Search results for " RESISTANCE"
showing 10 items of 2791 documents
Effects of ectopic expression of NGAL on doxorubicin sensitivity.
2012
Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are important in the transport of iron. NGAL also has important biological functions involved in immunity and inflammation as well as responses to kidney damage. NGAL expression has also been associated with certain neoplasia and is important in the metastasis of breast cancer. Many advanced cancer patients have elevated levels of NGAL in their urine and it has been proposed that NGAL may be a prognostic indicator for certain cancers (e.g. breast, brain, and others). NGAL exp…
Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL.
2022
Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing future cardiovascular events. Low-density lipoproteins (LDL) have been successfully targeted, and their reduction is one of the key preventing measures in patients with atherosclerotic disease. LDL particles are pivotal for the formation and progression of atherosclerotic plaques; yet, they are quite heterogeneous, and smaller, denser LDL species are the most atherogenic. These particles have greater arterial entry and retention, higher susceptibility to oxidation, as well a…
Sistemi per la valutazione del compattamento dei terreni agrari
2005
The traffic of agricultural machines can cause soil compaction, reducing, above all, its porosity. The measurement of soil cone penetrometer resistance is the easiest and quickest method for monitoring and assessing soil compaction. The aim of this research is to test two mechanised systems for the geo-referenced measurement and, therefore, producing maps of soil cone penetrometer resistance. The first system was developed mounting an electronic penetrometer and a DGPS mobile receiver on a tracked minitransporter. The second system was built mounting, on a frame fixed to the front part of a tractor: four load cells; a system for signal conditioning and data acquisition; four rods and penetr…
Rill flow velocity and resistance law: A review
2022
Rills caused by runoff concentration on erodible hillslopes generally have very irregular longitudinal profiles and cross-section shapes. Rill erosion directly depends on the hydraulics of flow within the rills which may differ greatly from that in larger and regular channels like streams or rivers. At first, in this paper, a review of the two different approaches to estimate rill flow velocity, based on flow regime and flow resistance laws, is presented. Recent advances in measurements of rill geometry by the three-dimensional photo-reconstruction (3D-PR) technique, which allows one to obtain a Digital Terrain Model (DTM) by low-altitude aerial and terrestrial photogrammetry, are also disc…
Durabilità, in ambiente fortemente basico, delle fibre di PET provenienti dalla raccolta differenziata
2012
La sperimentazione esposta nella presente pubblicazione tratta dell’impiego di fibre di PET, ricavate dal semplice taglio di contenitori per bevande secondo un procedimento brevettato, nel rinforzo di calcestruzzi destinati anche a impieghi strutturali. Descrive le caratteristiche geometriche delle fibre e ne indaga la durabilità in condizioni severe che potrebbero presentarsi in un’applicazione pratica quale una pavimentazione esterna. A tal fine campioni costituiti da gruppi di fibre sono stati immersi per tredici giorni a 65°C in soluzioni a differente concentrazione di NaOH (0,103 M e 1,75 M). In particolare la soluzione a concentrazione 0,103 M di NaOH (pH=13) simula la basicità della …
DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX
2022
The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …
Split exercise training: comparison between endurance-resistance protocol, endurance-resistance-endurance protocol e resistance-endurance protocol.
2009
Numerosi studi hanno dimostrato, per la perdita di peso ed il miglioramento della composizione corporea, l’efficacia della presenza dell’esercizio aerobico ed anaerobico all’interno della stessa seduta di allenamento. Il dibattito resta però aperto riguardo alla distribuzione di queste due metodiche all’interno della medesima sessione, cioè se porre la parte “aerobica” all’inizio dell’allenamento, alla fine o, ancora, se intervallare ad essa il “lavoro anaerobico”. Alla luce di questo abbiamo condotto lo studio preliminare che verrà qui di seguito riportato. Abbiamo esaminato un campione di 25 donne e 11 uomini, per la durata di 6 settimane; i 2 gruppi sono stati suddivisi, a loro volta, in…
Experimental analysis, numerical and analytical modeling of shear strength mechanisms in Hybrid Steel Trussed Concrete Beams
2014
Does Stretching Training Influence Muscular Strength? A Systematic Review With Meta-Analysis and Meta-Regression
2022
Thomas, E, Ficarra, S, Nunes, JP, Paoli, A, Bellafiore, M, Palma, A, and Bianco, A. Does stretching training influence muscular strength? A systematic review with meta-analysis and meta-regression. J Strength Cond Res XX(X): 000-000, 2022-This aim of this study was to review articles that performed stretching training and evaluated the effects on muscular strength. Literature search was performed using 3 databases. Studies were included if they compared the effects on strength following stretching training vs. a nontraining control group or stretching training combined with resistance training (RT) vs. an RT-only group, after at least 4 weeks of intervention. The meta-analyses were performe…
The Effects of Combined Same Session Aerobic and Resistance Training on Physical Performance in Coronary Artery Disease Patients : Protocol Comparison
2021
Aerobic training is included to cardiac rehabilitation programs together with resistance training. The effects of combined aerobic and resistance training performed in a same session with different protocols on peak aerobic capacity (VO2peak) and maximal dynamic strength (1RM: one repetition maximum) are not well known. We compared the effectiveness of two different combined aerobic and resistance training programs for 12 weeks performed three times in a week in stable Coronary Artery Disease (CAD) patients (n=30) who had previously performed aerobic training only. The patients were randomized to High Volume- Low Intensity Group (HLG) or Low Volume-High Intensity Group (LHG). Both groups pe…