Search results for " RAS"
showing 10 items of 218 documents
La lotta alla mafia vista dai quotidiani. Una rassegna stampa “ragionata”
2009
Studiare il bullismo nelle scuole. Metodi e strumenti per rilevare gli atteggiamenti degli insegnanti
2021
Lo studio degli atteggiamenti pone due problemi di fondo dai quali non si può prescindere. Il primo è di natura epistemologica e riguarda la definizione stessa dell'oggetto di studio e la sua osservabilità. L'atteggiamento, proprio per la sua natura di "costrutto ipotetico", di variabile "interveniente" o "di mediazione", di variabile "latente", non è direttamente osservabile ed è, in potenza, inferibile esclusivamente da un'espressione o da un comportamento manifesto, ossia si osserva a un livello più specifico per cogliere empiricamente un oggetto collocato a un livello di maggiore generalità. Il secondo è di natura metodologica ed è relativo ai nodi critici che caratterizzano la rilevazi…
Un sistema di piazze per Paceco (TP) e un progetto per il “parco tematico Floriopoli” a Creda (PA)
2015
Un breve testo che spiega due progetti di Santo Giunta (capogruppo), Un sistema di piazze per Paceco (TP) e un progetto per il “parco tematico Floriopoli” a Creda (PA), per la mostra “architetture 2010/2012” organizzata e curata da Mario Chiavetta per OAPPC di Palermo.
Targeted therapy for hepatocellular carcinoma: novel agents on the horizon.
2012
Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to be the most lethal of the cancer systems, accounting for approximately one third of all malignancies. Although the clinical diagnosis and management of early-stage HCC has improved significantly, HCC prognosis is still extremely poor. Furthermore, advanced HCC is a highly aggressive tumor with a poor or no response to common therapies. Therefore, new effective and well-tolerated therapy strategies are urgently needed. Targeted therapies have entered the field of anti-neopl…
Estimating person parameters via item response model and simple sum score in small samples with few polytomous items: A simulation study
2018
Background The Item Response Theory (IRT) is becoming increasingly popular for item analysis. Theoretical considerations and simulation studies suggest that parameter estimates will become precise only by utilizing many items in large samples. Method A simulation study focusing on a single scale was performed on data with (a) n = 40, 60, 80, 120, 200, 300, 500, and 900 cases utilizing (b) 4, 8, 16, or 32 items. The items were (c) symmetrically distributed vs. skew (skewness 0, 1, and 2). Item loadings were (d) homogeneous vs. heterogeneous. Item loadings were (e) low vs. high. Half of the items had (f) a correlated error or not. The number of answering categories (g) was four vs. five. A to…
Ricci-flow based conformal mapping of the proximal femur to identify exercise loading effects.
2018
AbstractThe causal relationship between habitual loading and adaptive response in bone morphology is commonly explored by analysing the spatial distribution of mechanically relevant features. In this study, 3D distribution of features in the proximal femur of 91 female athletes (5 exercise loading groups representing habitual loading) is contrasted with 20 controls. A femur specific Ricci-flow based conformal mapping procedure was developed for establishing correspondence among the periosteal surfaces. The procedure leverages the invariance of the conformal mapping method to isometric shape differences to align surfaces in the 2D parametric domain, to produce dense correspondences across an…
Antisense gene therapy using anti-k-ras and antitelomerase oligonucleotides in colorectal cancer
2005
Aim: to test the efficacy of anti-k-ras and antitelomerase oligonucleotides for disabling colorectal cancer cell growth. Material and methods: an established human colorectal cancer cell line (SW 480, ATTC ® ) was used. Oligodeoxiribonucleotides (ODNs) have a phosphorotioate modification to ensure intracellular intake. We used an antitelomerase ODN (Telp5) and two anti-k-ras ODNs (AS-KRAS and ISIS). AS-KRAS is designed to join the k-ras oncogene’s exon 1. ISIS links to the terminal transcription unit 5’ of k-ras. Telp5 joins the template region of the hTR telomerase subunit. ODNs have been tested in different concentrations (1, 5, 10, 20 micromolar). Cell viability has been tested at 48 and…
Sisó, Sisón (VER0000206)
Little Bustard (Anglès), Outarde canepetière (Francès), Zwergtrappe (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 24-1 Ossa de Montiel HembraMacho Adultos
Regulation ofMUC1Expression in Human Mammary Cell Lines by the c-ErbB2 and Ras Signaling Pathways
2001
The MUC1 protein is a highly O-glycosylated transmembrane molecule that is expressed at the luminal surface of most glandular epithelial cells and is upregulated in carcinomas. Here, we report the effect of the activation of the c-ErbB2 --Ras pathway on the expression of the MUC1 gene in the nontumorigenic mammary cell lines MTSV1-7 and HB2 and in the malignant cell lines T47D and ZR75. Endogenous levels of MUC1 mRNA and protein in HB2 clones permanently overexpressing c-ErbB2 or V12-H-Ras were markedly reduced compared with levels in the parental cell lines. Furthermore, in transient transfection assays, the transcription of a CAT reporter construct driven by the MUC1 promoter was inhibite…
La estructura retórica y la inspiración senequiana de la Canción al Oro de Juan de Jáuregui
2020
Este artículo estudia el diseño retórico de la ?Canción al Oro? del poeta sevillano Juan de Jáuregui y rastrea los textos de Séneca que pudieron inspirarle, así como otros pertenecientes a Horacio, Virgilio y Ovidio, conforme a la práctica renacentista de la imitatio. Entre las formas líricas y retóricas que se reconocen destacan el himno, la priamel y el epichirema, y en lo referente a las fuentes primarias se concluye que las Epistulae morales y el tratado De beneficiis de Séneca tuvieron un papel relevante.