Search results for " RAS"
showing 10 items of 218 documents
Partial restoration of pre-transformation levels of lysyl oxidase and transin mRNAs in phenotypic ras revertants.
1995
Neoplastic transformation mediated by ras oncogenes is associated with deregulated expression of genes encoding, for example, various proteases, lysyl oxidase, and smooth-muscle α-actin. To define the role of these genes in the initiation or maintenance of the ras-transformed state, we compared their steady-state mRNA levels in two different sets of preneoplastic fibroblast lines, ras-transformed clones, and phenotypic revertants derived from them. Compared with the preneoplastic fibroblasts, the ras-transformed derivatives exhibited elevated levels of cathepsin L (major excreted protein), transin (stromelysin I, matrix metalloproteinase–3), and collagenase I (matrix metalloproteinase–1) mR…
Abstract PS11-11: Targeted safety events from a phase I/Ib study evaluating GDC-0077 alone and in combination with endocrine therapy (ET) ± palbocicl…
2021
Abstract Background Activating mutations in PIK3CA, encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3K) occur in ~40% of HR+/HER2- BCs. GDC-0077, a PI3Kα-selective inhibitor and mutant PI3Kα degrader, is being developed as an anticancer agent. A phase I/Ib study of GDC-0077 alone and combined with other therapies is ongoing in pts with locally advanced or metastatic PIK3CAmut, HR+/HER2- mBC (NCT03006172). Targeted safety events are presented here. Methods Safety was assessed via NCI-CTCAE v4 for GDC-0077 administered alone (Arm A), with letrozole and palbo (Arm B), with letrozole (Arm C), with fulvestrant (Arm D), or with fulvestrant and palbo (Arm E, plus metformin in Arm F …
Differential regulation of the clusterin gene by Ha-ras and c-myc oncogenes and during apoptosis
1998
Clusterin (ApoJ) is an extracellular glycoprotein expressed during processes of tissue differentiation and regression that involve programmed cell death (apoptosis). Increased clusterin expression has also been found in tumors, however, the mechanism underlying this induction is not known. Apoptotic processes in tumors could be responsible for clusterin gene activation. Alternatively, oncogenic mutations could modulate signal transduction, thereby inducing the gene. We examined the response of the rat clusterin gene to two oncogenes, Ha-ras and c-myc, in transfected Rat1 fibroblasts. While c-myc overexpression did not modify clusterin gene activity, the Ha-ras oncogene produced a seven to t…
Origin of the integrin-mediated signal transduction. Functional studies with cell cultures from the sponge Suberites domuncula
1999
Sponges (phylum Porifera) represent the phylogenetically oldest metazoan animals. Recently, from the marine sponge Geodia cydonium a first cDNA encoding a putative integrin receptor molecule was isolated. In the present study basic functional experiments have been conducted to test the hypothesis that in sponges integrin polypeptides also function as adhesion molecules and as outside-in signaling molecules. The sponge Suberites domuncula has been used for the experiments because from this sponge only has a cell culture been established. Here we report that aggregation factor (AF)-mediated cell-cell adhesion is blocked by the RGDS peptide which is known to interact with beta integrin. Both R…
Latvijas nekustamā īpašuma tirgus datu kopas izveide un analīze
2020
Bakalaura darba „Latvijas nekustamā īpašuma tirgus datu kopas izveide un analīze” mērķis ir aplūkot veidus kā no nestrukturētiem datiem, kas ir pieejami tīmeklī, izveidot datu kopu, ko būtu iespējams izmantot dažādiem lietojumiem. Darbā apskatīta esošā situācija datu pieejamībā par Latvijas nekustamā īpašuma tirgu. Aplūkotas datu kopas un atvērtie dati Latvijā, datu un datu kopu kvalitātes novērtēšana, kā arī veidi kā iegūt strukturētus datus no tīmekļa vietnēm un datu ieguves procesu automatizācija. Darba praktiskajā daļā izveidots rasmotājs, kas automatizēti spēj iegūt strukturētus datus no sludinājuma portāla un no tiem izveidot datu kopu, kā arī veikta izveidotās datu kopas analīze. Dar…
Rasmotāja izstrāde Latvijas Atvērto datu portāla analīzei
2021
Rasmošana ir veids kā ātri iegūt nepieciešamo informāciju no tīmekļu vietnēm. Darba mērķis ir izstrādāt rasmotāju Latvijas Atvērto datu portālam. Darbā tiek apskatīts rasmošanas princips un tās vēsture. Tiek izpētīta rasmotāju darbība un veikts trīs brīvi pieejamu rasmotāju pārskats un analīze. Analīzes rezultāti kalpo par izstrādājamā rasmotāja specifikāciju, kā arī rasmošanas rezultātā iegūtie faili tiek salīdzināti ar izstrādāto rasmotāju. Pirms rasmotāja izstrādes darbā tiek arī apskatīts “atvērto datu” jēdziens un vēsture. Tā kā izstrādātais rasmotājs tiks testēts Latvijas Atvērto datu portālā, tas tiek īsi analizēts. Darba mērķis ir sasniegts un rasmotājs ir izstrādāts, iegūstot CSV f…
Efficacy of GLP-1 RA Approved for Weight Management in Patients With or Without Diabetes: A Narrative Review
2022
The approval of once daily liraglutide, 3.0 mg, and once weekly semaglutide, 2.4 mg, for chronic weight management provides a novel effective strategy against obesity. The reliable models that might predict weight reducing potential at the individual level have not been identified yet. However, the coexistence of diabetes has been consistently related with less effective response than in people without this comorbidity. We aimed to review the efficacy of GLP-1 RAs approved for weight management in individuals with and without diabetes and discuss some potential mechanisms for consistently observed differences in efficacy between these two populations. The mean weight loss difference between…
Rasch measurement in educational contexts Special issue 1: Rasch modeling in educational testing
2011
This is the first of two special journal issues on Rasch measurement in educational contexts. Most of the articles compiled in these two issues originate from a symposium of the same title held in ...
Advantages of the Rasch measurement model in analysing educational tests:an applicator's reflection
2011
Educational achievement is a very important issue for parents, teachers, and the government. An accurate measurement plays a very important role in evaluating achievement fairly, and, therefore, analysis methods have been developed considerably in recent years. Education based on long-time learning processes forms a fruitful base for item tests, as it opens up possibilities to design a nearly unlimited number of items. There are several methods available to analyse such tests, but which method is the most useful and in which situation? The Rasch measurement from the Institute for Object Measurement (IOM) has pointed out to be the most useful in evaluating individual items and their function…