Search results for " RAP"

Patterns of weight cycling in youth Olympic combat sports: a systematic review

2022

Abstract Background Patterns of weight cycling in adult combat sports have been extensively studied, yet data on this matter in youth combat athletes is rather scarce. Methods PubMed, EBSCOhost and Web of Science were used to retrieve relevant data. Eligible studies had to record the methods used to elicit rapid weight loss (RWL) and/or record the oscillations in bodyweight during the RWL phase. Only studies conducted in the context of an official competition were considered for inclusion in the present review. Results RWL is highly prevalent in children and adolescent combat athletes, ranging from 25 to 94% depending on the type of combat sport, age and level of competition. These athletes…

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

2012

Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family and has diverse roles. NGAL can stabilize matrix metalloproteinase-9 from autodegradation. NGAL is considered as a siderocalin that is important in the transport of iron. NGAL expression has also been associated with certain neoplasias and is implicated in the metastasis of breast cancer. In a previous study, we examined whether ectopic NGAL expression would alter the sensitivity of breast epithelial, breast and colorectal cancer cells to the effects of the chemotherapeutic drug doxorubicin. While abundant NGAL expression was detected in all the cells infected with a retrovirus encoding NGAL, t…

Binder design of high RAP content hot and warm asphalt mixture wearing courses

2015

Reclaimed Asphalt Pavement (RAP) has shown great potential for being used in the construction or maintenance of roads. However, RAP is usually downgraded to lower pavement layers and the percentage of RAP used in wearing courses is still moderate (≤30%). The research and results contained in this paper focus on the definition of binder recipes aimed at increasing the percentage of RAP in hot and warm mix asphalt wearing courses. A review of current internationally used blend design methodologies is presented followed by case studies aimed at defining binder recipes for high RAP content asphalt mixture wearing courses to be further used for mix design and production in asphalt plants. Binder…

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

2017

Eukaryotic cell cycle progression through G(1)-S is driven by hormonal and growth-related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway. In yeast, inactivation of TORC1 restricts G(1)-S transition due to the rapid clearance of G(1) cyclins (Cln) and the stabilization of the B-type cyclin (Clb) cyclin-dependent kinase (CDK) inhibitor Sic1. The latter mechanism remains mysterious but requires the phosphorylation of Sic1-Thr(173) by Mpk1 and inactivation of the Sic1-pThr(173)-targeting phosphatase (PP2A(Cdc55)) through greatwall kinase-activated endosulfines. Here we show that the Sic1-pThr(173) residue serves as a specific docking site for the CDK phospho-a…

TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

2015

The target of rapamycin complex 1 (TORC1) pathway couples nutrient, energy and hormonal signals with eukaryotic cell growth and division. In yeast, TORC1 coordinates growth with G1–S cell cycle progression, also coined as START, by favouring the expression of G1 cyclins that activate cyclin-dependent protein kinases (CDKs) and by destabilizing the CDK inhibitor Sic1. Following TORC1 downregulation by rapamycin treatment or nutrient limitation, clearance of G1 cyclins and C-terminal phosphorylation of Sic1 by unknown protein kinases are both required for Sic1 to escape ubiquitin-dependent proteolysis prompted by its flagging via the SCFCdc4 (Skp1/Cul1/F-box protein) ubiquitin ligase complex.…

Latvijas bēgļu atgriešanās

1922

Cardiac response to Nage no Kata in judo

2021

The first world judo Kata competition was held in October 2007 in Tokyo, Japan. The Nage no Kata was developed in 1884 and 1885 at the Kodokan. by Jigoro Kano, the founder of judo, who developed Kata to demonstrate the principles of judo and to provide a type of training which emphasized performing techniques under controlled setting. According to Kano, to fully develop judo skills, it is essential to involve both Randori and Kata techniques [1]. Most highgrade Japanese judo teachers emphasize the importance of Kata performance for judokas’ development, in particular Nage no Kata [2]. Results of the study conducted by Canestri et al. [3] suggested that session-RPE and HR monitoring is a sim…

L'Europa dopo Lisbona: cosa cambia

2010

Sommario: 1. Un primo, sintetico, quadro generale; 2. Due Corti a confronto; 2.1 Storia, competenze ed ambito d’azione della Corte di giustizia; 2.1.1 Quali novità nel sistema giudiziario europeo dopo l’entrata in vigore del Trattato di Lisbona? Una panoramica; 2.2 Il funzionamento della Corte europea dei diritti dell’uomo;3. I rapporti tra le Corti sul piano interpretativo; 4. Interazione tra Carta dei diritti fondamentali e Convenzione all’indomani dell’adesione dell’Unione alla CEDU; 5. Un nuovo scenario su cui riflettere: l’esecuzione delle sentenze in caso di condanna dell’Unione; 6. Gli Stati e il problema della doppia appartenenza: lo “spartiacque” Lisbona; 7. Nelle maglie della “ret…

Giovani virtuosi e dove trovarli: Percorsi formativi e rappresentazioni dell’età giovanile nella tradizione pedagogica e letteraria cinese

2021

Infanzia ed educazione sono tematiche in cui è presente una forte dicotomia: hanno per natura una componente universale, in quanto presenti nell’organizzazione sociale fin dai tempi più antichi, ma allo stesso tempo sono fortemente caratterizzate e influenzate dall’ambiente culturale in cui si evolvono In Cina, testi classici e pratiche sociali sono solo due degli elementi che hanno contribuito a modellare il carattere originale del bambino, la cui formazione, nel corso della storia del pensiero cinese, fu influenzata dalle grandi dottrine – buddhismo, daoismo e confucianesimo – e successivamente dall’incontro con l’Occidente. Attraverso un variegato corpus di fonti primarie – trattati filo…

Recensione al volume Thrift N., Non-Representational Theory, London and New York, Routledge, 2008, 326 pp., in Rivista Geografica Italiana, CXVIII, f…

2011

Si può affermare che un’osservazione di tipo non-rappresentazionale (o forse meglio non rappresentativa) consideri un fenomeno geografico come continuamente in evoluzione a causa di azioni, opportunità, interazioni, flussi (finanziari, di informazioni, di persone) e nuovi processi transterritoriali che devono essere gestiti diversamente rispetto al passato. La nuova prospettiva considera dunque molto significativi gli improvvisi nuovi equilibri che derivano in sostanza dalla globalizzazione e in particolare dalla tecnologia. Si ritiene pertanto complessa una sistematizzazione delle conoscenze, una definizione del fenomeno e l’affermazione di una sola verità condivisa. Vengono riformulati i …