Search results for " Randomized Controlled Trial"

showing 10 items of 54 documents

The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes

2015

Background. Critically ill patients appear to be at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism during their stay in the intensive care unit (ICU). However, little is known about the clinical course of venous thromboembolism in the ICU setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of DVT on hospital and ICU stay, duration of mechanical ventilation and mortality in critically ill patients. We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the ICU setting. Materials and methods. MEDLINE and EMBASE databases were searched up…

RiskCritical IllnessIntensive Care UnitCritically ill patients; Deep vein thrombosis; Meta-analysis; Outcomes; Cohort Studies; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Pulmonary Embolism; Randomized Controlled Trials as Topic; Research Design; Respiration Artificial; Risk; Thrombophilia; Treatment Outcome; Venous Thrombosis; Critical Illness; Hematology; Immunology and AllergyReviewDeep Vein Thrombosis Critically Ill Patients outcomes metanalysisCohort StudiesDeep vein thrombosiImmunology and AllergyHumansThrombophiliaMeta-analysiVenous ThrombosiHospital MortalityOutcomeRandomized Controlled Trials as TopicVenous ThrombosisHematologyLength of StayRespiration ArtificialIntensive Care UnitsTreatment OutcomeResearch DesignCritical IllneCritically ill patientCohort StudiePulmonary EmbolismHuman
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[Choosing a quality-of-life questionnaire].

2006

International audience; Define the objective of the questionnaire: Discrimination: do you want a questionnaire to enable you to describe the quality of life of patients or to compare the quality of life between groups of patients, for example, to determine who has improved and who has gotten worse? Assessment: do you want a questionnaire to help you measure changes over time (improvement or aggravation) in your patients? Determine the properties of instruments necessary for this objective: If the objective is discrimination, analyze: construct validity, reliability. If the objective is assessment, analyze construct validity, sensitivity to changes. Choose the general category of questionnai…

Time FactorsHealth StatusMESH : Randomized Controlled Trials as TopicMESH : Multicenter Studies as Topic[ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesSurveys and QuestionnairesActivities of Daily LivingHumansMulticenter Studies as TopicMESH : Health StatusMESH: Health StatusRandomized Controlled Trials as TopicMESH: HumansMESH: QuestionnairesMESH: Activities of Daily LivingMESH: Time FactorsMESH : HumansMESH: Quality of Life[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesMESH : QuestionnairesMESH : Follow-Up StudiesMESH: Follow-Up StudiesMESH : Quality of LifeMESH: Randomized Controlled Trials as TopicQuality of LifeMESH: Multicenter Studies as TopicMESH : Activities of Daily Living[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesFollow-Up StudiesMESH : Time Factors
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Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICa…

2019

Background Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Internet- and mobile-based interventions (IMIs) may be an effective means to deliver psychological interventions on a large scale for the prevention of common mental disorders (CMDs) such as depression and anxiety. IMIs have been shown to be effective in treating CMDs, e.g. in reducing symptoms of depression and an…

Transdiagnosticlcsh:T58.5-58.64lcsh:Information technologyDepressionPreventionlcsh:BF1-990610 Medicine & healthInternet-basedAnxietyArticlelcsh:PsychologyQA76 Computer softwareSDG 3 - Good Health and Well-beingRandomized controlled trial/dk/atira/pure/core/keywords/600089002/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingPsychologyddc:158150 PsychologyPrevention Transdiagnostic Depression Anxiety Internet-based Randomized controlled trialRC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS

2021

AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…

cardiovascular disease; meta-analysis; randomized controlled trials; stem cells; umbrella review0301 basic medicineUmbrella review.Agingmedicine.medical_specialtyMyocardial InfarctionStem cellsPlaceboBiochemistrylaw.invention03 medical and health sciencesUmbrella review0302 clinical medicineRandomized controlled triallawIntervention (counseling)medicineHumansMeta-analysicardiovascular diseasesMyocardial infarctionIntensive care medicineMolecular BiologyRandomized Controlled Trials as TopicStem cellbusiness.industrymedicine.diseaseCardiovascular diseaseIntervention studiesMeta-analysisCardiovascular diseases030104 developmental biologySystematic reviewAN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS.- Ageing research reviews ss.101257 2021 [Demurtas J. Fanelli G. N. Romano S. L. Solari M. Yang L. Soysal P. Sánchez G. F. L. Grabovac I. Smith L. Zorzi A. et al. -STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES]NeurologyCardiovascular DiseasesRandomized controlled trialMeta-analysisCardiovascular disease; Meta-analysis; Randomized controlled trials; Stem cells; Umbrella review; Humans; Randomized Controlled Trials as Topic; Stem Cells; Cardiovascular Diseases; Myocardial InfarctionRandomized controlled trialsCardiovascular disease; Stem cells; Umbrella review; Meta-analysis; Randomized controlled trialsStem cellbusiness030217 neurology & neurosurgeryBiotechnology
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Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

2022

Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23rd November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as…

magnesium; inflammation; C reactive protein; tumor necrosis factor; randomized controlled trial; meta-analysisNutrition and DieteticsC reactive proteinNutrition. Foods and food supplytumor necrosis factorMiddle Agedmagnesiummeta-analysisinflammationDietary Supplementsrandomized controlled trialHumansTX341-641BiomarkersRandomized Controlled Trials as TopicFood Science
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Intervention studies to foster resilience – A systematic review and proposal for a resilience framework in future intervention studies

2017

Psychological resilience refers to the phenomenon that many people are able to adapt to the challenges of life and maintain mental health despite exposure to adversity. This has stimulated research on training programs to foster psychological resilience. We evaluated concepts, methods and designs of 43 randomized controlled trials published between 1979 and 2014 which assessed the efficacy of such training programs and propose standards for future intervention research based on recent developments in the field. We found that concepts, methods and designs in current resilience intervention studies are of limited use to properly assess efficacy of interventions to foster resilience. Major pro…

media_common.quotation_subjectApplied psychologyPsychological interventionlaw.inventionAssessment ; Intervention ; Training ; Randomized controlled trial ; Resilience ; Stress03 medical and health sciences0302 clinical medicineRandomized controlled triallawIntervention (counseling)Adaptation PsychologicalHumans030212 general & internal medicineRandomized Controlled Trials as Topicmedia_commonClinical study designStressorResilience PsychologicalMental healthPsychiatry and Mental healthClinical PsychologyMental HealthFoster carePsychological resiliencePsychologyStress Psychological030217 neurology & neurosurgeryClinical psychologyClinical Psychology Review
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High flow nasal therapy in immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis.

2019

Abstract Purpose The role of high-flow nasal therapy (HFNT) as compared to conventional oxygen therapy (COT) in immunocompromised patients admitted to intensive care unit (ICU) with acute respiratory failure (ARF) remains unclear. We conducted a systematic review and meta-analysis in order to address this issue. Methods We searched PubMed, Medline and Embase until November 7th, 2018. Randomized controlled trials (RCTs), non-randomized prospective and retrospective evidence were selected. Observational studies were considered for sensitivity analysis. Primary outcome was mortality rate; intubation rate was a secondary outcome. Results We included four studies in the primary analysis: one RCT…

medicine.medical_specialtyCritical CareAcute respiratory failure High flow nasal cannula High flow nasal therapy Immunocompromised patients Mechanical ventilation Noninvasive ventilation Oxygen therapy Cannula Humans Immunocompromised Host Intubation Intratracheal Noninvasive Ventilation Oxygen Inhalation Therapy Randomized Controlled Trials as Topic Respiratory Distress Syndrome Adult Critical Caremedicine.medical_treatmentAcute respiratory failureCritical Care and Intensive Care Medicinelaw.inventionImmunocompromised Host03 medical and health sciencesMechanical ventilation0302 clinical medicineRandomized controlled triallawInternal medicineOxygen therapyIntubation IntratrachealImmunocompromised patientmedicineCannulaHumansIntubationHigh flow nasal therapyRandomized Controlled Trials as TopicRespiratory Distress Syndromebusiness.industryMortality rateOxygen Inhalation Therapy030208 emergency & critical care medicineRetrospective cohort studyOdds ratioOxygen therapyIntensive care unitHigh flow nasal cannula030228 respiratory systemMeta-analysisbusinessNoninvasive ventilation
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Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis

2004

Background: The benefit of neoadjuvant chemoradiotherapy in oesophageal cancer has been extensively studied but data on survival are still equivocal. Objective: To assess the effectiveness of chemoradiotherapy followed by surgery in the reduction of mortality in patients with resectable oesophageal cancer. Methods: Computerised bibliographic searches of MEDLINE and CANCERLIT (1970–2002) were supplemented with hand searches of reference lists. Study selection: Studies were included if they were randomised controlled trials (RCTs) comparing preoperative chemoradiotherapy plus surgery with surgery alone, and if they included patients with resectable histologically proven oesophageal cancer wit…

medicine.medical_specialtyEsophageal Neoplasmsmedicine.medical_treatmentlaw.inventionPostoperative ComplicationsRandomized controlled triallawChemotherapyHumansMedicineEsophageal NeoplasmAdjuvantRandomized Controlled Trials as TopicIntention-to-treat analysisRadiotherapybusiness.industryMortality rateGastroenterologyCancerOdds ratiomedicine.diseaseChemotherapy Adjuvant; Esophageal Neoplasms; Esophagectomy; Humans; Postoperative Complications; Radiotherapy Adjuvant; Randomized Controlled Trials; Survival Analysis; Treatment OutcomeSurvival AnalysisSurgeryEsophagectomyRadiation therapyOesophagusTreatment OutcomeChemotherapy AdjuvantEsophagectomyRandomized Controlled TrialChemotherapy; Adjuvant; Esophageal Neoplasms; Esophagectomy; Humans; Postoperative Complications; Radiotherapy; Randomized Controlled Trials as Topic; Survival Analysis; Treatment OutcomeRadiotherapy AdjuvantPostoperative ComplicationSurvival AnalysibusinessChemoradiotherapyHumanGut
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Prevention and management of musculoskeletal pain in nursing staff by a multifaceted intervention in the workplace: design of a cluster randomized co…

2018

Musculoskeletal pain (MSP) is the leading cause of years lived with disability. In consequence, to reduce MSP and its associated sickness absence is a major challenge. Previous interventions have been developed to reduce MSP and improve return to work of workers with MSP, but combined approaches and exhaustive evaluation are needed. The objective of the INTEVAL_Spain project is to evaluate the effectiveness of a multifaceted intervention in the workplace to prevent and manage MSP in nursing staff. The study is designed as a two-armed cluster randomized controlled trial with a late intervention control group. The hospital units are the clusters of randomization and participants are nurses an…

medicine.medical_specialtyMultifaceted interventionReturn to workCost-Benefit AnalysisMusculoskeletal painPsychological intervention030209 endocrinology & metabolismContext (language use)Nursing Staff HospitalCluster randomized controlled triallaw.inventionCase management03 medical and health sciencesStudy Protocol0302 clinical medicineRandomized controlled triallawIntervention (counseling)Surveys and QuestionnairesSick leavemedicineHumans030212 general & internal medicineOccupational Healthbusiness.industryPublic healthlcsh:Public aspects of medicinePublic Health Environmental and Occupational Healthlcsh:RA1-1270Participatory ergonomicsHealth promotionResearch DesignSpainFamily medicineEconomic evaluationHealth promotionErgonomicsbusinessFollow-Up StudiesBMC public health
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Dropout from exercise randomized controlled trials among people with depression: A meta-analysis and meta regression

2015

Abstract Objective Exercise has established efficacy in improving depressive symptoms. Dropouts from randomized controlled trials (RCT’s) pose a threat to the validity of this evidence base, with dropout rates varying across studies. We conducted a systematic review and meta-analysis to investigate the prevalence and predictors of dropout rates among adults with depression participating in exercise RCT’s. Method Three authors identified RCT’s from a recent Cochrane review and conducted updated searches of major electronic databases from 01/2013 to 08/2015. We included RCT’s of exercise interventions in people with depression (including major depressive disorder (MDD) and depressive symptoms…

medicine.medical_specialtyPatient DropoutseducationDepression Exercise Physical activity DropoutPsychological interventionlaw.inventionRandomized controlled triallawPrevalencemedicineHumansMeta-regressionExerciseDepression (differential diagnoses)Dropout (neural networks)Randomized Controlled Trials as TopicDepressive Disorder MajorDepressive DisorderDepressionPhysical activityDropoutMajormedicine.diseaseExercise TherapyPsychiatry and Mental healthClinical PsychologyMeta-analysisPhysical therapyMajor depressive disorderDepression; Dropout; Exercise; Physical activity; Depression; Depressive Disorder Major; Humans; Patient Dropouts; Prevalence; Randomized Controlled Trials as Topic; Exercise Therapy; Psychiatry and Mental Health; Clinical PsychologyExercise prescriptionPsychology
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