acid and studied its implication in the modulation of calcium signaling in human Jurkat T-cells. 1-palmitoyl-2-oleoyl-sn-glycerol (POG) induced a dose-dependent increase in [Ca(2+)](i). This effect was due to the presence of oleic acid at the sn-2 position as no differences were observed between POG and 1-stearoly-2-oleoyl-sn-glycerol (SOG). However, the substitution of …

Las dificultades de los futuros maestros ante la LIJ: el ejemplo de Alfanhuí

2014

Ilustración: "Setting eyes in sleeping dolls". Lewis Hine, U.S. National Archives

Lipids of the Plant Plasma Membrane

2010

The plasma membrane (PM) is arguably the most diverse membrane of the plant cell. Furthermore, the protein and lipid composition of the PM varies with cell type, developmental stage, and environment. Physical properties of lipids and associate proteins allow the formation of a barrier that is selectively permeable to macromolecules and solutes. As the plasma membrane delineates the interface between the cell and the environment, it is the primary part of signal recognition and transduction into intracellular responses for nutritional uptake/distribution, environmental responses, and developmental signaling. Many essential PM functions are carried out by proteinaceous components. However, PM…

Cine y Educación

2013

Hacienda y Monarquía: a prop-osito del libro de Rafael Torres Sánchez, La llave de todos los tesoros. La Tesorería General de Carlos III

2017

Alteration of the YY1/RKIP ratio is a frequent event in hepatocellular carcinoma

2009

Differential inclusions involving normal cones of nonregular sets in Hilbert spaces

2017

This thesis is dedicated to the study of differential inclusions involving normal cones of nonregular sets in Hilbert spaces. In particular, we are interested in the sweeping process and its variants. The sweeping process is a constrained differential inclusion involving normal cones which appears naturally in several applications such as elastoplasticity, electrical circuits, hysteresis, crowd motion, etc.This work is divided conceptually in three parts: Study of positively alpha-far sets, existence results for differential inclusions involving normal cones and characterizations of Lyapunov pairs for the sweeping process. In the first part (Chapter 2), we investigate the class of positivel…

The significance of dropstones in a tropical lacustrine setting, eastern Cameros Basin (Late Jurassic–Early Cretaceous, Spain)

2004

International audience; Outsized clasts (mainly white quartzite pebbles) are found in carbonate deposits of the Enciso Group exposed on the northern border of the Cameros rift basin (Late Jurassic – Early Cretaceous, northern Spain). In the Arnedillo section, all the stones are enclosed in micrite, which was assumed deposited in littoral to open lacustrine environments, with minor inputs of deltaic sandstones. The clasts are found in fine-grained lacustrine sediments either as isolated stones or as loosely packed elongated clusters occasionally associated with quartz sands and gravels. The mean size of the clasts is 40 mm (range: 3 – 100 mm); they are polished, well-rounded, and lack any fa…

LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly.

2012

International audience; Cholesterol is a fundamental molecule for life. Located in the cell membrane, this sterol participates to the cell signaling of growth factors. Inside the cell it can be converted in hormones such as androgens or modulate the immune response. Such important functions could not be solely dependent of external supply by diet hence de novo synthesis could occur from acetate in almost all mammalian cells. If a deficiency in cholesterol sourcing leads to development troubles, overstocking has been associated to various diseases such as atherosclerosis and cancers. Cholesterol homeostasis should thus be tightly regulated at the uptake, de novo synthesis, storage and export…

Rôle de la Dynamique Membranaire dans la Mise en Place des Mécanismes de Défense chez le Tabac

2011

Cryptogein, a protein secreted by the oomycete Phytophthora cryptogea, induces defense mechanisms in tobacco. Several proteins involved in the associated signaling pathway were identified and localized on the plasma membrane (PM). A fraction resistant to solubilization by detergent named DIMs for Detergent Insoluble Membranes, enriched in sterols an sphigolipids had been isolated from tobacco PM. It was proved to contain proteins previously identified as actors of the signaling cascade triggered by cryptogein. In animal cells, the dynamic association of proteins to sterol and sphingolipid rich microdomains under the influence of a biological stimulus plays an essential role in the regulatio…