Search results for " REPOSI"

The In Silico Fischer Lock-and-Key Model: The Combined Use of Molecular Descriptors and Docking Poses for the Repurposing of Old Drugs

2019

Not always lead compound and/or derivatives are suitable for the specific biological target for which they are designed but, in some cases, discarded compounds proved to be good binders for other biological targets; therefore, drug repurposing constitute a valid alternative to avoid waste of human and financial resources. Our virtual lock-and-key methods, VLKA and Conf-VLKA, furnish a strong support to predict the efficacy of a designed drug a priori its biological evaluation, or the correct biological target for a set of the selected compounds, allowing thus the repurposing of known and unknown, active and inactive compounds.

Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy

2020

Abstract The progressively rising drug resistance has driven the development of chemosensitizers, which aim to enhance the current chemotherapeutic efficacy through either quantitatively increasing intracellular drug concentration by inhibiting drug efflux, vesicle sequestration, and metabolic inactivation or qualitatively exerting concomitant effects on cellular regulation to promote apoptosis. Given the high failure rates and costs during standard drug development, drug repurposing represents an effective and economic approach for chemosensitizer identification. By applying drug repurposing, a wide range of existing clinic drugs including anticardiovascular agents, immunosuppressants, ant…

Direct lookup and hash-based metadata placement for local file systems

2013

New challenges to file systems' metadata performance are imposed by the continuously growing number of files existing in file systems. The total amount of metadata can become too big to be cached, potentially leading to multiple storage device accesses for a single metadata lookup operation. This paper takes a look at the limitations of traditional file system designs and discusses an alternative metadata handling approach, using hash-based concepts already established for metadata and data placement in distributed storage systems. Furthermore, a POSIX compliant prototype implementation based on these concepts is introduced and benchmarked. A variety of file system metadata and data operati…

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology

2020

Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions. Here, we compared interpatient molecular heterogeneities of tumors and repertoires of drugs or their molecular targets currently in use in clinical oncology. We estimated molecular heterogeneity using genomic (whole exome sequencing) and transcriptomic (RNA sequencing) data for 4890 tumors taken from The Cancer Genome Atlas database. For thirteen major cancer types, we compared heterogeneities at the levels of mutations and gene expression with the repertoires of targeted therapeutics and their molecular targets accepted by the current guideli…

Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-based Pharmacophore Modeling/Docking Approach

2020

To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each…

New geo-portal for MODIS/SEVIRI image products with geolocation-based retrieval functionality

2015

A large number of remote sensing data sets have been collected in recent years by Earth observation instruments such as the moderate resolution imaging spectroradiometer (MODIS) aboard the Terra/Aqua satellite and the spinning enhanced visible and infrared imager (SEVIRI) aboard the geostationary platform Meteosat Second Generation. The advanced remote sensing products resulting from the analysis of these data are useful in a wide variety of appli- cations but require significant resources in terms of storage, retrieval, and analysis. Despite the wide availability of these MODIS/SEVIRI products, the data coming from these instruments are spread among different locations and retrieved from d…

Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis

2015

Type de document : revue de littérature; International audience; Background The health benefits of 150 min a week of moderate-to-vigorous-intensity physical activity (MVPA) in older adults, as currently recommended, are well established, but the suggested dose in older adults is often not reached.Objectives We aimed to determine whether a lower dose of MVPA was effective in reducing mortality, in participants older than 60 years.Methods The PubMed and Embase databases were searched from inception to February 2015. Only prospective cohorts were included. Risk ratios of death were established into four doses based on weekly Metabolic Equivalent of Task (MET)-minutes, defined as inactive (refe…

The availability of raw data in substance abuse scientific journals

2018

[Objective]: The availability of research data sets is an important milestone since it can enhance the dynamics of research. This study aims to analyse the PubMed Central repository to determine the availability and type of raw data sets in Substance Abuse journals indexed in the Journal Citation Reports.

La qualità inclusiva della scuola: dalle pratiche didattiche al profilo del docente inclusivo

2018

L’attenzione della ricerca pedagogica e didattica si rivolge con sempre maggiore consapevolezza ai fattori chiave dei processi di inclusione: la formazione degli insegnanti, lo sviluppo ed il monitoraggio dei contesti educativi nonché la produzione e l’incremento di pratiche didattiche inclusive. Attraverso la ricerca si sono voluti mettere a fuoco tali fattori chiave con la redazione di appositi strumenti che ne permettessero il controllo e la valutazione. Questo lavoro documenta una ricerca della durata di tre anni che ha visto coinvolti docenti in servizio, docenti in formazione frequentanti il terzo anno del corso di Laurea in Scienze della Formazione Primaria e alunni della scuola pri…

QUALITÀ DELL’INCLUSIONE & INCLUSIONE DI QUALITÀ La formazione degli insegnanti e le strategie per promuovere la scuola inclusiva

Lo scenario internazionale si sta muovendo rapidamente verso la promozione di una scuola inclusiva. In Italia, questa realtà è affrontata da molti anni, ma le trasformazioni e il confronto internazionale hanno sollevato nuove domande e riflessioni critiche. In particolare l’attenzione oggi è posta su quello che, come affermato nel corso della Conferenza internazionale dell'UNESCO (2013), è considerato il fattore chiave dei processi di integrazione e di inclusione: la formazione degli insegnanti. L’attenzione della ricerca pedagogica viene posta sui fattori chiave dei processi di inclusione: la formazione degli insegnanti, lo sviluppo ed il monitoraggio dei contesti educativi nonché la …