Search results for " RAF"
showing 10 items of 142 documents
Les radeaux membranaires et la signalisation végétale
2016
Face à une fluctuation des paramètres de son milieu ambiant ou à une agression biotique, la cellule végétale met en place une réponse adaptative dont les étapes les plus précoces sont la reconnaissance précise et rapide du stress, capable d’induire le développement d’une cascade de signalisation appropriée. Certains des acteurs de ces voies sont localisés sur la membrane plasmique (MP). En fonction de l’espèce, l’état physiologique… d’une cellule, on trouve au sein de sa MP des lipides, des protéines et des oses de structures et en concentrations variables. Chez les cellules de tabac, par exemple, on compte environ 50 lipides pour une protéine.Bien que moins nombreuses, les protéines ont po…
Plant lipid rafts : from proteic composition to physiological roles
2007
International audience; A large body of evidence supports the existence, in membrane from animal and yeast cells, of functional microdomains playing important roles in protein sorting, signal transduction, or infection by pathogens (1). We demonstrated the presence, in plants, of detergent resistant fractions isolated from plasma membrane, with a lipidic composition similar to animal microdomains (2). Electrophoresis experiments indicated that these fractions were able to recruit a specific set of plasma membrane proteins and exclude others. We used mass spectrometry to give an extensive description of a tobacco plasma membrane microdomains. This led to the identification of 145 proteins wh…
Le camere dello scirocco: archetipi bioclimatici della Palermo antica
2014
"Scendesi più in basso a man destra vi è una grotta seu camera di scirocco con fontana in mezzo e tutto un giro di mattoni di Valenza e più sopra un lavoro di crocchiole con diversi animali per buttar l’acqua". Queste parole di un atto notarile del 1691 fanno, per la prima volta, riferimento alla 'camera dello scirocco’, singolare esempio di archetipo per il raffrescamento passivo e parte di un inestimabile patrimonio, eredità di secoli di storia e del succedersi di popoli che hanno fatto di Palermo una città d'arte e cultura. Strutture ipogee che, insieme ad altri capolavori di ingegneria presenti nel sottosuolo palermitano, testimoniano quanto le potenzialità dell'ingegno umano siano in g…
Advances in Targeting Signal Transduction Pathways
2012
// James A. McCubrey 1 , Linda S. Steelman 1 , William H. Chappell 1 , Lin Sun 1,2 , Nicole M. Davis 1 , Stephen L. Abrams 1 , Richard A. Franklin 1 , Lucio Cocco 3 , Camilla Evangelisti 4 , Francesca Chiarini 4 , Alberto M. Martelli 3,4 , Massimo Libra 5 , Saverio Candido 5 , Giovanni Ligresti 5 , Grazia Malaponte 5 , Maria C. Mazzarino 5 , Paolo Fagone 5 , Marco Donia 5 , Ferdinando Nicoletti 5 , Jerry Polesel 6 , Renato Talamini 6 , Jorg Basecke 7 , Sanja Mijatovic 8 , Danijela Maksimovic-Ivanic 8 , Michele Milella 9 , Agostino Tafuri 10 , Joanna Dulinska-Litewka 11 , Piotr Laidler 11 , Antonio B. D’Assoro 12 , Lyudmyla Drobot 13 , Kazuo Umezawa 14 , Giuseppe Montalto 15 , Melchiorre Cer…
Hsp60 from cancer cells can reach near and distant targets: A proposal for a multistage pathway
2011
Cancer cells have means to influence other cells in their vicinity and distant, and in this signal-delivering mechanisms the chaperonin Hsp60 plays a role, which is currently being recognized as potentially crucial for the growth and dissemination of at least certain types of tumors. In order to arrive at its destination, Hsp60, a typical resident of mitochondria in normal and tumor cells, leaves the organelle and reaches the blood. In the latter, Hsp60 can travel and arrive at targets situated far away from its origin. The details of the route followed by Hsp60 and their molecular mechanisms have not yet been fully elucidated. We investigated Hsp60 levels and secretion in normal and tumor …
Regulatory activity of polyunsaturated fatty acids in T-cell signaling.
2009
n-3 Polyunsaturated fatty acids (PUFA) are considered to be authentic immunosuppressors and appear to exert beneficial effects with respect to certain immune-mediated diseases. In addition to promoting T-helper 1 (Th1) cell to T-helper 2 (Th2) cell effector T-cell differentiation, n-3 PUFA may also exert anti-inflammatory actions by inducing apoptosis in Th1 cells. With respect to mechanisms of action, effects range from the modulation of membrane receptors to gene transcription via perturbation of a number of second messenger cascades. In this review, the putative targets of anti-inflammatory n-3 PUFA, activated during early and late events of T-cell activation will be discussed. Studies h…
Induction of Apoptosis and Chemosensitization by the Histone Deacetylase Inhibitor Trichostatin in Hepatocellular Carcinoma Cells: Molecular Analysis…
2011
The mRNA and protein levels of RKIP are reduced and those of YY1 increased in clinical HCC. Loss, mutation, or promoter hypermethylation of the RKIP gene may not account for the downregulation of RKIP in HCC. Histone deacetylation can silence gene expression and play a significant role in hepatocarcinogenesis. The histone deacetylase inhibitor (HDACI) trichostatin induced cell growth inhibition and proapoptotic effects in HA22T/VGH and HepG2 HCC cells; it also exhibited synergy with doxorubicin. Treatment with trichostatin caused histone hyperacetylation and down- or upregulated expression of different genes (such as β-catenin, cyclin D1, hTERT, XIAP, and IL-6). These changes might, at leas…
Rakkautta ja sotaa Apuliassa: Eurooppa
2019
Kirja-arvostelu teoksesta Rafel Nadas Farreras: Palmisanon kirous. Suom. Satu Ekman (katalaanin kielestä), Bazar 2019, 381 s. nonPeerReviewed
Role of persistent CMV infection in configuring T cell immunity in the elderly
2007
Abstract Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have b…
De la tardor medieval al Renaixement: aspectes d'una gran mutació sociolingüística i cultural a través dels Viciana
2003
Review and contextualisation of biographical, bibliographical, linguistic and ideological facets of Martí de Viciana el Vell (the elder) and his grandson Rafael Martí de Viciana (with special attention to linguistic attitude). By contrasting them, it serves to throw into relief the great cultural and sociolinguistic mutation in the heart of the classes dominating the kingdom of Valencia at the end of the 15th century and beginning of the 16th, caused by important political and social changes.