Search results for " Randomized Controlled Trials as Topic"

showing 10 items of 32 documents

Erythropoietin and subarachnoid hemorrhage.

2010

Pathologymedicine.medical_specialtySubarachnoid hemorrhageErytTime Factorserythropoietin subarachnoid hemorragelaw.inventionAnimals; Brain Ischemia; Clinical Trials; Phase II as Topic; Disease Models; Animal; Eryt; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Recombinant Proteins; Subarachnoid Hemorrhage; Time Factors; hropoietinBrain IschemiaBrain ischemialawmedicineAnimalsHumansClinical TrialsRandomized Controlled Trials as TopicSettore MED/27 - Neurochirurgiabusiness.industryAnimalPhase II as TopicGeneral MedicinehropoietinSubarachnoid Hemorrhagemedicine.diseaseRecombinant ProteinsNeuroprotective AgentsErythropoietinDisease ModelsRecombinant DNAbusinessmedicine.drug
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Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protoc…

2018

Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM.PROTHOR is an international, multicenter, randomized, controlled, assessor-blinded, two-arm trial initiated by investigators of the PROtective VEntilation NETwork. In total, 2378 patients will be randomly assigned to one of two different intraoperative me…

Positive-Pressure RespirationMechanical ventilation; one-lung ventilation; positive end-expiratory pressure; postoperative pulmonary complication; recruitment maneuver; thoracic surgery; Humans; Intraoperative Complications; One-Lung Ventilation; Positive-Pressure Respiration; Research Design; Sample Size; Thoracic Surgical Procedures; Randomized Controlled Trials as TopicResearch DesignSample SizeHumansCorrectionThoracic Surgical ProceduresIntraoperative ComplicationsOne-Lung VentilationRandomized Controlled Trials as TopicTrials
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Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.

2014

Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". They are designed to test a therapeutic hypothesis under optimal setting in the absence of confounding factors. For this reason they have high internal validity. The strict and controlled conditions in which they are conducted, leads to low generalizability because they are performed in conditions very different from real life usual care. Conversely, real life studies inform on the "effectiveness" of a treatment, that is, the measure of the extent to which an intervention does what is intended to do in routine circumstances. At variance to RCTs, real …

Pulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtyAsthma; COPD; Randomized controlled trials; Real life studies; Asthma; Confounding Factors (Epidemiology); Humans; Pulmonary Disease Chronic Obstructive; Randomized Controlled Trials as Topic; Research Design; Pulmonary and Respiratory Medicine; Biochemistry (medical); Pharmacology (medical)Alternative medicineSettore MED/10 - Malattie Dell'Apparato Respiratoriolaw.inventionPulmonary DiseasePulmonary Disease Chronic ObstructiveRandomized controlled triallawIntervention (counseling)medicineCOPDHumansPharmacology (medical)Generalizability theoryMedical physicsInternal validityReal life studiesRandomized Controlled Trials as Topicbusiness.industryBiochemistry (medical)Gold standardConfounding Factors EpidemiologicVariance (accounting)Confounding Factors (Epidemiology)AsthmaReal life studieRandomized controlled trials; Real life studies; Asthma; COPDRandomized controlled trialResearch DesignRandomized controlled trialsPhysical therapybusinessStrengths and weaknesses
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Ten important articles on noninvasive ventilation in critically ill patients and insights for the future: A report of expert opinions

2017

Background Noninvasive ventilation is used worldwide in many settings. Its effectiveness has been proven for common clinical conditions in critical care such as cardiogenic pulmonary edema and chronic obstructive pulmonary disease exacerbations. Since the first pioneering studies of noninvasive ventilation in critical care in the late 1980s, thousands of studies and articles have been published on this topic. Interestingly, some aspects remain controversial (e.g. its use in de-novo hypoxemic respiratory failure, role of sedation, self-induced lung injury). Moreover, the role of NIV has recently been questioned and reconsidered in light of the recent reports of new techniques such as high-fl…

Research Reportmedicine.medical_specialtyExacerbationCritical CareCPAP; Non invasive ventilation; Respiratory failure; Critical Care; Critical Illness; Expert Testimony; Forecasting; Humans; Noninvasive Ventilation; Randomized Controlled Trials as Topic; Research Report; Surveys and Questionnaires; Anesthesiology and Pain MedicineCritical IllnessCPAP; Non invasive ventilation; Respiratory failure; Anesthesiology and Pain MedicinePatient characteristicsLung injuryRespiratory failure[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractlaw.inventionlcsh:RD78.3-87.303 medical and health sciences0302 clinical medicineRandomized controlled triallawCPAPAnesthesiologySurveys and QuestionnairesSettore MED/41 - ANESTESIOLOGIAmedicineHumans030212 general & internal medicineMED/41 - ANESTESIOLOGIAIntensive care medicineExpert TestimonyRandomized Controlled Trials as TopicNoninvasive VentilationCritically illbusiness.industryNon invasive ventilation3. Good healthAnesthesiology and Pain Medicine030228 respiratory systemRespiratory failurelcsh:AnesthesiologyCritical Illne[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tractNoninvasive ventilationCPAP; Non invasive ventilation; Respiratory failurebusinessHumanResearch ArticleForecasting
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The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes

2015

Background. Critically ill patients appear to be at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism during their stay in the intensive care unit (ICU). However, little is known about the clinical course of venous thromboembolism in the ICU setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of DVT on hospital and ICU stay, duration of mechanical ventilation and mortality in critically ill patients. We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the ICU setting. Materials and methods. MEDLINE and EMBASE databases were searched up…

RiskCritical IllnessIntensive Care UnitCritically ill patients; Deep vein thrombosis; Meta-analysis; Outcomes; Cohort Studies; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Pulmonary Embolism; Randomized Controlled Trials as Topic; Research Design; Respiration Artificial; Risk; Thrombophilia; Treatment Outcome; Venous Thrombosis; Critical Illness; Hematology; Immunology and AllergyReviewDeep Vein Thrombosis Critically Ill Patients outcomes metanalysisCohort StudiesDeep vein thrombosiImmunology and AllergyHumansThrombophiliaMeta-analysiVenous ThrombosiHospital MortalityOutcomeRandomized Controlled Trials as TopicVenous ThrombosisHematologyLength of StayRespiration ArtificialIntensive Care UnitsTreatment OutcomeResearch DesignCritical IllneCritically ill patientCohort StudiePulmonary EmbolismHuman
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[Choosing a quality-of-life questionnaire].

2006

International audience; Define the objective of the questionnaire: Discrimination: do you want a questionnaire to enable you to describe the quality of life of patients or to compare the quality of life between groups of patients, for example, to determine who has improved and who has gotten worse? Assessment: do you want a questionnaire to help you measure changes over time (improvement or aggravation) in your patients? Determine the properties of instruments necessary for this objective: If the objective is discrimination, analyze: construct validity, reliability. If the objective is assessment, analyze construct validity, sensitivity to changes. Choose the general category of questionnai…

Time FactorsHealth StatusMESH : Randomized Controlled Trials as TopicMESH : Multicenter Studies as Topic[ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesSurveys and QuestionnairesActivities of Daily LivingHumansMulticenter Studies as TopicMESH : Health StatusMESH: Health StatusRandomized Controlled Trials as TopicMESH: HumansMESH: QuestionnairesMESH: Activities of Daily LivingMESH: Time FactorsMESH : HumansMESH: Quality of Life[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesMESH : QuestionnairesMESH : Follow-Up StudiesMESH: Follow-Up StudiesMESH : Quality of LifeMESH: Randomized Controlled Trials as TopicQuality of LifeMESH: Multicenter Studies as TopicMESH : Activities of Daily Living[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesFollow-Up StudiesMESH : Time Factors
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STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS

2021

AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…

cardiovascular disease; meta-analysis; randomized controlled trials; stem cells; umbrella review0301 basic medicineUmbrella review.Agingmedicine.medical_specialtyMyocardial InfarctionStem cellsPlaceboBiochemistrylaw.invention03 medical and health sciencesUmbrella review0302 clinical medicineRandomized controlled triallawIntervention (counseling)medicineHumansMeta-analysicardiovascular diseasesMyocardial infarctionIntensive care medicineMolecular BiologyRandomized Controlled Trials as TopicStem cellbusiness.industrymedicine.diseaseCardiovascular diseaseIntervention studiesMeta-analysisCardiovascular diseases030104 developmental biologySystematic reviewAN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS.- Ageing research reviews ss.101257 2021 [Demurtas J. Fanelli G. N. Romano S. L. Solari M. Yang L. Soysal P. Sánchez G. F. L. Grabovac I. Smith L. Zorzi A. et al. -STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES]NeurologyCardiovascular DiseasesRandomized controlled trialMeta-analysisCardiovascular disease; Meta-analysis; Randomized controlled trials; Stem cells; Umbrella review; Humans; Randomized Controlled Trials as Topic; Stem Cells; Cardiovascular Diseases; Myocardial InfarctionRandomized controlled trialsCardiovascular disease; Stem cells; Umbrella review; Meta-analysis; Randomized controlled trialsStem cellbusiness030217 neurology & neurosurgeryBiotechnology
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High flow nasal therapy in immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis.

2019

Abstract Purpose The role of high-flow nasal therapy (HFNT) as compared to conventional oxygen therapy (COT) in immunocompromised patients admitted to intensive care unit (ICU) with acute respiratory failure (ARF) remains unclear. We conducted a systematic review and meta-analysis in order to address this issue. Methods We searched PubMed, Medline and Embase until November 7th, 2018. Randomized controlled trials (RCTs), non-randomized prospective and retrospective evidence were selected. Observational studies were considered for sensitivity analysis. Primary outcome was mortality rate; intubation rate was a secondary outcome. Results We included four studies in the primary analysis: one RCT…

medicine.medical_specialtyCritical CareAcute respiratory failure High flow nasal cannula High flow nasal therapy Immunocompromised patients Mechanical ventilation Noninvasive ventilation Oxygen therapy Cannula Humans Immunocompromised Host Intubation Intratracheal Noninvasive Ventilation Oxygen Inhalation Therapy Randomized Controlled Trials as Topic Respiratory Distress Syndrome Adult Critical Caremedicine.medical_treatmentAcute respiratory failureCritical Care and Intensive Care Medicinelaw.inventionImmunocompromised Host03 medical and health sciencesMechanical ventilation0302 clinical medicineRandomized controlled triallawInternal medicineOxygen therapyIntubation IntratrachealImmunocompromised patientmedicineCannulaHumansIntubationHigh flow nasal therapyRandomized Controlled Trials as TopicRespiratory Distress Syndromebusiness.industryMortality rateOxygen Inhalation Therapy030208 emergency & critical care medicineRetrospective cohort studyOdds ratioOxygen therapyIntensive care unitHigh flow nasal cannula030228 respiratory systemMeta-analysisbusinessNoninvasive ventilation
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Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis

2004

Background: The benefit of neoadjuvant chemoradiotherapy in oesophageal cancer has been extensively studied but data on survival are still equivocal. Objective: To assess the effectiveness of chemoradiotherapy followed by surgery in the reduction of mortality in patients with resectable oesophageal cancer. Methods: Computerised bibliographic searches of MEDLINE and CANCERLIT (1970–2002) were supplemented with hand searches of reference lists. Study selection: Studies were included if they were randomised controlled trials (RCTs) comparing preoperative chemoradiotherapy plus surgery with surgery alone, and if they included patients with resectable histologically proven oesophageal cancer wit…

medicine.medical_specialtyEsophageal Neoplasmsmedicine.medical_treatmentlaw.inventionPostoperative ComplicationsRandomized controlled triallawChemotherapyHumansMedicineEsophageal NeoplasmAdjuvantRandomized Controlled Trials as TopicIntention-to-treat analysisRadiotherapybusiness.industryMortality rateGastroenterologyCancerOdds ratiomedicine.diseaseChemotherapy Adjuvant; Esophageal Neoplasms; Esophagectomy; Humans; Postoperative Complications; Radiotherapy Adjuvant; Randomized Controlled Trials; Survival Analysis; Treatment OutcomeSurvival AnalysisSurgeryEsophagectomyRadiation therapyOesophagusTreatment OutcomeChemotherapy AdjuvantEsophagectomyRandomized Controlled TrialChemotherapy; Adjuvant; Esophageal Neoplasms; Esophagectomy; Humans; Postoperative Complications; Radiotherapy; Randomized Controlled Trials as Topic; Survival Analysis; Treatment OutcomeRadiotherapy AdjuvantPostoperative ComplicationSurvival AnalysibusinessChemoradiotherapyHumanGut
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Dropout from exercise randomized controlled trials among people with depression: A meta-analysis and meta regression

2015

Abstract Objective Exercise has established efficacy in improving depressive symptoms. Dropouts from randomized controlled trials (RCT’s) pose a threat to the validity of this evidence base, with dropout rates varying across studies. We conducted a systematic review and meta-analysis to investigate the prevalence and predictors of dropout rates among adults with depression participating in exercise RCT’s. Method Three authors identified RCT’s from a recent Cochrane review and conducted updated searches of major electronic databases from 01/2013 to 08/2015. We included RCT’s of exercise interventions in people with depression (including major depressive disorder (MDD) and depressive symptoms…

medicine.medical_specialtyPatient DropoutseducationDepression Exercise Physical activity DropoutPsychological interventionlaw.inventionRandomized controlled triallawPrevalencemedicineHumansMeta-regressionExerciseDepression (differential diagnoses)Dropout (neural networks)Randomized Controlled Trials as TopicDepressive Disorder MajorDepressive DisorderDepressionPhysical activityDropoutMajormedicine.diseaseExercise TherapyPsychiatry and Mental healthClinical PsychologyMeta-analysisPhysical therapyMajor depressive disorderDepression; Dropout; Exercise; Physical activity; Depression; Depressive Disorder Major; Humans; Patient Dropouts; Prevalence; Randomized Controlled Trials as Topic; Exercise Therapy; Psychiatry and Mental Health; Clinical PsychologyExercise prescriptionPsychology
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