Search results for " Regulation"

Data Reporting: Market Structures and Regulatory Framework

2020

The European legislature has identified weaknesses in the functioning and transparency of financial markets as major shortcomings of the regulatory framework under MiFID I. The new MiFID II/MiFIR regime essentially addresses these identified deficits by means of three regulatory measures: First, it considerably extends the scope and increases the stringency of the obligations with regard to pre- and post-trade transparency with a view to improving the quality of pre- and post-trade transparency data. Second, it instigates a shift towards increased trading on regulated trading venues or on other regulated platforms (more extensive market regulation and trading obligations) and, third, it ext…

Market risk reporting in banking overcoming the limits of IAS/IFRS and Basel regulation

2017

Market risk in banking activity is becoming a more severe issue day by day for several reasons. Analysing it from a regulatory point of view is fundamental for assessing whether or not banks are in the conditions of disclosing a satisfactory degree of information about their market risk exposure. The two regulatory constraints to consider are International Accounting Standards (IAS/IFRS) and the Basel regulation. Both of them seem to put too many constraints on banks. They turn out to be over-over-regulated. Even if regulators put many efforts in trying to provide a useful regulation for banks' risk reporting and capital adequacy, we are still far from a good regulation. The regulatory proc…

Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of human endothelial cells

2004

Abstract We have previously shown that a biomaterial consisting of a non-woven fibroin net produced from silk (Bombyx mori) cocoons is an excellent scaffolding material for a wide variety of human cells of different tissue types. Endothelialization must take place for a biomaterial to be successful after implantation. Therefore, primary human endothelial cells and the human endothelial cell lines, HPMEC-ST1.6R and ISO-HAS-1, were examined for adherence and growth patterns on the fibroin nets by confocal laser scanning microscopy after vital staining of the cells and by electron microscopy. Endothelial cells adhered and spread along individual fibers of the nets and did not fill the gaps bet…

Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes.

2004

Abstract Open-cell hollow fibers made of polyethersulfone (PES) manufactured in the absence of solvents with pore diameters smaller than 100 μm were examined for vascularization by human endothelial cells. The goal of this study was to determine whether the 3-D porous character of the PES surface affected human endothelial cell morphology and functions. Freshly isolated human endothelial cells from the skin (HDMEC), from the lung (HPMEC) and from umbilical cords (HUVEC) and two human endothelial cell lines, HPMEC-ST1.6R and ISO-HAS.c1 were added to PES fibers and cell adherence and growth was followed by confocal laser scanning microscopy. Prior coating of PES with gelatin or fibronectin wa…

Upconversion Nanoparticles for Bioimaging and Regenerative Medicine.

2016

Nanomaterials are proving useful for regenerative medicine in combination with stem cell therapy. Nanoparticles can be administrated and targeted to desired tissues or organs and subsequently, be used in non-invasive real-time visualization and tracking of cells by means of different imaging techniques, they can act as therapeutic agent nanocarriers, and can also serve as scaffolds to guide the growth of new tissue. Nanoparticles can be of different chemical nature, such as gold, iron oxide, cadmium selenide, and carbon, and have the potential to be used in regenerative medicine. However, there are still many issues to be solved, such as toxicity, stability, and resident time. Upconversion …

Baltic Journal of Psychology; Volume 15, Number 1-2 

2014

A fuzzy-logic based evolutionary multiobjective approach for automated distribution networks management

2004

In this paper, a methodology to treat constrained scheduling problems based on the repeated application of a fuzzy-logic-based multiobjective algorithm is presented. The application domain is that of automated distribution systems management. In particular, the problem of voltage regulation and power loses minimization is here considered. The classical formulation of the problem of optimal control of shunt capacitor banks and under load tap changers, ULTC, located at high voltage/medium voltage (HV/MV) substations has been coupled with the optimal control of tie-switches and capacitor banks on the feeders of a large radially operated meshed distribution system with the aim of attaining mini…

Voltage Regulation and Power Losses Minimization in Automated Distribution Networks by an Evolutionary Multiobjective Approach

2004

In this paper, the problem of voltage regulation and power losses minimization for automated distribution systems is dealt with. The classical formulation of the problem of optimal control of shunt capacitor banks and Under Load Tap Changers located at HV/MV substations has been coupled with the optimal control of tie-switches and capacitor banks on the feeders of a large radially operated meshed distribution system with the aim of attaining minimum power losses and the flattening of the voltage profile. The considered formulation requires the optimization of two different objectives; therefore the use of adequate multiobjective heuristic optimization methods is needed. The heuristic strate…

Driven Primary Regulation for Minimum Power Losses Operation in Islanded Microgrids

2018

The paper proposes an improved primary regulation method for inverter-interfaced generating units in islanded microgrids. The considered approach employs an off-line minimum losses optimal power flow (OPF) to devise the primary frequency regulation curve’s set-points while satisfying the power balance, frequency and current constraints. In this way, generators will reach an optimized operating point corresponding to a given and unique power flow distribution presenting the minimum power losses. The proposed approach can be particularly interesting for diesel-based islanded microgrids that face, constantly, the issue of reducing their dependency from fossil fuels and of enhancing their gener…

Genomic run-on evaluates transcription rates for all yeast genes and identifies gene regulatory mechanisms

2004

Most studies of eukaryotic gene regulation have been done looking at mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing factors: transcription rate (TR) and mRNA degradation. Both can be important points to regulate gene expression. Here we show a new method that combines the use of nylon macroarrays and in vivo radioactive labeling of nascent RNA to quantify TRs, mRNA levels, and mRNA stabilities for all the S. cerevisiae genes. We found that during the shift from glucose to galactose, most genes undergo drastic changes in TR and mRNA stability. However, changes in mRNA levels are less pronounced. Some genes, such as those encoding mitochondrial pro…