Search results for " Regulation"
showing 10 items of 3187 documents
Effects of different lower-limb sensory stimulation strategies on postural regulation : A systematic review and meta-analysis
2017
Systematic reviews of balance control have tended to only focus on the effects of single lower-limb stimulation strategies, and a current limitation is the lack of comparison between different relevant stimulation strategies. The aim of this systematic review and meta-analysis was to examine evidence of effects of different lower-limb sensory stimulation strategies on postural regulation and stability. Moderate- to high- pooled effect sizes (Unbiased (Hedges’ g) standardized mean differences (SMD) = 0.31–0.66) were observed with the addition of noise in a Stochastic Resonance Stimulation Strategy (SRSS), in three populations (i.e., healthy young adults, older adults, and individuals with lo…
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configurati…
2020
mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in Saccharomyces cerevisiae. We found significant effects of Xrn1 perturbation on RNA pol II profiles across the genome. RNA pol II profiles at 5ʹ exhibited significant alterations that were com…
Affect regulation, mental health disorders, and maladaptive brain responses in music listening : a correlational study
2014
Affect regulation may be defined as a process by which an individual maintains or modifies his or her mood or emotional state, by conscious or automatic processes. Adequate affect regulation may play an important role in mitigating or preventing mental illness, which is a widespread, inadequately treated and inadequately understood phenomenon. Music, which is known to express and induce emotions, may be used for affect regulation in a variety of ways, both self-directed and in therapeutic contexts. The effectiveness, however, of different uses of music in affect regulation is not yet understood. Both psychological testing and neuro-imaging were used to explore the relationship between indiv…
Implicit regulation for automotive variators
2001
A well-known practice uses mechanical variators to realize the so-called continuously variable transmissions (CVTs) for automotive application. A remarkable problem for one of the most used CVTs is given by the hydraulic control of the axial thrust on the half-pulleys that is necessary for torque transmission. It involves a heavy decrease in transmission efficiency. In the present paper, the possible production of the required axial thrust by a simple spring to eliminate hydraulic losses is analysed. It is shown that the power capacity of such a regulated variator is near to the maximum possible, and the belt torque loss is always considerably lower than the sum of the belt and pump losses…
Emisores políticos, mediáticos y ciudadanos en internet: hacia un nuevo marco comunicativo en la jornada de reflexión en España
2015
Resumen La campaña electoral en España está regulada por la ley orgánica de régimen electoral general 5/1985, que no contempla ninguna medida específica para la cibercampaña. Este vacío legal motiva a los emisores a realizar una interpretación de la norma cuando se comunican en internet durante este periodo. Con el fin de explorar si el nuevo tempo y forma de comunicación en internet se corresponde con un nuevo espacio comunicativo, este estudio analiza los mensajes que políticos, periodistas y ciudadanos se intercambiaron en la jornada de reflexión de las últimas elecciones generales españolas (2011) y muestra cómo esta jornada, comprendida hasta la fecha como un día de reflexión silencios…
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
2001
Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 ( a d isintegrin a nd m etalloprotease) as a major target of the cholesterol effects on APP metabolism. Treatment of various peripheral and neural cell lines with either the cholesterol-extracting agent methyl-β-cyclodextrin or the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin resulted in a drastic increase of secreted α-secretase cleaved soluble APP. This strong stimulatory effect was in the range obtained with phorbol esters and was further increa…
It's worth the trouble: Stressor exposure is related to increased cognitive reappraisal ability
2021
Recent theories propose moderate (compared to high or no) stressor exposure to promote emotion regulation capacities. More precisely, stressful situations are expected to serve as practice opportunities for cognitive reappraisal (CR), that is, the reinterpretation of a situation to alter its emotional impact. Accordingly, in this study, we expect an inverted U-shaped relationship between exposure to daily hassles and performance in a CR task, that is, best reappraisal ability in individuals with a history of moderate stressor exposure. Participants (N = 165) reported the number of daily hassles during the last week as indicator of stressor exposure and completed the Script-based Reappraisal…
The Spanish Version of the Empathy Questionnaire (EmQue): Evidence for Longitudinal Measurement Invariance and Relationship With Emotional Regulation
2018
Research Findings: Empathy, or the ability to understand what others are thinking or feeling, can be observed in early developmental stages. The purpose of this study was to validate the Spanish ve...
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors
2020
[Image: see text] Breast cancer (BC) is the most diffused cancer type in women and the second leading cause of death among the female population. Effective strategies to fight estrogen responsive (ER+) BC, which represents 70% of all BC cases, rely on estrogen deprivation, via the inhibition of the aromatase enzyme, or the modulation of its cognate estrogen receptor. Current clinical therapies significantly increased patient survival time. Nevertheless, the onset of resistance in metastatic BC patients undergoing prolonged treatments is becoming a current clinical challenge, urgently demanding to devise innovative strategies. In this context, here we designed, synthesized, and performed in …
Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps
2013
Background A number of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) are resistant to oral corticosteroids. Mucin 1 (MUC1) shows anti-inflammatory properties, and its cytoplasmic tail (CT) interacts with transcription factors, facilitating their nuclear translocation. Because glucocorticoid receptor (GR) nuclear translocation is key to the anti-inflammatory effect of corticosteroids, we hypothesized that MUC1 is involved in the effectiveness of corticosteroids. Objective To analyze the role of MUC1 in corticosteroid effectiveness in different cohorts of patients with CRSwNP and elucidate the possible mechanisms involved. Methods Seventy-three patients with CRSwNP took oral…