Search results for " RAS"

The peach volatilome modularity is reflected at the genetic and environmental response levels in a QTL mapping population

2014

Background: The improvement of fruit aroma is currently one of the most sought-after objectives in peach breeding programs. To better characterize and assess the genetic potential for increasing aroma quality by breeding, a quantity trait locus (QTL) analysis approach was carried out in an F-1 population segregating largely for fruit traits. Results: Linkage maps were constructed using the IPSC peach 9 K Infinium (R) II array, rendering dense genetic maps, except in the case of certain chromosomes, probably due to identity-by-descent of those chromosomes in the parental genotypes. The variability in compounds associated with aroma was analyzed by a metabolomic approach based on GC-MS to pro…

Biological characterization of laryngeal squamous-cell carcinoma

1996

The traditional prognostic factors, including stage of disease and tumour grade, have shown a limited prognostic significance and an inability to predict clinical response to specific treatment in patients with laryngeal squamous-cell carcinoma. More recent data suggest that cell kinetics indices, DNA-ploidy, lysosomal cysteine proteinase expression and genetic changes of both tumour suppressor genes and proto-oncogenes may be considered as reliable and reproducible indicators of biological aggressiveness in these patients. Moreover, the frequency of different genetic alterations suggests that several pathways are involved in the genesis of these neoplasias and, in particular, it is very pr…

Laser Pressure Catapulting (LPC): Optimization LPC-System and Genotyping of Colorectal Carcinomas

2005

Genotype analysis is becoming more and more useful in clinical practice, since specific mutations in tumors often correlate with prognosis and/or therapeutic response. Unfortunately, current molecular analytical techniques often require time-consuming and costly steps of analysis, thus making their routine clinical use difficult. Moreover, one of the most difficult problems arising during tumor research is that of their cell heterogeneity, which depends on their clear molecular heterogeneity. SSCP analysis discriminates by means of aberrant electrophoresis migration bands, mutated alleles which may represent as little as 15-20% of their total number. Nevertheless, in order to identify by se…

Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activatio…

1999

To test the Kirsten-Ras (Ki-Ras) alternative prenylation hypothesis in malignant transformation, we used a novel farnesyltransferase inhibitor competitive to farnesyl-pyrophosphate, RPR130401, and a CaaX peptidomimetic geranylgeranyltransferase-1 inhibitor GGTI-298. In Ki-Ras-overexpressing transformed adrenocortical cells, RPR130401 at 1-10 microM inhibited very efficiently the [(3)H]farnesyl but not [(3)H]geranylgeranyl transfer to Ras. However, proliferation of these cells was only slightly sensitive to RPR130401 (IC(50)=30 microM). GGTI-298 inhibited the growth of these cells with an IC(50) of 11 microM but cell lysis was observed at 15 microM. The combination of 10 microM RPR130401 and…

Prediction of the difficulty level in a standardized reading comprehension test : contributions from cognitive psychology and psychometrics

2013

Esta investigación busca identificar posibles variables predictoras del nivel de dificultad de los ítems de comprensión de lectura utilizados en una prueba psicométrica estandarizada para la admisión a una institución universitaria. Se propusieron varios posibles predictores del nivel de dificultad, a saber: densidad proposicional, negaciones, estructura sintáctica, dificultad del vocabulario, presencia elementos de realce (palabras resaltadas tipográficamente), abstracción del ítem y grado de similitud entre opción correcta y texto relevante para resolver el ítem. Mediante el Modelo Logístico Lineal de Rasgo Latente se encontró que la cantidad de proposiciones, la estructura sintáctica y, …

Grua amb caperutxo, Grua coronada collnegra, Grulla coronada cuellinegra, grulla real negra (VER0000234)

Black Crowned-Crane (Anglès), Grue couronnée (Francès), Kronenkranich (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 11-2 Juvenil

Grua, Grulla común (VER0000204)

1932

Common Crane (Anglès), Grue cendrée (Francès), Kranich (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 11-2

Grua, Grulla común (VER0000093)

Altres noms vulgars: Common Crane (Anglès), Grue cendrée (Francès), Kranich (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 9-2 Valencia Hembra Juvenil

Polla d'aigua, Focha común (VER0000097)

1890

Altres noms vulgars: Common Coot (Anglès), Foulque macroule (Francès), Bläßhuhn (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 12-2 La Albufera. Coto de la Calderería 00/00/1890 Juvenil Leucística

Polla d'aigua, Polla de agua (VER0000096)

Altres noms vulgars: Common Moorhen (Anglès), Common Moorhen (Francès), Common Moorhen (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 10-1 La Albufera Juvenil